Tag: M.W=150-200

Zhang, Wei; Yang, Darun; Wang, Wengui; Wang, Shoufeng; Zhao, Huaiqing published the artcile< Iridium(III)-Catalyzed Directed ortho-C(sp2)-H Amidation of Arenes with Sulfonamides>, Product Details of C6H6FNO2S, the main research area is sulfonamido aryl ketoxime ether regioselective preparation; iridium catalyst regioselective amidation aryl ketoxime methyl ether sulfonamide; directed amidation aryl ketoxime methyl ether sulfonamide iridium catalyst.

In the presence of [Cp*IrCl2]2 and AgNTf2, aryl ketoxime O-Me ethers underwent directed regioselective amidation with sulfonamides mediated by AgOAc in CH2Cl2 at 60° to give ortho-(sulfonylamino)aryl ketoxime O-Me ethers.

European Journal of Organic Chemistry published new progress about Amination catalysts (regioselective). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Product Details of C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stroganova, Tatyana A.; Vasilin, Vladimir K.; Zelenskaya, Elena A.; Red’kin, Viktor M.; Krapivin, Gennady D. published the artcile< Some transformations of tertiary N-furfurylamides of aromatic and heteroaromatic carboxylic acids under acidic conditions>, Synthetic Route of 5004-88-6, the main research area is furfurylamide aromatic heteroaromatic carboxylic acid transformation.

Acid-catalyzed transformations of tertiary N-furfurylamides of o-amino substituted aromatic and heteroaromatic carboxylic acids accompanied by elimination of the furfuryl moiety are investigated.

Synthesis published new progress about 5004-88-6. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gou, Quan; Liu, Zining; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man; Cheng, Feixiang; Qin, Jun published the artcile< Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines>, Synthetic Route of 1524-40-9, the main research area is sulfonamide alkylamine copper catalyst diastereoselective coupling; sulfonylformamidine.

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Synthetic Route of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Goodman, Patricia A.; Niehoff, Lisa B.; Uckun, Fatih M. published the artcile< Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells>, Synthetic Route of 5004-88-6, the main research area is gamma irradiation cjun lymphocyte tyrosine kinase.

Exposure of B-lineage lymphoid cells to ionizing radiation induces an elevation of c-jun proto-oncogene mRNA levels. This signal is abrogated by protein-tyrosine kinase (PTK) inhibitors, indicating that activation of an as yet unidentified PTK is mandatory for radiation-induced c-jun expression. Here, we provide exptl. evidence that the cytoplasmic tyrosine kinases BTK, SYK, and LYN are not required for this signal. Lymphoma B-cells rendered deficient for LYN, SYK, or both by targeted gene disruption showed increased c-jun expression levels after radiation exposure, but the magnitude of the stimulation was lower than in wild-type cells. Thus, these PTKs may participate in the generation of an optimal signal. Notably, an inhibitor of JAK-3 (Janus family kinase-3) abrogated radiation-induced c-jun activation, prompting the hypothesis that a chicken homolog of JAK-3 may play a key role in initiation of the radiation-induced c-jun signal in B-lineage lymphoid cells.

Journal of Biological Chemistry published new progress about Animal gene, c-jun Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Synthetic Route of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler, John A.; Wilson, Jennifer A.; Corona, Angela; Le Grice, Stuart F. J.; Tramontano, Enzo published the artcile< Scaffold hopping and optimisation of 3′,4′-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H>, SDS of cas: 5004-88-6, the main research area is HIV1 virus allosteric inhibitors reverse transcriptase RNase H; Bioisosters; HIV-1 virus; RNase H; RNase H allosteric inhibitors; integrase.

Bioisosteric replacement and scaffold hopping are powerful strategies in drug design useful for rationally modifying a hit compound towards novel lead therapeutic agents. Recently, we reported a series of thienopyrimidinones that compromise dynamics at the p66/p51 HIV-1 reverse transcriptase (RT)-associated RNase H (RNase H) dimer interface, thereby allosterically interrupting catalysis by altering the active site geometry. Although they exhibited good submicromolar activity, the isosteric replacement of the thiophene ring, a potential toxicophore, is warranted. Thus, in this article, the most active 2-(3,4-dihydroxyphenyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one was selected as the hit scaffold and several isosteric substitutions of the thiophene ring were performed. A novel series of highly active RNase H allosteric quinazolinone inhibitors was thus obtained. To determine their target selectivity, they were tested against RT-associated RNA-dependent DNA polymerase (RDDP) and integrase (IN). Interestingly, none of the compounds were particularly active on (RDDP) but many displayed micromolar to submicromolar activity against IN.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antiviral agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, SDS of cas: 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Salamoun, JM; Garcia, CJ; Hargett, SR; Murray, JH; Chen, SY; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Tucker, SP; Hoehn, KL; Santos, WL in AMER CHEMICAL SOC published article about FATTY LIVER-DISEASE; DIET-INDUCED OBESITY; OXIDATIVE-PHOSPHORYLATION; METABOLIC-INHIBITORS; INSULIN-RESISTANCE; CANCER-CELLS; DINITROPHENOL; PROTON; MECHANISM; BIOENERGETICS in [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA; [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA; [Chen, Sing-Young; Beretta, Martina; Alexopoulos, Stephanie J.; Shah, Divya P.; Olzomer, Ellen M.; Hoehn, Kyle L.] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 USA; [Tucker, Simon P.] Continuum Biosci Pty Ltd, Sydney, NSW 2035, Australia; [Tucker, Simon P.] Continuum Biosci Inc, Boston, MA 02116 USA in 2020.0, Cited 93.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol core, which utilizes the hydroxy moiety as the proton transporter across the mitochondrial inner membrane. We demonstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a readout. In particular, compound SHS4121705 (12i) displayed an EC50 of 4.3 mu M in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the STAM mouse model of NASH, administration of 12i at 25 mg kg(-1) day(-1) lowered liver triglyceride levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibrosis. Importantly, no changes in body temperature or food intake were observed. As potential treatment of NASH, mitochondrial uncouplers show promise for future development.

Computed Properties of C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. Lu, B; Cheng, Y; Chen, LY; Chen, JR; Xiao, WJ in [Lu, Bin; Cheng, Ying; Chen, Li-Yan; Chen, Jia-Rong; Xiao, Wen-Jing] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China; [Xiao, Wen-Jing] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China published Photoinduced Copper-Catalyzed Radical Aminocarbonylation of Cycloketone Oxime Esters in 2019.0, Cited 79.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A visible light-induced and exogenous photo-sensitizer-free, copper-catalyzed radical aminocarbonylation of cycloketone oxime esters with CO gas and amines is developed. The mild catalytic system involving CuCl and N,N,N-tridentate ligand shows good reactivity and chemo-selectivity, and tolerates a wide range of cycloketone oxime esters and alkyl/aryl amines, giving the corresponding cyanoalkylated amides in moderate to good yields. Preliminary mechanistic studies suggest that the reaction involves a Cu-I/(CuCuIII)-Cu-II/-based catalytic cycle and radical intermediate.

Recommanded Product: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Lu, B; Cheng, Y; Chen, LY; Chen, JR; Xiao, WJ or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about CATALYZED TRANSFER HYDROGENATION; STEREOSELECTIVE TRANSFER SEMIHYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; SITE COBALT CATALYSTS; BORANE-AMINE ADDUCTS; SELECTIVE HYDROGENATION; CONJUGATE REDUCTION; AMMONIA-BORANE; ASYMMETRIC HYDROGENATION, Saw an article supported by the Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFE0132600]; Henan Center for Outstanding Overseas Scientists [GZS2020001]; National Innovation and Entrepreneurship Training Program for College students [201910459064]; Zhengzhou University. COA of Formula: C13H13N. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds has been developed using HBP in and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, are all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H-2 combination, are tolerated. The activity of the reactants was studied and the trends are as follows:styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalystin situgenerated from Pd(OAc)(2) and HBP in extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBP in via in situ HD generation and discrimination.

Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about MEINWALD REARRANGEMENT REACTIONS; PROMOTED REARRANGEMENT; SELECTIVE SYNTHESIS; CONVERSION; CYCLOPROPANES; CARBONYLATION; COMPLEXES; OXIDATION; ALDEHYDES, Saw an article supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) through the Centres of Excellence Severo Ochoa award [CTQ2017-87840-P, CTQ2017-87889-P]; IRB Barcelona through the CERCA Programme of the Catalan Government; MINECO; UAB. Application In Synthesis of Diphenylmethanamine. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Cabre, A; Cabezas-Gimenez, J; Sciortino, G; Ujaque, G; Verdaguer, X; Lledos, A; Riera, A. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The isomerization of epoxides to aldehydes using the readily available Crabtree’s reagent is described. The aldehydes were transformed into synthetically useful amines by a one-pot reductive amination using pyrrolidine as imine-formation catalyst. The reactions worked with low catalyst loadings in very mild conditions. The procedure is operationally simple and tolerates a wide range of functional groups. A DFT study of its mechanism is presented showing that the isomerization takes place via an iridium hydride mechanism with a low energy barrier, in agreement with the mild reaction conditions.

Application In Synthesis of Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. In 2020 J ORG CHEM published article about N-ACYLIMINIUM IONS; OXIDATIVE DECARBOXYLATION; RADICAL CHEMISTRY; ARYL; DERIVATIVES; ALDEHYDES; ALCOHOLS; KETONES; MILD; HYDROGENATION in [Khan, Shah Nawaz; Zaman, Muhammad Kashif; Li, Ruining; Sun, Zhankui] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China; [Sun, Zhankui] Chinese Acad Sci, Huzhou Res & Industrializat Ctr Technol, Huzhou 313000, Peoples R China in 2020, Cited 49. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Welcome to talk about 91-00-9, If you have any questions, you can contact Khan, SN; Zaman, MK; Li, RN; Sun, ZK or send Email.. Recommanded Product: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics