Tag: M.W=150-200

Wu, ZK; Zhai, YY; Zhao, WS; Wei, ZY; Yu, H; Han, S; Wei, YG in [Wu, Zhikang; Zhai, Yongyan; Wei, Zheyu; Yu, Han; Han, Sheng] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Zhao, Wenshu] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai, Peoples R China; [Yu, Han; Wei, Yongge] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China; [Wei, Yongge] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China published An efficient way for the N-formylation of amines by inorganic-ligand supported iron catalysis in 2020, Cited 62. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The first example of an inorganic-ligand supported iron(iii) catalysed coupling of formic acid and amines to form formamides is reported. The pure inorganic catalyst (NH4)(3)[FeMo6O18(OH)(6)] (1), which consists of a central Fe-III single-atomic core supported within a cycle-shaped inorganic ligand consisting of six (MoO6)-O-VI octahedra, shows excellent activity and selectivity, and avoids the use of complicated/commercially unavailable organic ligands. Various primary amines and secondary amines have been successfully transformed into the corresponding formamides under mild conditions, and the formylation of primary diamines has also been achieved for the first time. The Fe catalyst 1 can be reused several times without appreciable loss of activity.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Wu, ZK; Zhai, YY; Zhao, WS; Wei, ZY; Yu, H; Han, S; Wei, YG or concate me.

Reference:
Amide – Wikipedia,
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In 2020.0 ORG PROCESS RES DEV published article about HYDROGEN; BROMIDES; OLEFINS; ARYL in [Kallemeyn, Jeffrey M.; Engstrom, Kenneth M.; Pelc, Matthew J.; Lukin, Kirill A.; Morrill, Westin H.; Wei, Haojuan; Towne, Timothy B.; Henle, Jeremy; Nere, Nandkishor K.; Welch, Dennie S.; Shekhar, Shashank; Ravn, Matthew M.; Zhao, Gang; Fickes, Michael G.; Cink, Russell D.] AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA; [Ding, Chen; Vinci, John C.; Marren, James] AbbVie Inc, Analyt Res & Dev, N Chicago, IL 60064 USA in 2020.0, Cited 35.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Quality Control of Diphenylmethanamine

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

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Amide – Wikipedia,
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Quality Control of Diphenylmethanamine. Authors Ingale, AP; Ukale, D; Garad, DN; Shinde, SV in TAYLOR & FRANCIS INC published article about in [Ingale, Ajit P.] Savitribai Phule Pune Univ, Dada Patil Coll, Dept Chem, Ahmednagar, Maharashtra, India; [Ukale, Dattatraya] Univ Turku, Dept Chem, Turku, Finland; [Garad, Dnyaneshwar N.] Natl Univ Ireland Galway, Sch Chem, Galway, Ireland; [Shinde, Sandeep V.] Swami Ramanand Teerth Marathwada Univ, Pratibha Niketan Coll, Dept Chem, Nanded, India in 2021.0, Cited 17.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Quality Control of Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Ingale, AP; Ukale, D; Garad, DN; Shinde, SV or send Email.

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Amide – Wikipedia,
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An article Photoinduced Copper-Catalyzed Radical Aminocarbonylation of Cycloketone Oxime Esters WOS:000485090400050 published article about C BOND-CLEAVAGE; METAL-FREE; CARBONYLATION REACTIONS; CARBON-MONOXIDE; ALKYL IODIDES; HALIDES; CHEMISTRY; COUPLINGS; ALKENES; SALTS in [Lu, Bin; Cheng, Ying; Chen, Li-Yan; Chen, Jia-Rong; Xiao, Wen-Jing] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China; [Xiao, Wen-Jing] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 79.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A visible light-induced and exogenous photo-sensitizer-free, copper-catalyzed radical aminocarbonylation of cycloketone oxime esters with CO gas and amines is developed. The mild catalytic system involving CuCl and N,N,N-tridentate ligand shows good reactivity and chemo-selectivity, and tolerates a wide range of cycloketone oxime esters and alkyl/aryl amines, giving the corresponding cyanoalkylated amides in moderate to good yields. Preliminary mechanistic studies suggest that the reaction involves a Cu-I/(CuCuIII)-Cu-II/-based catalytic cycle and radical intermediate.

Product Details of 91-00-9. Welcome to talk about 91-00-9, If you have any questions, you can contact Lu, B; Cheng, Y; Chen, LY; Chen, JR; Xiao, WJ or send Email.

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Amide – Wikipedia,
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Authors Shelp, RA; Ciro, A; Pu, YG; Merchant, RR; Hughes, JME; Walsh, PJ in ROYAL SOC CHEMISTRY published article about in [Shelp, Russell A.; Ciro, Anthony; Pu, Youge; Walsh, Patrick J.] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA; [Merchant, Rohan R.] Merck & Co Inc, Dept Discovery Chem, San Francisco, CA 94080 USA; [Hughes, Jonathan M. E.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA in 2021, Cited 41. Recommanded Product: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

We report a 3-component reaction between N-benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates. These structures are analogous to highly sought diarylmethanamine cores, which are common motifs in bioactive molecules. We demonstrate the versatility of the boronate ester handle via downstream functionalization through a variety of reactions, including a challenging Pd-catalyzed (hetero)arylation that exhibits a broad substrate scope. Together, these methods enable the synthesis of high-value BCP benzylamines which are inaccessible by existing methods. Furthermore, we demonstrate the successful application of these newly developed (hetero)arylation conditions to a variety of challenging tertiary pinacol boronates, including nitrogen-containing heterocycles, 1,1-disubstituted cyclopropanes, and other BCP cores.

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Amide – Wikipedia,
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Recently I am researching about MOLECULAR-ORBITAL METHODS; FORCE-FIELD PARAMETERS; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; ENANTIOSELECTIVE ALLYLATION; CYCLOBUTANE BACKBONE; MODULAR LIGANDS; BASIS-SETS; AB-INITIO; ALKYLATION, Saw an article supported by the Spanish Ministry of Economy and Competitiveness [CTQ2016-74878-P]; European Regional Development Fund (AEI/FEDER, UE); Catalan Government [2017SGR1472]; ICREA Foundation (ICREA Academia award). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Recommanded Product: Diphenylmethanamine

A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate X (mol Pd X h)(-1)) and excellent enantioselectivities (ee’s up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson-Khand enyne cyclization.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 SYNTHETIC COMMUN published article about EFFICIENT SYNTHESIS; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; INHIBITORS; CHEMISTRY; SYNTHASE in [Jaganmohan, Chikkanti; Kumar, Vinay K. P.; Venkateshwarlu, R.; Mohanty, Sandeep; Kumar, Jaydeep; Raghunadh, Akula] Dr Reddys Labs Ltd, Hyderabad 500049, India; [Jaganmohan, Chikkanti; Rao, Venkateswara B.] Andhra Univ, Dept Organ Chem & FDW, Visakhapatnam, Andhra Pradesh, India; [Tadiparthi, Krishnaji] CHRIST Deemed Be Univ, Dept Chem, Hosur Rd, Bangalore 560029, Karnataka, India in 2020.0, Cited 41.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Product Details of 91-00-9

A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.

Welcome to talk about 91-00-9, If you have any questions, you can contact Jaganmohan, C; Kumar, KPV; Venkateshwarlu, R; Mohanty, S; Kumar, J; Rao, BV; Raghunadh, A; Tadiparthi, K or send Email.. Product Details of 91-00-9

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about H BOND-CLEAVAGE; N-C CLEAVAGE; SECONDARY AMIDES; CARBOXAMIDES; ACTIVATION, Saw an article supported by the National Research Foundation of Korea (NRF) – Korea Government (MSIT) [NRF-2021R1A2C1005169]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Joseph, D; Park, MS; Lee, S. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. COA of Formula: C13H13N

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

COA of Formula: C13H13N. Welcome to talk about 91-00-9, If you have any questions, you can contact Joseph, D; Park, MS; Lee, S or send Email.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 41.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Name: Diphenylmethanamine. Welcome to talk about 91-00-9, If you have any questions, you can contact Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Zinc Complexes of beta-Ketoiminato Ligands as Efficient Catalysts for the Synthesis of alpha-Amino Nitriles via Strecker Reaction published in 2020.0. Recommanded Product: Diphenylmethanamine, Reprint Addresses Panda, TK (corresponding author), Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

We report the synthesis of alpha-aminonitriles by one-pot coupling reaction of aldehyde, amines and trimethylsilyl cyanide (TMSCN) using beta-ketoiminato zinc complexes as a pre-catalyst in very good yield under mild reaction condition. Homoleptic zinc complex [{kappa(2)-(2,4,6-Me3C6H2NC(Me)=CHC(Me)=O)}(2)Zn] (1 a) was synthesized by the treatment of protic ligand [(2,4,6-Me3C6H2NHC(Me)=CHC(Me)=O)] ((LH)-H-1) with potassium hydride and anhydrous zinc diiodide in 2 : 2 : 1 molar ratio in THF. Analogous reactions using [(2,6-(Pr2C6H3NHC)-Pr-i(Me)=CHC(Me)=O)] ((LH)-H-2) and [(Ph2CHNHC(Me)=CHC(Me)=O)] ((LH)-H-3) as protic ligands, dinuclear zinc complexes [{kappa(3)-(2,6-(Pr2C6H3NC)-Pr-i(Me)=CHC(Me)=O)}ZnI](2)(1 b) and [Zn(Ph2CHNHC-(Me)=CHC(Me)=O)ZnI2] (1 c) were obtained in good yield. Molecular structures of ligandsL(1)H,(LH)-H-3, and zinc complexes1 a,1 b, and1 cwere established by single-crystal x-ray diffraction analysis. Dinuclear zinc complexes1 b, and1 cexhibited high transformation, greater selectivity and broad substrate scope for the synthesis of alpha-aminonitrile under mild condition. A most plausible mechanism for synthesis alpha-aminonitrile is proposed based on several controlled reactions.

Recommanded Product: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics