Tag: M.W=150-200

Appel, Rolf; Montenarh, Mathias published the artcile< Addition reaction of N,N-dialkylsulfamides, tertiary amines, and phosphines with fluorosulfonyl isocyanate>, Category: amides-buliding-blocks, the main research area is addition sulfamide fluorosulfonyl isocyanate; amine fluorosulfonyl isocyanate reaction; phosphine fluorosulfonyl isocyanate reaction; urea fluorosulfonyl sulfamoyl.

Addition of RSO2NH2 to FSO2NCO gave 72-98% RSO2NHCONHSO2F (R = Me2N, piperidino, morpholino, MeO), thermal decomposition of which gave 20-48% RSO2F (R = Me2N, piperidino, morpholino). The reaction of FSO2NCO with amines and phosphines gave 91-99% 1:1 adducts RR12E+CON-SO2F (RR12E = Et3N, pyridine, Me3P, PhEt2P, MePh2P, Ph3P).

Chemische Berichte published new progress about Addition reaction. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogawa, Nobuo; Yoshida, Toshihiko; Aratani, Takayuki; Koshinaka, Eiichi; Kato, Hideo; Ito, Yasuo published the artcile< Synthesis and histamine H2-antagonist activity of 4-quinazolinone derivatives>, Quality Control of 5004-88-6, the main research area is piperidinylmethylphenoxypropylaminoquinazolinone preparation antiulcer histamine antagonist; quinazolinone piperidinylmethylphenoxypropylamino preparation histamine antagonist; structure activity aminomethylphenoxyalkylaminoquinazolinone histamine antagonist.

With the aim of developing new antiulcer agents, a series of 4-quinazolinone derivatives e.g., I (R = piperidino, pyrrolidino, morpholino, R1 = H, OMe, R2 = H, Me; n = 2, 3, 4) was synthesized and tested for histamine H2-antagonist activity and gastric antisecretory activity. Thus, 2-alkylamino-, 2-alkylthio-, and 2-alkyl-4-quinazolinones were prepared by the condensation of alkylamines with 2-chloro- or 2-methylthio-4-quinazolinones, the condensation of alkyl bromides with 2-mercapto-4-quinazolinones, and the condensation of alkylcarboxylic acids with anthranilamides, resp. Several of the 4-quinazolinone derivatives showed potent H2-antagonist activity, and one of them, I (R = piperidino, R1 = R2 = H, n = 3), showed the most potent antisecretory activity. The structure-activity relationships are discussed.

Chemical & Pharmaceutical Bulletin published new progress about Histamine H2 receptor antagonists. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Quality Control of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe published the artcile< 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action>, Formula: C9H12N2O3, the main research area is cinnamamido phenylpropiolamido phenylpropanamidobenzamide preparation anticancer; 2-(3-Phenylpropanamido)benzamides; 2-(3-Phenylpropiolamido)benzamides; 2-Cinnamamidobenzamides; Antiproliferative activity; Apoptosis; DYCGFIFOMKVDQP-UHFFFAOYSA-N; GAEWJVNXMYWFOT-FPYGCLRLSA-N; GLOIPBXNPXFMCD-CMDGGOBGSA-N; GTMVKWANDDSBPP-UHFFFAOYSA-N; GUWKFLZAMNTMFA-UHFFFAOYSA-N; IBBGALVVPWZGNP-JXMROGBWSA-N; IRYCZCAWVJZWKT-QPJJXVBHSA-N; JZURWIGFELHAQF-UHFFFAOYSA-N; LIWFXFAWCAUFBU-UHFFFAOYSA-N; LRIOFNWWMBLPSV-RMKNXTFCSA-N; MTEXNJMFEMIDJZ-CSKARUKUSA-N; MVXMFTXNNUIRAF-UHFFFAOYSA-N; MWHVYZNXRYFKFD-UHFFFAOYSA-N; OEHLQIRCXNADOK-JXMROGBWSA-N; PIQFLKOEQNXADK-QPJJXVBHSA-N; QUNOMTLXTSUWOB-CMDGGOBGSA-N; RHBJSXACCJTPRE-UHFFFAOYSA-N; USJUKEPNAZAKSG-UHFFFAOYSA-N; WMHHXKMPUMTPIJ-RMKNXTFCSA-N; WPPDXKZWCFUROB-UHFFFAOYSA-N; XMXNTDIXMAUMEJ-UHFFFAOYSA-N; ZLNSPXKNAWBJIG-ZHACJKMWSA-N; ZXBUZBGNIFHLGX-UHFFFAOYSA-N.

Several new benzamides were synthesized by stirring in pyridine the acid chlorides with the appropriate anthranilamide derivatives Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

European Journal of Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Feng; Lu, Lei; Liu, Pengcheng published the artcile< Acceptorless Dehydrogenative Coupling of o-Aminobenzamides with the Activation of Methanol as a C1 Source for the Construction of Quinazolinones>, HPLC of Formula: 5004-88-6, the main research area is dehydrogenative coupling aminobenzamide methanol iridium catalyst; quinazolinone preparation dehydrogenative coupling aminobenzamide methanol iridium catalyst.

A strategy for the synthesis of quinazolinones I (R = H, 7-Me, 6-MeO, 8-F, etc.) via acceptorless coupling of o-aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)]. Notably, this research exhibited the potential of transition-metal-catalyzed activation of methanol as a C1 source for the construction of heterocycles.

Organic Letters published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (o-aminobenzamides). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, HPLC of Formula: 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vu, Huu-Manh; Yong, Jia-Yuan; Chen, Fei-Wu; Li, Xu-Qin; Shi, Guo-Qing published the artcile< Rhodium-Catalyzed C(sp2)-H Amidation of Azine with Sulfonamides>, Quality Control of 6961-82-6, the main research area is regioselective rhodium catalyzed amidation azine sulfonamide.

Direct C-H amidation of azine with sulfonamide was developed for the first time. The reactions proceeded smoothly under benign conditions and gave the corresponding products with high selectivity. This approach shows high regioselectivity, wide substrate scope, and functional group tolerance. Addnl., this transformation can also be scaled up to the gram level. This strategy allows for the direct preparation of ortho-sulfonamide-substituted ketone products, thus providing a good complement to previous C-H amidation.

Journal of Organic Chemistry published new progress about Amidation. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Kui; Li, Yajun published the artcile< Solid-liquid phase equilibrium and solution thermodynamics of 2-chlorobenzenesulfonamide in 16 mono solvents at temperature ranging from 273.15 K to 324.65 K>, Application In Synthesis of 6961-82-6, the main research area is chlorobenzenesulfonamide solid liquid phase equilibrium solution thermodn.

The synthesis and separation processes of chem. intermediate is based on the knowledge of its solid-liquid phase equilibrium with solvents in industry. In this work, the solubility of 2-chlorobenzenesulfonamide in 16 single pure solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, 2-butanone, 2-pentanone, cyclohexanone, cyclopentanone, Et acetate, Me acetate, Et formate, acetonitrile and THF was determined at temperature range from 273.15 to 324.65 K and atm. pressure. The mole fraction solubility of 2-chlorobenzenesulfonamide in all selected mono solvents was enhanced by an increase in temperature In addition, the exptl. data were further correlated by the modified Apelblat equation, λh equation, NRTL model and Wilson model. The values of RAD with NRTL equation were smaller than those with other three models, and thus the NRTL model offered the best fitting performance. The thermodn. functions of dissolution including enthalpy, entropy, and Gibbs energy were derived, and the results expectedly suggested a spontaneous and entropy-driven mixing process. All the crystallog. and thermodn. data reported in this study provides the fundamental data for designing and optimizing of the reaction and crystallization processes of 2-chlorobenzenesulfonamide.

Journal of Molecular Liquids published new progress about Crystallization. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jia, Yibo; Li, Lin; Duan, Lili; Li, Yue-Ming published the artcile< The aza-Prins Cyclization of Unfunctionalized Olefins Promoted by NHC-Cu Complex and ZrCl4>, Related Products of 6961-82-6, the main research area is piperidine preparation diastereoselective zirconium tetrachloride NHC copper catalyst; homoallylic amine aldehyde aza Prins cyclization.

The aza-Prins cyclization reaction catalyzed by ZrCl4 and NHC (N-heterocyclic carbene) metal complexes is firstly reported. NHC-copper complexes as promoter and ZrCl4 as chloride source are utilized under a mild condition, where homoallylic amines and aldehydes are successfully converted to piperidine derivatives in satisfactory yields and diastereoselectivity.

Applied Organometallic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Ying; Sarris, Kathy; Sauer, Daryl R.; Djuric, Stevan W. published the artcile< An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents>, Application of C6H6FNO2S, the main research area is acylsulfonamide preparation; acylation sulfonamide carboxylic acid polymer supported reagent.

Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the com. available reagents, PS-DCC and DMAP under mild reaction conditions. DMAP can be efficiently scavenged by utilization of a silica-supported tosic acid cartridge (Si-SCX). In most of the cases studied, products with high purities and yields were obtained without the need for further purification

Tetrahedron Letters published new progress about Acylation. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Application of C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guerra, Walter D.; Lucena-Agell, Daniel; Hortigueela, Rafael; Rossi, Roberto A.; Fernando Diaz, J.; Padron, Jose M.; Barolo, Silvia M. published the artcile< Design, Synthesis, and in vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block>, Application In Synthesis of 6961-82-6, the main research area is dibenzothiazine preparation antiproliferative SAR cell cycle tubulin inhibitor human; Antiproliferation; dibenzothiazines; drug design; sulfonamides; tubulin inhibitors.

A series of free NH and N-substituted dibenzonthiazines I [R1 = H, F, CF3, Ph; R2 = H, 9-F, 7-Ph, etc.; R3 = H, Me, Bn, etc.] with potential anti-tumor activity from N-aryl-benzenesulfonamides was prepared A biol. test of synthesized compounds was performed in vitro measuring their antiproliferative activity against a panel of six human solid tumor cell lines and its tubulin inhibitory activity. Compounds I [R1 = R2 = H; R3 = SO2C6H5, 4-MeC6H4SO2] showed as the best compounds with promising values of activity (overall range of 2-5.4μM).

ChemMedChem published new progress about Antiproliferative agents. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dong, Pei; Li, Zhaojing; Liu, Xiaohua; Dong, Shunxi; Feng, Xiaoming published the artcile< Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines>, Application of C6H6ClNO2S, the main research area is isocyanoethyl indole aziridine dysprosium catalyst enantioselective tandem reaction; phenyltetrahydropyrrolo pyridoindole dicarboxylate preparation.

Herein, a tailored strategy to access such compounds through an asym. ring-opening/Friedel-Crafts/Mannich/desulfonylation cascade reaction was reported. In the presence of the N,N’-dioxide-Dy(III) complex, various 2,2′-diester aziridines and 3-(2-isocyanoethyl)indoles were converted into tetracyclic spiroindolines in a highly diastereo- and enantioselective manner (41 examples, up to 88% yield, 97% ee). On the basis of the absolute configuration of the product and previous works, a possible catalytic cycle was proposed to understand the origin of stereocontrol.

Organic Chemistry Frontiers published new progress about Aziridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics