Tag: M.W=150-200

Cash, Gordon G. published the artcilePrediction of inhibitory potencies of arenesulfonamides toward carbonic anhydrase using easily calculated molecular connectivity indices, Safety of 3-Acetylbenzenesulfonamide, the main research area is carbonic anhydrase inhibitor arenesulfonamide QSAR.

Previous literature reports described the correlation of arenesulfonamide inhibitory potency toward carbonic anhydrase with a quantum mech. descriptor, namely, the total charge on the sulfonamide oxygens, and an indicator variable. The present paper attempts to correlate the same inhibitory potency data with the much more easily calculated mol. connectivity indexes (MCIs) for the same set of compounds A good (r = 0.91) two-variable correlation was found for an subset, from which compounds with a certain structural characteristic had been excluded. This result is consistent with many previous reports that MCIs do well in predicting relative biol. activities of a homologous series of compounds but less well for groups of compounds that differ at several sites.

Structural Chemistry published new progress about QSAR (quantitative structure-activity relationship). 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Safety of 3-Acetylbenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ingemann, M. published the artcileStability of enzymes formulated for oral drug delivery, Product Details of C10H16N2O2, the main research area is oral drug delivery enzyme stability.

An oral drug delivery system based on entrapment of an enzyme of interest in acrylic hydrogel is, from a stability point of view, possible for lipase but not for phenylalanine ammonia lyase (PAL). Loss in enzymic activity, when monomers were present, may be caused by conformational changes in the PAL mol. as indicated in CD and fluorescence anal. It was shown that the proteolytic stability of free enzymes has to be improved by the aid of a drug delivery system before oral enzyme substitution therapy by PAL is possible.

Proceedings of the International Symposium on Controlled Release of Bioactive Materials published new progress about Oral drug delivery systems. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Product Details of C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Baek, Kyung-Youl published the artcileCore-Functionalized Star Polymers by Transition Metal-Catalyzed Living Radical Polymerization. 1. Synthesis and Characterization of Star Polymers with PMMA Arms and Amide Cores, SDS of cas: 10405-38-6, the main research area is star PMMA preparation functionalized divinyl core; microgel divinyl core PMMA star; amide microgel core PMMA star.

A series of microgel core-functionalized star-shaped polymers was synthesized by the polymer linking reaction method in RuCl2(PPh3)3-catalyzed living radical polymerization The synthesis was achieved by the polymer linking reaction method; i.e., functionalized divinyl compounds were added in situ to the solution of linear living poly(MMA)s prepared with the Ru(II)-catalyzed living radical polymerization The functionalized microgel cores thus obtained contained acrylamide and methacrylamide. Also, star polymers with varying densities of the microgel cores were prepared from diacrylamides with various lengths and structures of the spacer, and by changing the relative amounts of MMA (arm length) and divinyl compound (core size) to initiator, a variety of core-functionalized star polymers could be obtained in high yield. These core-functionalized star-shaped polymers have f of 20-640, Mw of 3.3 × 105-1.3 × 107, and Rz of 5-42 nm. These results indicated that the cores carry as many as 440-51,000 amide groups in microgel networks.

Macromolecules published new progress about Radius of gyration. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, SDS of cas: 10405-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rowan, Andrew S. published the artcilePreparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology, Synthetic Route of 35203-88-4, the main research area is carbonyl reductase chiral alc stereoselective reduction.

Libraries of highly enantioenriched secondary alcs. in both enantiomeric forms were synthesized by enzymic reduction of their parent ketones using selectAZyme carbonyl reductase (CRED) technol. Com. available CREDs were able to reduce a range of substrate classes efficiently and with very high enantioselectivity. Matching substrate classes to small subsets of CREDs enabled the fast development of preparative bioredns. and the rapid generation of 100-1500 mg samples of chiral alcs. in typically >95% ee and the majority in �9.0% ee. The conditions for small scale synthesis were then scaled up to 0.5 kg to deliver one of the chiral alcs., (S)-1-(4-bromophenyl)-2-chloroethanol, in 99.8% ee and 91% isolated yield.

Tetrahedron: Asymmetry published new progress about Enantioselective synthesis. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Synthetic Route of 35203-88-4.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Feng; Lu, Lei; Ma, Juan published the artcile< Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2>, Computed Properties of 5004-88-6, the main research area is quinazolinone preparation green chem; aminobenzamide aldehyde acceptorless dehydrogenative condensation iridium complex catalyst.

A general and efficient method for the synthesis of quinazolinones, e.g., I via acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes in water has been accomplished. In the presence of [Cp*Ir(H2O)3][OTf]2, a variety of desirable products were obtained in high yields with high atom economy under environmentally benign conditions. Notably, this research will facilitate the progress of acceptorless dehydrogenative reactions in water catalyzed by water-soluble organometallic complexes.

Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Guozhi; Kertesz, Denis J.; Yang, Minmin; Lin, Xianfeng; Wang, Zhanguo; Li, Wentao; Qiu, Zongxing; Chen, Junli; Mei, Jianghua; Chen, Li; Mirzadegan, Taraneh; Harris, Seth F.; Villasenor, Armando G.; Fretland, Jennifer; Fitch, William L.; Hang, Julie Qi; Heilek, Gabrielle; Klumpp, Klaus published the artcile< Exploration of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses>, Category: amides-buliding-blocks, the main research area is piperidinylpyrimidinamine preparation HIV 1 reverse transcriptase inhibitor; pyrimidinamine piperidinyl preparation structure activity relationship antiviral.

Further investigation on the recently reported N-(piperidin-4-yl)pyrimidin-2-amines I (R = H, 4-Cl, 5-Cl, 6-Cl; R1 = H, 4-SO2NH2, 3-SO2NH2, 2-CONH2, 3-CONH2, 4-CONH2, 3-SO2Me, 3-CN, 3-CO2H; R2 = H, Br, Cl, F, Me, CF3, NH2, NO2; R3 = Me, Cl, OMe, F) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) was carried out. Thus, preparation of a series of N-phenylpiperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Two of the compounds were very potent vs. wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis (no data), structure-activity relationship (SAR), clearance data, and crystallog. evidence for the binding motif were discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Xue-Mei; Huang, En-Ling; Zhu, Yu-Shen; Li, Jing; Song, Bing; Zhu, Xinju; Hao, Xin-Qi published the artcile< Oxidative sulfonamidomethylation of imidazopyridines utilizing methanol as the main C1 source>, Formula: C6H6FNO2S, the main research area is phenyl imidazopyridine methanol sulfamide oxidative sulfonamidomethylation; imidazopyridine methanol amine oxidative aminomethylation.

An efficient one-pot, three-component synthesis of C3 sulfonamidomethylated imidazopyridines was disclosed under metal-free conditions, which utilized the com. available and renewable reagent methanol as the main methylene source. A wide range of substituted imidazopyridines and sulfamides/amines were well tolerated to afford the corresponding products in up to 92% yield. In the isotopic labeling experiment, it was found that a minor part of the methylene also originated from DTBP. Moreover, the radical scavenger reactions were conducted, which suggested that a free-radical mechanism was probably not involved. The current methodol. featured several advantages, including broad substrate scope, good functional group tolerance and high reaction efficiency.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Formula: C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya published the artcile< Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells>, Computed Properties of 5004-88-6, the main research area is diarylamide urea Tranilast analog preparation vascular cell proliferation.

A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound I was superior to the lead compound, Tranilast, in terms of its potency of inhibitory activity and cell selectivity.

Bioorganic & Medicinal Chemistry published new progress about Cell proliferation. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Yahuan; Wang, Zheng; Zhao, Ziwei; Gao, Pengxiang; Ma, Ning; Liu, Qingbin published the artcile< Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex>, SDS of cas: 6961-82-6, the main research area is aryl alkyl chloride bromide hydrodehalogenation diphosphine ruthenium catalyst.

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides.

Molecular Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Kai; Ke, Miaolin; Lin, Yuanguang; Song, Qiuling published the artcile< Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature>, SDS of cas: 1524-40-9, the main research area is morpholine piperidine pyrrolidine sulfonamide analog preparation; sulfonamide preparation green chem.

A novel, practical and highly efficient method for the construction of a variety of sulfonamides mediated by iodine (I2) was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates (sulfinic acid salts) and amines or ammonia in water in a metal-free, base-free, ligand-free or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of functional group tolerability. The synthesis of the target compounds was achieved using benzenamine derivatives (aryl amines, aromatic amines), benzenemethanamine (benzyl amine, aralkyl amine), 1H-benzimidazole derivatives, 3-pyridinamine, N-ethylethanamine, pyrrolidine, piperidine, morpholine, 2-propyn-1-amine (propargyl amine), diallylamine, N,N’-dimethyl-1,2-ethanediamine, L-leucine Me ester hydrochloride, L-phenylalanine Me ester hydrochloride as starting materials. Sulfinic acid salts included benzenesulfinic acid sodium salt, 8-quinolinesulfinic acid sodium salt, cyclopropanesulfinic acid sodium salt, 2-naphthalenesulfinic acid sodium salt. The title compounds thus formed included benzenesulfonamide derivatives and analogs such as 1-(phenylsulfonyl)piperidine, 1-(phenylsulfonyl)morpholine, 1-(phenylsulfonyl)pyrrolidine, 1-(phenylsulfonyl)-1H-benzimidazole, 4-(2-naphthalenylsulfonyl)morpholine, 8-(4-morpholinylsulfonyl)quinoline. Amino acid derivatives included N-(phenylsulfonyl)-L-leucine Me ester and N-(phenylsulfonyl)-L-phenylalanine Me ester.

Green Chemistry published new progress about Allyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, SDS of cas: 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics