Tag: M.W=150-200

Howard, Kaitlind C.; Gonzalez, Octavio A.; Garneau-Tsodikova, Sylvie published the artcile< Second Generation of Zafirlukast Derivatives with Improved Activity against the Oral Pathogen Porphyromonas gingivalis>, Electric Literature of 1524-40-9, the main research area is zafirlukast derivative synthesis antibacterial cytotoxicity Porphyromonas gingivalis periodontal disease.

Porphyromonas gingivalis is a Gram-neg. anaerobic pathogen that can trigger oral dysbiosis as an early event in the pathogenesis of periodontal disease. The FDA-approved drug zafirlukast (ZAF) was recently shown to display antibacterial activity against P. gingivalis. Here, 15 novel ZAF derivatives were synthesized and evaluated for their antibacterial activity against P. gingivalis and for their cytotoxic effects. Most derivatives displayed superior antibacterial activity against P. gingivalis compared to ZAF and its first generation derivatives along with little to no growth inhibition of other oral bacterial species. The most active compounds displayed bactericidal activity against P. gingivalis and less cytotoxicity than ZAF. The superior and selective antibacterial activity of ZAF derivatives against P. gingivalis along with an increased safety profile compared to ZAF suggest these new compounds, especially 14b and 14e, show promise as antibacterials for future studies aimed to test their potential for preventing/treating P. gingivalis-induced periodontal disease.

ACS Medicinal Chemistry Letters published new progress about Antibacterial agents. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Electric Literature of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Feng, Jian-Bo; Wu, Xiao-Feng published the artcile< A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia>, Computed Properties of 1524-40-9, the main research area is sulfonamide primary aryl preparation green chem; thiol aryl ammonia oxidation iodine catalyst.

A general and efficient methodol. for preparing a wide range of primary sulfonamides, RSO2NH2 (R = 3,4-dichlorophenyl, naphthalen-2-yl, 1H-1,3-benzodiazol-2-yl, etc.) from the corresponding thiols RSH and aqueous ammonia, by using iodine as the catalyst and TBHP (70% in water) as the oxidant, in moderate to good yields has been developed.

Organic & Biomolecular Chemistry published new progress about Arenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Computed Properties of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fu, Shaomin; Yang, Honghao; Li, Guoqiang; Deng, Yuanfu; Jiang, Huanfeng; Zeng, Wei published the artcile< Copper(II)-Catalyzed Enantioselective Intramolecular Cyclization of N-Alkenylureas>, Quality Control of 1524-40-9, the main research area is copper catalyzed enantioselective intramol cyclization alkenylurea bicyclic heterocycle synthesis; vicinal diamine cyclic enantioselective synthesis.

The first Cu(II)-catalyzed highly enantioselective intramol. cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles [e.g., I → II (73%, 90% ee)]. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkenylureas). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Quality Control of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dong, Wei; Ge, Zemei; Wang, Xin; Li, Ridong; Li, Runtao published the artcile< Cu-mediated one-pot three-component synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives>, Quality Control of 6961-82-6, the main research area is halobenzenesulfonamide amine carbon disulfide copper catalyst three component reaction; amino benzodithiazine dioxide preparation.

A novel and efficient copper-catalyzed one-pot procedure for the synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives from 2-halobenzenesulfonamides, amines and CS2 was described. The reaction proceeded through Ullmann-type S-arylation, intramol. addition of NH2 with C=S and dehydrosulfide, which provided a new and useful strategy for construction of cyclic aromatic sulfonamides.

Tetrahedron published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Quality Control of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheloufi, H.; Belhani, B.; Ouk, T. S.; Zerrouki, R.; Aouf, N.-E.; Berredjem, M. published the artcile< Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard>, Product Details of C4H10N2O3S, the main research area is sulfonylcyclourea derive nitrogen mustard; Antitumor; Cancer; Nitrogen mustard; Sulfonamides; Sulfonylcycloureas.

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a-m) with Et bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Molecular Diversity published new progress about Antitumor agents. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Product Details of C4H10N2O3S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xia, Y.; Yang, Z.-Y.; Hour, M.-J.; Kuo, S.-C.; Xia, P.; Bastow, K. F.; Nakanishi, Y.; Nampoothiri, P.; Hackl, T.; Hamel, E.; Lee, K.-H. published the artcile< Antitumor Agents. Part 204:1 Synthesis and Biological Evaluation of Substituted 2-Aryl Quinazolinones>, Synthetic Route of 5004-88-6, the main research area is quinazolinone aryl preparation antitumor HIV agent; tubulin polymerization inhibitor arylquinazolinone preparation.

A series of 2-aryl-quinazolinones I (R6 = R7 = H, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = H, R4′ = F; R6 = R7 = OMe, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = H, R4′ = F; R6 = R7 = H, OMe, R2′ = H, R3’R4′ = CH:CHCH:CH; R6 = R7 = H, R2′ = H, R3′ = OMe, R4′ = H; R6 = OMe, R7 = H, R2′ = H, R3′ = OMe, R4′ = H; R6 = R7 = OMe, R2′ = H, R3′ = OMe, R4′ = H) was synthesized and evaluated for biol. activity. Among them, I (R6 = OMe, R7 = H, R2′ = H, R3′ = OMe) displayed significant growth inhibitory action against a panel of tumor cell lines and was also a potent inhibitor of tubulin polymerization Quinazolinones I (R6 = R7 = H, R2′ = F, R3′ = H, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = F, R4′ = H; R6 = R7 = H, R2′ = H, R3′ = H, R4′ = F) displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx. Anti-HIV activity of some of the prepared quinazolinones in acutely infected H9 lymphocytes was also assayed.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-HIV agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Tao; Hua, Jiawei; Bian, Mixue; Qin, Hong; Lin, Xinxin; Yang, Xiaobing; Liu, Chengkou; Yang, Zhao; Fang, Zheng; Guo, Kai published the artcile< Visible light-promoted aerobic oxidative cleavage and cyclization of olefins to access 3-hydroxy-isoindolinones>, Related Products of 6961-82-6, the main research area is alkenylbenzamide iron catalyst photochem regioselective aerobic oxidative cleavage heterocyclization; hydroxy isoindolinone preparation green chem.

A convenient and environmentally friendly synthetic route from 2-vinylbenzimides to 3-hydroxy-isoindolinones through visible light-promoted transformations via iron/disulfide catalysis and mol. oxygen oxidation was developed. A range of 3-hydroxy-isoindolinones were obtained in moderate to good yields, which exhibited excellent functional group compatibility and broad substrate scope. Further mechanistic investigations proved that dioxetane might be a key intermediate being involved in the reaction.

Organic Chemistry Frontiers published new progress about Amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Weikang; Meng, Chong; Liu, Yan; Tang, Yawen; Li, Feng published the artcile< Auto-Tandem Catalysis with Ruthenium: From o-Aminobenzamides and Allylic Alcohols to Quinazolinones via Redox Isomerization/Acceptorless Dehydrogenation>, COA of Formula: C9H12N2O3, the main research area is quinazolinone preparation; aminobenzamide alc tandem redox isomerization dehydrogenation ruthenium catalyst microwave.

A strategy for the synthesis of quinazolinones I [R = H, 7-Me, 6,8-di-Cl, etc.; R1 = Et, i-Pr, n-Bu, etc.; R2 = H, n-Bu, Bn] was proposed via Ru-catalyzed redox isomerization/acceptorless dehydrogenation of o-aminobenzamides with allylic alcs. and was obtained in moderate to high yields. This strategy was attractive due to high atom efficiency, minimal consumption of chems. and energy.

Advanced Synthesis & Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, COA of Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Belhani, Billel; Berredjem, Malika; Le Borgne, Marc; Bouaziz, Zouhair; Lebreton, Jacques; Aouf, Nour-Eddine published the artcile< A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions>, Safety of Morpholine-4-sulfonamide, the main research area is alpha sulfamidophosphonate preparation green chem; benzaldehyde sulfamide trialkylphosphite sonication three component reaction.

An efficient and convenient one-pot synthesis of novel α-sulfamidophosphonates was described via a three-component reaction. This reaction was carried out through a three component condensation reaction of sulfamide, an aromatic aldehyde and trialkylphosphite under conventional/ultrasonic techniques, catalyst-free and solvent-free conditions. This methodol. was established with many advantages, including mild reaction conditions, short reaction times, good yields, simple work-up procedures and environmental friendliness.

RSC Advances published new progress about Condensation reaction. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Safety of Morpholine-4-sulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Venkateswarlu, Somepalli; Satyanarayana, Meka; Lakshmikanthan, Vijaybaskar; Siddaiah, Vidavalur published the artcile< Fused Quinazolinoquinazolinones: Synthesis, Isomerization, Spectroscopic Identification, and Anticancer Activity>, Quality Control of 5004-88-6, the main research area is EGFR tyrosine kinase anticancer fused quinazolino quinazolinone; fused quinazolino quinazolinone preparation anticancer.

13H-quinazolino[3,4-a]quinazolin-13-ones have been synthesized from 2-aminobenzamides in four steps. An acid-catalyzed or base-catalyzed isomerization of 13H-quinazolino[3,4-a]quinazolin-13-ones to 8H-quinazolino[4,3-b]quinazolin-8-ones in excellent yields (90-95%) has been reported. The differences in the IR and NMR (1H & 13C) data of these isomeric fused quinazolinoquinazolinones afford a useful method for distinguishing between the two series. These analogs showed moderate anticancer activity (EGFR-TK inhibition).

Journal of Heterocyclic Chemistry published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Quality Control of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics