Tag: M.W=150-200

Zhu, Fengjuan; Song, Runjiang; Li, Shen; Shao, Xusheng published the artcile< In-Water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides>, Name: 2-Amino-4,5-dimethoxybenzamide, the main research area is quinazolinone preparation; dichloronitroethene cyclization anthranilamide water solvent.

An efficient synthetic methodol. was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts.

Synlett published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent) (2-amino). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Name: 2-Amino-4,5-dimethoxybenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Basson, Ashley J.; McLaughlin, Mark G. published the artcile< Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions>, Computed Properties of 1524-40-9, the main research area is calcium catalyst acyliminium ion hydroxyisoindolinone nucleophilic addition; isoindolinone preparation.

Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.

Journal of Organic Chemistry published new progress about Nucleophilic addition reaction. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Computed Properties of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wei, Kajia; Cao, Xiaoxin; Gu, Wancong; Liang, Peng; Huang, Xia; Zhang, Xiaoyuan published the artcile< Ni-Induced C-Al2O3-Framework (NiCAF) Supported Core-Multishell Catalysts for Efficient Catalytic Ozonation: A Structure-to-Performance Study>, Reference of 6961-82-6, the main research area is nickel carbon aluminum framework catalytic ozonation wastewater treatment.

During catalytic ozonation, Al2O3-supported catalysts usually have stable structures but relatively low surface activity, while carbon-supported catalysts are opposite. To encourage their synergisms, we designed a Ni-induced C-Al2O2-framework (NiCAF) and reinforced it with a Cu-Co bimetal to create an efficient catalyst (CuCo/NiCAF) with a core-multishell structure. The partial graphitization of carbon adjacent to Ni crystals formed a strong out-shell on the catalyst surface. The rate constant for total organic carbon removal of CuCo/NiCAF (0.172 ± 0.018 min-1) was 67% and 310% higher than that of Al2O3-supported catalysts and Al2O3 alone, resp. The metals on CuCo/NiCAF contributed to surface-mediated reactions during catalytic ozonation, while the embedded carbon enhanced reactions within the solid-liquid boundary layer and in the bulk solution Moreover, carbon embedment provided a 76% increase in ·OH-production efficiency and an 86% increase in organic-adsorption capacity compared to Al2O3-supported catalysts. During the long-term treatment of coal-gasification wastewater (∼5 m3 day-1), the pilot-scale demonstration of CuCo/NiCAF-catalyzed ozonation revealed a 120% increase in ozone-utilization efficiency (ΔCOD/ΔO3 = 2.12) compared to that of pure ozonation (0.96). These findings highlight catalysts supported on NiCAF as a facile and efficient approach to achieve both high catalytic activity and excellent structural stability, demonstrating that they are highly viable for practical applications.

Environmental Science & Technology published new progress about Acids Role: PEP (Physical, Engineering or Chemical Process), POL (Pollutant), REM (Removal or Disposal), PROC (Process), OCCU (Occurrence). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Reference of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Yanwei; Liu, Hongxin; Li, Bin; Wang, Baiquan published the artcile< Rhodium(III)-catalyzed Intermolecular Unactivated Secondary C(sp3)-H Bond Amidation Directed by 3,5-dimethylpyrazole>, Application of C6H6ClNO2S, the main research area is pyrazole carboxamide preparation; sulfonyl urea preparation; alkylamide sulfonamine amidation rhodium catalyst.

A Rh(III)-catalyzed intermol. unactivated secondary C(sp3)-H bond amidation via nitrene insertion directed by 3,5-dimethylpyrazole has been reported. This procedure tolerates a broad substrate scope including chain and cyclic N-alkylamides, e.g., N-(sec-butyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide. Notably, the directing group 3,5-dimethylpyrazole of chain N-alkylamide substrates could be easily removed via cascade intermol. amidation and intramol. cyclization in one-pot affording sulfonylureas such as I by increasing the reaction temperature

Advanced Synthesis & Catalysis published new progress about Amidation (regioselective). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Krishnamurthy, Vijay M.; Bohall, Brooks R.; Kim, Chu-Young; Moustakas, Demetri T.; Christianson, David W.; Whitesides, George M. published the artcile< Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II>, COA of Formula: C6H6FNO2S, the main research area is thermodn crystal structure fluorinated benzenesulfonamide carbonic anhydrase.

This paper describes a calorimetric study of the association of a series of seven fluorinated benzenesulfonamide ligands (C6HnF5-nSO2NH2) with bovine carbonic anhydrase II (BCA). Quant. structure-activity relationships between the free energy, enthalpy, and entropy of binding and pKa and logP of the ligands allowed the evaluation of the thermodn. parameters in terms of the two independent effects of fluorination on the ligand: its electrostatic potential and its hydrophobicity. The parameters were partitioned to the three different structural interactions between the ligand and BCA: the ZnII cofactor-sulfon-amide bond (≈65% of the free energy of binding), the hydrogen bonds between the ligand and BCA (≈10%), and the contacts between the Ph ring of the ligand and BCA (≈25%). Calorimetry revealed that all of the ligands studied bind in a 1:1 stoichiometry with BCA; this result was confirmed by 19F NMR spectroscopy and X-ray crystallog. (for complexes with human carbonic anhydrase II).

Chemistry – An Asian Journal published new progress about Conformation. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, COA of Formula: C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moukha-Chafiq, Omar; Reynolds, Robert C. published the artcile< Synthesis and General Biological Activity of a Small Adenosine-5'-(Carboxamide and Sulfanilamide) Library>, Safety of 3-Fluorobenzenesulfonamide, the main research area is preparation screening adenosine carboxamide sulfanilamide library; Adenosine peptide analogs; specific or general biological activities.

A small library of fifty-five adenosine peptide analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from 2′,3′-O-isopropylideneadenosine-5′-carboxylic acid . The coupling of amine or sulfanilamide reactants to the free 5′-carboxylic acid moiety of , in automated solution-phase fashion, led after acid-mediated hydrolysis to target compounds in good yields and high purity. No marked anticancer or antimalarial activity was noted on preliminary cellular testing. Initial screening through the MLPCN program, however, indicates that these analogs may show diverse and interesting biol. activities.

Nucleosides, Nucleotides & Nucleic Acids published new progress about Antimalarials. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Safety of 3-Fluorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yamaguchi, Hachiro; Tsujihara, Kenji published the artcile< Sulfonyl diamide derivatives. II. Amide exchange reaction of sulfonyl diamide>, Application In Synthesis of 25999-04-6, the main research area is exchange amine sulfonyl diamide.

In the amide exchange reaction of sulfonyl diamide with amines, the reaction with primary amines under anhydrous conditions gave monosubstituted products at first and then N,N’-disubstituted products. However, the reaction with primary amines under aqueous conditions and with secondary amines in the absence of water gave only mono substituted products. The first intermediates were N-monosubstituted sulfonyl diamides in the case of primary amines, and N,N’-disubstituted sulfonyl diamides in the case of secondary amines. 1,3-Disubstituted imidodisulfonyl diamide was isolated as an intermediate from the reaction under anhydrous conditions, and 1-monosubstituted imidodisulfonyl diamide was isolated as an intermediate from the reaction under aqueous conditions. The former reacted with anhydrous primary amine to give N,N’-disubstituted sulfonyl diamide. The latter reacted with aqueous primary amine to give N-monosubstituted sulfonyl diamide.

Nippon Kagaku Kaishi published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application In Synthesis of 25999-04-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Daniel, Alyssa; Kim, Kelly; Shanmugam, Neel; Sinha, Sneha; Varadharajan, Advika; Acree, William E. published the artcile< Abraham model correlations for solute transfer into cyclopentanone>, SDS of cas: 6961-82-6, the main research area is cyclopentanone anthracene pyrene Abraham model correlation.

Mole fraction solubilities have been measured for anthracene, benzoic acid, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 2-hydroxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 3-nitrobenzoic acid and pyrene dissolved in cyclopentanone at 298.15 K using either spectrophotometric or acid-base titrimetric methods. Results of our exptl. measurements, combined with published solubility data for several inorganic and organic gases, solubility data for several important crystalline pharmaceutical intermediates and activity coefficient data taken from the published literature, were used to derive Abraham model correlations for solute transfer into anhydrous cyclopentanone solvent from both water and from the gas phase. The derived Abraham model correlations back-calculate the observed exptl. data to within 0.10 log units (or less). Reported for the first time are solute descriptor values for several important pharmaceutical intermediates.

Physics and Chemistry of Liquids published new progress about Regression analysis. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Scott, Andrew D.; Phillips, Chris; Alex, Alexander; Flocco, Maria; Bent, Andrew; Randall, Amy; O’Brien, Ronan; Damian, Luminita; Jones, Lyn H. published the artcile< Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors>, Name: 3-Fluorobenzenesulfonamide, the main research area is benzene sulfonamide preparation carbonic anhydrase crystal structure thermodn binding.

The only method that directly measures the thermodn. of a binding event in solution is isothermal titration calorimetry (ITC). We chose human carbonic anhydrase (hCA II) as a favorable system for this investigation as there is already a wealth of both 3D structures and calorimetric data available, which has established this protein as the leading model system. The binding of BSA to hCA II is driven mainly through four H bonds from the sulfonamide, two H bonds to the Zn co-factor (which is itself coordinated by three histidine residues: His94, His96 and His119) and two H bonds to Thr199. ITC anal. was performed on seventeen benzenesulfonamide derivatives (1-17) and three benzylamide para-substituted benzene sulfonamides (18-20) by titration into hCA II. In the case described, ITC measurements, along with X-ray structural studies, indicated that one compound (2-F, 2) was binding to its target by specific (polar) interactions, as opposed to hydrophobicity (e.g. 3-F), and this ultimately led to a higher affinity lead-like compound that retained the enthalpic advantage of the smaller core compound It should be noted that in this case, the compounds chosen were small, fragment-like (< 250 Da) compounds with relatively high affinity for the target, limited flexibility, and a low number of possible interactions (i.e., typical compounds found in fragment libraries), and are therefore related to the concept of ""ligand efficient"" compounds These compounds are ideal for this type of anal. and the utilization of this approach for larger, lower affinity compounds, where the degree of complexity in the thermodn. is substantially greater, requires further investigation. ChemMedChem published new progress about Carbonic anhydrase inhibitors. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Name: 3-Fluorobenzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Narasimhamurthy, Kereyagalahally H.; Chandrappa, Siddappa; Sharath Kumar, Kothanahally S.; Harsha, Kachigere B.; Ananda, Hanumappa; Rangappa, Kanchugarakoppal S. published the artcile< Easy access for the synthesis of 2-aryl 2,3-dihydroquinazolin-4(1H)-ones using gem-dibromomethylarenes as synthetic aldehyde equivalent>, Recommanded Product: 2-Amino-4,5-dimethoxybenzamide, the main research area is quinazolinone dihydro aryl preparation.

One step synthesis of 2,3-dihydroquinazolin-4(1H)-ones I (R = H, Cl, OCH3; R1 = H, Br, Cl, OCH3; Ar = 3-ClC6H4, 4-pyridyl, 4-CF3C6H4, etc.) from gem-dibromomethylarenes ArCH(Br)2 using 2-aminobenzamide is described. Gem-dibromomethylarenes are used as aldehyde equivalent for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones, this synthesis takes shorter reaction time with quick isolation and excellent product yield.

RSC Advances published new progress about Amino amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Recommanded Product: 2-Amino-4,5-dimethoxybenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics