Tag: M.W=150-200

Alexeev, Vladimir L. published the artcilePhotonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid, Name: (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, the publication is Clinical Chemistry (Washington, DC, United States) (2004), 50(12), 2353-2360, database is CAplus and MEDLINE.

Background: We recently developed a photonic crystal glucose-sensing material, which consists of a crystalline colloidal array embedded within a polymer network of a polyacrylamide-poly(ethylene glycol) hydrogel with pendent phenylboronic acid groups. The aim of the present work was to improve this approach for application to noninvasive or minimally invasive monitoring of glucose. Methods: We used new boronic acid derivatives such as 4-amino-3-fluorophenylboronic acid and 4-carboxy-3-fluorophenylboronic acid as the mol. recognition elements to achieve sensing at physiol. pH values. Results: The improved photonic glucose-sensing material sensed glucose in the range of the 100 μmol/L concentrations found in tear fluid. The detection limits were ∼1 μmol/L in synthetic tear fluid. The visually evident diffraction color shifted across the entire visible spectral region from red to blue over the physiol. relevant tear-fluid glucose concentrations This sensing material is selective for glucose over galactose, mannose, and fructose. Conclusions: These new glucose sensors have properties appropriate for use in such glucose-sensing applications as ocular inserts or diagnostic contact lenses for patients with diabetes mellitus.

Clinical Chemistry (Washington, DC, United States) published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Name: (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Delehanty, James B. published the artcileSynthesis of a reactive oxygen species-responsive doxorubicin derivative, COA of Formula: C4H6F3NOS, the publication is Molecules (2018), 23(7), 1809/1-1809/5, database is CAplus and MEDLINE.

A heterobifunctional reactive oxygen species (ROS)-responsive linker for directed drug assembly onto and delivery from a quantum dot (QD) nanoparticle carrier was synthesized and coupled to doxorubicin using N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC)/sulfo-NHS coupling. The doxorubicin conjugate was characterized using 1H NMR and LC-MS and subsequently reacted under conditions of ROS formation (Cu2+/H2O2) resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using 1H NMR.

Molecules published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, COA of Formula: C4H6F3NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wu, Danchen published the artcileIdentification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury, Computed Properties of 530-40-5, the publication is FASEB Journal (2020), 34(1), 1447-1464, database is CAplus and MEDLINE.

Mitochondrial fission is important in physiol. processes, including coordination of mitochondrial and nuclear division during mitosis, and pathol. processes, such as the production of reactive oxygen species (ROS) during cardiac ischemia-reperfusion injury (IR). Mitochondrial fission is mainly mediated by dynamin-related protein 1 (Drp1), a large GTPase. The GTPase activity of Drp1 is essential for its fissogenic activity. Therefore, we aimed to identify Drp1 inhibitors and evaluate their anti-neoplastic and cardioprotective properties in five cancer cell lines (A549, SK-MES-1, SK-LU-1, SW 900, and MCF7) and an exptl. cardiac IR injury model. Virtual screening of a chem. library revealed 17 compounds with high predicted affinity to the GTPase domain of Drp1. In silico screening identified an ellipticine compound, Drpitor1, as a putative, potent Drp1 inhibitor. We also synthesized a congener of Drpitor1 to remove the methoxymethyl group and reduce hydrolytic lability (Drpitor1a). Drpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Drpitor1 and Drpitor1a have greater potency than the current standard Drp1 GTPase inhibitor, mdivi-1, (IC50 for mitochondrial fragmentation are 0.09, 0.06, and 10μM, resp.). Both Drpitors reduced proliferation and induced apoptosis in cancer cells. Drpitor1a suppressed lung cancer tumor growth in a mouse xenograft model. Drpitor1a also inhibited mitochondrial ROS production, prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury. In conclusion, Drpitors are useful tools for understanding mitochondrial dynamics and have therapeutic potential in treating cancer and cardiac IR injury.

FASEB Journal published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H15ClO3S, Computed Properties of 530-40-5.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ough, Cornelius S. published the artcileIdentification of new volatile amines in grapes and wines, Quality Control of 360-92-9, the publication is Journal of Agricultural and Food Chemistry (1981), 29(5), 938-41, database is CAplus and MEDLINE.

A number of amines were identified for the 1st time in grapes. These include MeNH₂ [74-89-5], EtNH₂ [75-04-7], Et₂NH [109-89-7], PrNH₂ [107-10-8], isobutylamine [78-81-9], α-amylamine [96-15-1], isoamylamine [107-85-7], pyrrolidine [123-75-1], and 2-phenethylamine [64-04-0]. The trifluoroacetamides of the isolated amines were separated on Carbowax 20M or SE54 fused silica capillary columns and identified by retention times and mass spectra. Two amines, di-Et and α-amyl, were identified in wine for the 1st time. Mass spectra of the pure trifluoroacetyl derivatives of these amines are given. In a recent review, P. Schreier (1979) compiled a list of the volatile amines found in wines. The volatile amines he summarized plus others detected in wines are given.

Journal of Agricultural and Food Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bastos, Gustavo A. published the artcileA convenient Hofmann reaction of carboxamides and cyclic imides mediated by trihaloisocyanuric acids, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2021), 153422, database is CAplus.

A simple, efficient and pot-economic approach in a single vessel has been developed for conversion of aromatic and aliphatic carboxamides into primary amines with one fewer carbom atom (Hofmann reaction) in 38-89% yield by reacting with trichloro- or tribromoisocyanuric acid and sodium hydroxide in aqueous acetonitrile. Under the same reaction conditions, cyclic imides gave amino acids (69-83%). The role of the trihaloisocyanuric acids is the in situ generation of N-haloamides, key-intermediates for the Hofmann reaction. The scalability of the methodol. was demonstrated by a multigram-scale transformation of phthalimide into anthranilic acid in 77% yield.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Blencowe, Anton published the artcileSurface modification of nylon 6,6 using a carbene insertion approach, Name: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is New Journal of Chemistry (2006), 30(1), 53-58, database is CAplus.

The diazirine functionalized fluorenone, 3-[3-(trifluoromethyl)diazirin-3-yl]phenyl-9-oxo-9H-fluorene-2-carboxylate was synthesized to act as a model compound capable of modifying a wide variety of polymeric substrates. Photochem. activation of the diazirine moiety of the fluorenone derivative was utilized to afford highly reactive carbenes capable of insertion into or addition to a wide variety of functionalities. The photoinduced attachment of a fluorenone derivative to nylon 6,6 has been studied using UV-visible spectroscopic anal. Incorporation of the fluorenone chromophore onto the backbone of nylon at different loading levels and after different coating cycles has been investigated and is detailed.

New Journal of Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Name: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Karp, Gary M. published the artcile3-(Heterocyclyl)phenyl cyanurates: synthesis and herbicidal activity, Synthetic Route of 2447-79-2, the publication is ACS Symposium Series (2002), 30-40, database is CAplus.

3-(Heterocyclyl)phenyl cyanurates such as I make up a novel class of protoporphyrinogen oxidase (protox) inhibitors which were prepared and evaluated for herbicidal activity. The compounds were primarily postemergence broadleaf compounds The effect of changes in the aryl moiety, the heteroaryl moiety, and in the pendant ester of the cyanurate moiety on the herbicidal activity of the heterocyclylaryl cyanurates was studied.

ACS Symposium Series published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kummer, David A. published the artcileIdentification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt, Application of N-Methoxy-N-methylisonicotinamide, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(9), 2047-2057, database is CAplus and MEDLINE.

A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alc. hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Application of N-Methoxy-N-methylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chen, Chen published the artcileA Convenient Synthetic Method for Trisubstituted s-Triazines, Name: 2,4-Dichlorobenzamide, the publication is Journal of Organic Chemistry (1995), 60(26), 8428-30, database is CAplus.

S-Triazines bearing a variety of substituents at the 1, 3 and 5-positions are obtained in good yields by the condensation of N’-acyl-N,N-dimethylamidines with amidines or guanidines . The N’-acyl-N,N-dimethylamidines are readily prepared from amides and N,N-dimethylformamide di-Me acetal or N,N-dimethylacetamide di-Me acetal .

Journal of Organic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chen, Xingmei published the artcileMachine learning-based prediction of toxicity of organic compounds towards fathead minnow, Application In Synthesis of 2447-79-2, the publication is RSC Advances (2020), 10(59), 36174-36180, database is CAplus and MEDLINE.

Predicting the acute toxicity of a large dataset of diverse chems. against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approx. ratio of 1 : 1. Only six mol. descriptors were used to establish the quant. structure-activity/toxicity relationship (QSAR/QSTR) model for 96 h pLC₅₀ through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R² = 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (q_int² = 0.699 and q_ext² = 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six mol. descriptors and a large data set for the test set consisting of 481 compounds

RSC Advances published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics