Tag: M.W=150-200

Baranauskiene, Lina; Skiudaite, Lina; Michailoviene, Vilma; Petrauskas, Vytautas; Matulis, Daumantas published the artcile< Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases>, Safety of o-Chlorobenzenesulfonamide, the main research area is human carbonic anhydrase chlorine benzenesulfonamide thiazide drug affinity.

Twelve carbonic anhydrase (CA) isoforms catalyze carbon dioxide hydration to bicarbonate and acid protons and are responsible for many biol. functions in human body. Despite their vital functions, they are also responsible for, or implicated in, numerous ailments and diseases such as glaucoma, high altitude sickness, and cancer. Because CA isoforms are highly homologous, clin. drugs designed to inhibit enzymic activity of a particular isoform, can also bind to others with similar affinity causing toxic side effects. In this study, the affinities of twelve CA isoforms have been determined for nineteen clin. used drugs used to treat hypertension related diseases, i.e. thiazides, indapamide, and metolazone. Their affinities were determined using a fluorescent thermal shift assay. Stopped flow assay and isothermal titration calorimetry were also employed on a subset of compounds and proteins to confirm inhibition of CA enzymic activity and verify the quant. agreement between different assays. The findings of this study showed that pharmaceuticals could bind to human CA isoforms with variable affinities and inhibit their catalytic activity, even though the drug was intended to interact with a different (non-CA) protein target. Relatively minor structural changes of the compounds may cause significant changes in affinity and selectivity for a particular CA isoform.

PLoS One published new progress about Antidiuretics. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Safety of o-Chlorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Roy, Bivas Chandra; Samim, Sk. Abdus; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Tandem synthesis of quinazolinone scaffolds from 2-aminobenzonitriles using aliphatic alcohol-water system>, COA of Formula: C9H12N2O3, the main research area is aminobenzonitrile aliphatic alc water tandem hydration dehydrogenative coupling; quinazolinone preparation green chem.

Ru(II) complex catalyzed tandem synthesis of quinazolinone derivatives is reported here. In this sustainable protocol, 2-aminobenzonitriles were directly transformed to quinazolinones using alc.-water system. A variety of quinazolinones was successfully synthesized in good to excellent yields by utilizing challenging methanol and aliphatic alcs. The practical applicability of the protocol was extended by preparative scale synthesis of various heterocycles as well as natural products. To understand the mechanism of this protocol, several control experiments and DFT studies were carried out. Based on the DFT calculations, a metal-ligand cooperative mechanism was proposed for this system.

Catalysis Science & Technology published new progress about Aliphatic alcohols Role: NUU (Other Use, Unclassified), PRP (Properties), RCT (Reactant), USES (Uses), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, COA of Formula: C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schierle, Simone; Flauaus, Cathrin; Heitel, Pascal; Willems, Sabine; Schmidt, Jurema; Kaiser, Astrid; Weizel, Lilia; Goebel, Tamara; Kahnt, Astrid S.; Geisslinger, Gerd; Steinhilber, Dieter; Wurglics, Mario; Rovati, G. Enrico; Schmidtko, Achim; Proschak, Ewgenij; Merk, Daniel published the artcile< Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology>, SDS of cas: 1524-40-9, the main research area is zafirlukast urea synthesis antiinflammatory pharmacokinetics PPAR cysteinyl leukotriene receptor.

Multitarget design offers access to bioactive small mols. with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacol. interventions for stable treatment. By minor structural changes, we have developed a close analog of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor γ. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents.

Journal of Medicinal Chemistry published new progress about Cysteinyl leukotriene receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (antagonists). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, SDS of cas: 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V. published the artcile< Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation>, Application of C9H12N2O3, the main research area is alkynylarylquinazolinone derivative preparation; arylquinazolinone ethynylbenziodoxolone alkynylation iridium catalyst.

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

Journal of Organic Chemistry published new progress about Alkynylation. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Application of C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Wei; Li, Yuxin; Zhou, Yunyun; Ma, Yi; Li, Zhengming published the artcile< Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents>, HPLC of Formula: 6961-82-6, the main research area is sulfonyl urea pyrimidinyl preparation plant pathogen antifungal activity.

Herein, three series of novel sulfonylureas (SUs) containing aromatic-substituted pyrimidines I (Ar = 4-methylphenyl, 2-furyl, 2-thienyl; R1 = H, Cl, Br, I; R2 = NO2, COOMe, Cl; R3 = H, NO2) were designed and synthesized according to pharmacophore-combination and bioisosterism strategy. The in vitro fungicidal activities against ten phytopathogenic fungi indicated that most of the title compounds I exhibited broad-spectrum and excellent fungicidal activities. Based on the preliminary fungicidal activities, a CoMFA model was constructed and the 3D-QSAR anal. indicated that either a bulky group around the 5-position of the pyrimidine ring or electropos. group around the 2-position of the benzene ring would be favor to fungicidal activities. In order to study interaction mechanism, compound I (Ar = 2-furyl; R1 = Br; R2 = Cl; R3 = H) was automatically docked into yeast acetohydroxyacid synthase (AHAS) and it further indicated that bearing bulky groups-aryl at the pyrimidine ring was critical to enhance antifungal activities. It revealed that the antifungal activity of derivatives I probably results from the inhibition of fungal AHAS. Thus, the present results strongly showed that SUs should be considered as lead compounds or model mols. to develop novel anti-phytopathogenic fungal agents.

Chinese Chemical Letters published new progress about Agrochemical fungicides. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, HPLC of Formula: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yuan, Shuo; Wang, Bo; Dai, Qing-Qing; Zhang, Xiao-Nan; Zhang, Jing-Ya; Zuo, Jia-Hui; Liu, Hui; Chen, Zhe-Sheng; Li, Guo-Bo; Wang, Shaomeng; Liu, Hong-Min; Yu, Bin published the artcile< Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors>, Related Products of 5004-88-6, the main research area is indolyl quinazoline derivative preparation oral P glycoprotein inhibitor cancer.

The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clin. stage make the development of new P-gp inhibitors challenging and desirable. In this study, we reported our structure-activity relationship studies of 4-indolyl quinazoline, which led to the discovery of a highly effective and orally active P-gp inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Furthermore, YS-370 stimulated the P-gp ATPase activity and had moderate inhibition against CYP3A4. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone. Taken together, our data demonstrate that YS-370 is a promising P-gp inhibitor capable of overcoming MDR and represents a unique scaffold for the development of new P-gp inhibitors.

Journal of Medicinal Chemistry published new progress about Antitumor agent resistance. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Related Products of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vaskevych, Alla I.; Savinchuk, Nataliia O.; Vaskevych, Ruslan I.; Rusanov, Eduard B.; Grygorenko, Oleksandr O.; Vovk, Mykhailo V. published the artcile< The PIFA-initiated oxidative cyclization of 2-(3-butenyl)quinazolin-4(3H)-ones - an efficient approach to 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones>, Application In Synthesis of 5004-88-6, the main research area is hydroxymethyl dihydropyrroloquinazolinone preparation regioselective; butenyl quinazolinone oxidative exo trig cyclization PIFA; [bis(trifluoroacetoxy)iodo]benzene PIFA; nitrogen heterocycles; oxidative cyclization; pyrrolo[1,2-a]quinazolines.

A regioselective method for the synthesis of 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones – close structural analogs of naturally occurring vasicinone alkaloids – is described. The procedure is based on PIFA-initiated oxidative 5-exo-trig cyclization of 2-(3-butenyl)quinazolin-4(3H)-ones, in turn prepared by thermal cyclocondensation of the corresponding 2-(pent-4-enamido)benzamides. The products obtained have a good natural product likeness (NPL) score and therefore can be useful for the design of natural product-like compound libraries.

Beilstein Journal of Organic Chemistry published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Application In Synthesis of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xing-Ping; Narla, Rama Krishna; Uckun, Fatih M. published the artcile< Organic phenyl arsonic acid compounds with potent antileukemic activity>, Product Details of C9H12N2O3, the main research area is phenyl arsonic acid quinazoline preparation potent antileukemic activity; chlorodimethoxyquinazoline condensation reaction aminophenylazo phenylarsonic acid.

12 Organic arsonic acid compounds, e.g. I, were synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. E.g., I was prepared from condensation of 4-chloro-6,7-dimethoxyquinazoline and 4-(4′-aminophenylazo)phenylarsonic acid. The lead compounds 2-trichloromethyl-4-[4′-(4”-phenylazo)phenylarsonic acid]aminoquinazoline (compound 19, PHI-P518; IC50=1.1 ± 0.5 μM against NALM-6 and 2.0 ± 0.8 μM against MOLT-3) and 2-methylthio-4-(2′-phenylarsonic acid)aminopyrimidine (compound 15, PHI-P381; IC50=1.5 ± 0.3 μM against NALM-6 and 2.3 ± 0.5 μM against MOLT-3) exhibited potent antileukemic activity at low micromolar concentrations

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Product Details of C9H12N2O3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lange, Jos H. M.; Van Stuivenberg, Herman H.; Veerman, Willem; Wals, Henri C.; Stork, Bob; Coolen, Hein K. A. C.; McCreary, Andrew C.; Adolfs, Tiny J. P.; Kruse, Chris G. published the artcile< Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity>, Application In Synthesis of 25999-04-6, the main research area is aminosulfonyl isothiocyanate diarylpyrazoline addition; aminosulfonylcarbamoyl diarylpyrazoline preparation chlorination amination; diarylpyrazoline derivative cannabinoid CB1 receptor antagonist.

3,4-Diarylpyrazolines as potent CB1 receptor antagonists with lipophilicity lower than that of SLV319 are described. The key change was the replacement of the arylsulfonyl group in the original series by a dialkylaminosulfonyl moiety. The absolute configuration (4S) of enantiomer I was established by X-ray diffraction anal. and I showed a close mol. fit with rimonabant in a CB1 receptor-based model. II exhibited the highest CB1 receptor affinity (Ki = 24 nM) in this series, as well as very potent CB1 antagonistic activity (pA 2 = 8.8) and a high CB1/CB2 subtype selectivity (∼147-fold).

Bioorganic & Medicinal Chemistry Letters published new progress about Cannabinoid receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application In Synthesis of 25999-04-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Yan-Shun; Gui, Hou-Ze; Wei, Yin; Shi, Min published the artcile< Synthesis of Dihydro-2-oxopyrrole (DPO) Building Blocks Catalyzed by Potassium Carbonate>, HPLC of Formula: 1524-40-9, the main research area is dihydro oxopyrrole preparation cascade dimerization cyclization sulfonaminoacrylate; potassium carbonate catalyzed cascade dimerization cyclization sulfonaminoacrylate.

A dimerization and cyclization cascade reaction of 2-sulfonaminoacrylates catalyzed by K2CO3 provides dihydro-2-oxopyrrole (DPO) derivatives This straightforward and atom-economic transformation features a simple exptl. operation with easily available starting materials, a broad substrate scope as well as good functional group tolerance. The desired DPO building blocks are obtained in moderate to good yields.

European Journal of Organic Chemistry published new progress about Atom economy. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, HPLC of Formula: 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics