Tag: M.W=150-200

Liu, Zhen; Zhang, Yan-Shun; Wei, Yin; Shi, Min published the artcile< Metal-Free Synthesis of Polysubstituted Imidazolinone Through Cyclization of Amidines with 2-Substituted Acrylates>, COA of Formula: C6H6ClNO2S, the main research area is imidazolinone preparation; nucleophilic cyclization benzamidine sulfonylaminoacrylate.

Imidazolidinones such as I (R = 4-MeC6H4, 4-EtC6H4, 4-t-BuC6H4, 4-MeOC6H4, Ph, 4-O2NC6H4, 2-O2NC6H4, 4-FC6H4, 2-ClC6H4, 4-BrC6H4) were prepared by nucleophilic cyclization reaction of (sulfonylamino)acrylates H2CC(NHSO2R)CO2R1 (R = 4-MeC6H4, 4-EtC6H4, 4-t-BuC6H4, 4-MeOC6H4, Ph, 4-O2NC6H4, 2-O2NC6H4, 4-FC6H4, 2-ClC6H4, 4-BrC6H4; R1 = Me, Et, Ph, PhCH2) with benzamidines such as N-phenylbenzamidine in 1,2-dichloroethane at ambient temperature

European Journal of Organic Chemistry published new progress about Benzamidines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, COA of Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Deepak K.; Adams, Spencer T.; Liebmann, Kate L.; Choi, Adam; Miller, Stephen C. published the artcile< Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes>, Formula: C6H6ClNO2S, the main research area is sulfonamide firefly luciferase bioluminescence fluorescent dye.

Many fluorophores, and all bright light-emitting substrates for firefly luciferase, contain hydroxyl or amine electron donors. Sulfonamides were found to be capable of serving as replacements for these canonical groups. Unlike “”caged”” carboxamides, sulfonamide donors enable bioluminescence, and sulfonamidyl luciferins, coumarins, rhodols, and rhodamines are fluorescent in water.

Organic Letters published new progress about Absorptivity. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Diaper, C. M. published the artcile< Other tetrahetero-substituted methanes>, COA of Formula: C9H12N2O3, the main research area is review hetero methane derivative preparation organic synthesis.

A review of the preparation and synthetic applications of tetrahetero-substituted methanes.

Science of Synthesis published new progress about 5004-88-6. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, COA of Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ravindranathan, Krishna; Tirado-Rives, Julian; Jorgensen, William L.; Guimaraes, Cristiano R. W. published the artcile< Improving MM-GB/SA Scoring through the Application of the Variable Dielectric Model>, Synthetic Route of 1524-40-9, the main research area is dielec constant scoring model protein ligand electrostatics; CDK2 Factor Xa p38 PDE10A carbonic anhydrase drug target.

A variable dielec. model based on residue types for better description of protein-ligand electrostatics in MM-GBSA scoring is reported. The variable dielec. approach provides better correlation with binding data and reduces the score dynamic range, typically observed in the standard MM-GB/SA method. The latter supports the view that exaggerated enthalpic separation between weak and potent compounds due to the lack of shielding effects in the model is greatly responsible for the wide scoring spread.

Journal of Chemical Theory and Computation published new progress about Dielectric constant. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Synthetic Route of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Wei; Wu, Ge; Gao, Wenxia; Ding, Jinchang; Huang, Xiaobo; Liu, Miaochang; Wu, Huayue published the artcile< Palladium-catalyzed oxidative C=C bond cleavage with molecular oxygen: one-pot synthesis of quinazolinones from 2-amino benzamides and alkenes>, Synthetic Route of 5004-88-6, the main research area is aminobenzamide alkene palladium catalyst one pot tandem reaction; arylquinazolinone preparation green chem.

Palladium-catalyzed oxidative cleavage/cyclization was disclosed for the concise synthesis of various quinazolinone derivatives from readily available 2-aminobenzamides and terminal alkenes with excellent functional group tolerance. The synthetic features regarding the use of oxygen as a green oxidant and its utility were illustrated in the synthesis of sildenafil.

Organic Chemistry Frontiers published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hedayatullah, Mir; Hugueny, Jean Claude published the artcile< Regioselective transfer of the sulfamoyl group on aminopyrimidines and -purines>, Application of C4H10N2O3S, the main research area is sulfamoylation aminopyrimidine aminopurine regioselectivity; pentachlorophenyl sulfamate sulfamoylating agent.

The regioselective transfer of the sulfamoyl group, to the exocyclic NH2 group of cytosine, thiamine, adenine and guanine is carried out in 86-98% yield by reaction with C6Cl5O3SNH2 in pyridine at 100°.

Phosphorus and Sulfur and the Related Elements published new progress about Regiochemistry. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application of C4H10N2O3S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vu, Huu-Manh; Yong, Jia-Yuan; Chen, Fei-Wu; Li, Xu-Qin; Shi, Guo-Qing published the artcile< Rhodium-Catalyzed C(sp2)-H Amidation of Azine with Sulfonamides>, Synthetic Route of 1524-40-9, the main research area is regioselective rhodium catalyzed amidation azine sulfonamide.

Direct C-H amidation of azine with sulfonamide was developed for the first time. The reactions proceeded smoothly under benign conditions and gave the corresponding products with high selectivity. This approach shows high regioselectivity, wide substrate scope, and functional group tolerance. Addnl., this transformation can also be scaled up to the gram level. This strategy allows for the direct preparation of ortho-sulfonamide-substituted ketone products, thus providing a good complement to previous C-H amidation.

Journal of Organic Chemistry published new progress about Amidation. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Synthetic Route of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hopkins, Megan D.; Ozmer, Garett L.; Witt, Ryan C.; Brandeburg, Zachary C.; Rogers, David A.; Keating, Claire E.; Petcoff, Presley L.; Sheaff, Robert J.; Lamar, Angus A. published the artcile< PhI(OAc)2 and iodine-mediated synthesis of N-alkyl sulfonamides derived from polycyclic aromatic hydrocarbon scaffolds and determination of their antibacterial and cytotoxic activities>, COA of Formula: C6H6ClNO2S, the main research area is alkyl sulfonamide preparation antibacterial antitumor physicochem human.

The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biol. active small mols. that exploit the high degree of lipophilicity imparted by the PAH unit. Herein, new synthetic method for C-X bond substitution that is speculated to operate via a N-centered radical (NCR) mechanism according to exptl. observations was reported. A series of PAH sulfonamides have been synthesized and their biol. activity has been evaluated against Gram-neg. and Gram-pos. bacterial strains (using a BacTiter-Glo assay) along with a series of mammalian cell lines (using CellTiter-Blue and CellTiter-Glo assays). The viability assays have resulted in the discovery of a number of bactericidal compounds that exhibit potency similar to other well-known antibacterials such as kanamycin and tetracycline, along with the discovery of a luciferase inhibitor. Addnl., the physicochem. and drug-likeness properties of the compounds were determined exptl. and using in silico approaches and the results are presented and discussed within.

Organic & Biomolecular Chemistry published new progress about Antibacterial agents. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, COA of Formula: C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Markushyna, Yevheniia; Schuesslbauer, Christoph M.; Ullrich, Tobias; Guldi, Dirk M.; Antonietti, Markus; Savateev, Aleksandr published the artcile< Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst>, Related Products of 6961-82-6, the main research area is chromoselective synthesis sulfonyl chloride sulfonamide potassium polyheptazine imide photocatalyst; carbon nitride; chromoselective catalysis; organic synthesis; photoredox catalysis; sulfonyl chloride.

Among external stimuli used to promote a chem. reaction, photocatalysis possesses a unique one-light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryl disulfides at green to red light (e.g., S-Ph thioacetate → benzenesulfonyl chloride (93%) under blue light irradiation using HCl in water/MeCN and O2 as electron acceptor). A combination of the neg. charged polyanion, highly pos. potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.

Angewandte Chemie, International Edition published new progress about Arenesulfonyl chlorides Role: SPN (Synthetic Preparation), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Related Products of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alcaraz, Lilian; Bennion, Colin; Morris, James; Meghani, Premji; Thom, Stephen M. published the artcile< Novel N-aryl and N-heteroaryl sulfamide synthesis via palladium cross-coupling>, Quality Control of 25999-04-6, the main research area is sulfonamide aryl halide cross coupling palladium phosphine ligand; aryl sulfonamide preparation; phosphine palladium cross coupling catalyst.

An efficient synthesis of N-aryl and N-heteroaryl sulfamides, e.g., I, via an intermol. palladium-catalyzed coupling process has been developed. The reactions proceeded with good to excellent yields and tolerated a wide range of functional groups.

Organic Letters published new progress about Arenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Quality Control of 25999-04-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics