Tag: M.W=150-200

He, Changyu published the artcileDesign and synthesis of redox and oxidative dual responsive block copolymer micelles for intracellular drug delivery, Formula: C4H6F3NOS, the publication is European Polymer Journal (2016), 38-52, database is CAplus.

The need for smart materials in the area of biotechnol. has accelerated the development of stimuli-responsive copolymer micelles. Here, we reported a novel dual-stimuli-responsive block copolymer PEG-DMTK-SS-PLA with both di-Me thioketal (DMTK) and disulfide linkage incorporated into the backbone, capable of triggering fast drug release properties upon both oxidative (H₂O₂) and reductive (GSH) environment. The CMC values of these copolymer micelles ranging from 0.051 to 0.087 mg mL^-1, the average diameters are from 34 nm to 55 nm and 65 nm to 198 nm for blank and DOX-loaded micelles resp. MTT assay conducted in NIH 3T3 cells showed the low cytotoxicity of these micelles even when the concentration reached up to 500 μg/mL. Considering tumor microenvironment’s diverse in kinds of tumor cells, fluorescence microscopy, flow cytometry and MTT activity anal. were conducted in several cancer cells (e.g., cervix, lung, gastric, and colon cancer cells), and further confirmed that the dual responsive PEG-DMTK-SS-PLA micelles were degraded much faster than that of non-responsive PEG-PLA and single responsive PEG-SS-PLA and PEG-DMTK-PLA micelles. These results indicate that the dual-responsive micelles are promising for efficient anticancer drug delivery.

European Polymer Journal published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Formula: C4H6F3NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Moniruzzaman, Mohammad published the artcileElectrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B₁₂ complex, HPLC of Formula: 360-92-9, the publication is Journal of Porphyrins and Phthalocyanines (2022), 26(6/7), 419-426, database is CAplus.

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochem. method with the B12 complex as a catalyst under mild conditions, in open air at room temperature Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.

Journal of Porphyrins and Phthalocyanines published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, HPLC of Formula: 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shim, Min Suk published the artcileA Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells, Synthetic Route of 1869-45-0, the publication is Angewandte Chemie, International Edition (2013), 52(27), 6926-6929, database is CAplus and MEDLINE.

Thioketal-based I was prepared for targeted gene delivery in prostate cancer. Degradation of thioketal linkages in I under reactive oxygen species conditions led to efficient intracellular release of the complexed DNA in prostate cancer cells. The DNA-I polyplexes exhibited efficient gene transfection. Incorporation of GRP78-binding peptide into I achieved cancer-targeted gene transfection.

Angewandte Chemie, International Edition published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C10H14N2O, Synthetic Route of 1869-45-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhuo, Liang published the artcileAerobic Visible-Light Induced Intermolecular S-N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions, Safety of 3-Methoxybenzothioamide, the publication is European Journal of Organic Chemistry (2021), 2021(23), 3398-3402, database is CAplus.

Aerobic visible-light induced intermol. S-N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles I (R = Ph, 4-methoxyphenyl, thiophen-3-yl, etc.; R¹ = 4-methoxyphenyl, 2,6-dimethylphenyl, thiophen-2-yl, etc.) can be obtained from thioamides R/R¹C(S)NH₂. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S-N bonds.

European Journal of Organic Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C15H24O2, Safety of 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cao, Yu published the artcileSynthesis and activity on bis-ureas of thiadiazole, Computed Properties of 2447-79-2, the publication is Huaxue Shiji (2012), 34(11), 982-984,998, database is CAplus.

Seven new bis-ureas of thiadiazloe derived from 2-amino-5-mercapto-1,3,4-thiadiazole, 1,3-dibromopropane and acyl azides were synthesized and characterized by the phys. constants, elementary anal., IR, and ¹HNMR. The optimal conditions for preparation of bis-ureas of thiadiazloe were as follows: n(bis-ureas of thiadiazloe): n was 1.0:1.0, and the reaction time was 4 h at 40 °C, The product yield of bis-ureas of thiadiazloe could reach 63.5%. The results of biol. activity tests showed that all samples have activity on plant growth hormone and auxin.

Huaxue Shiji published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jiang, Biao-Lin published the artcileCobalt(II)/N,N’,N”-Trihydroxyisocyanuric Acid Catalyzed Aerobic Oxidative Esterification and Amidation of Aldehydes, Formula: C10H14N2O, the publication is Asian Journal of Organic Chemistry (2018), 7(5), 977-983, database is CAplus.

A protocol for a Co^II/N,N’,N”-trihydroxyisocyanuric acid (THICA)-catalyzed aerobic oxidative esterification and amidation of aldehydes has been developed. Preliminary insight into the mechanism indicates that such an oxidative C-O/N cross-coupling reaction proceeds by masking the aldehyde in a nucleophilic addition reaction with an alkoxy/amino source, thereby keeping the highly reactive formyl group from undesired oxidation This protocol for the oxidative esterification and amidation of aldehydes proceeds through two different pathways that are characterized by the intrinsic nucleophilicity of the alkanol and amine substrates. The former occurs in the presence of TsOH as a cocatalyst and orthoformates as the alkoxy sources, instead of alkanols, to efficiently afford the transient acetals. In contrast, the coupling of the more nucleophilic amines with aldehydes renders a readily accessible cross-coupling reaction that occurs without any cocatalyst but is limited by the potential inhibition of THICA upon nucleophilic substitution by an amine. Consequently, only sterically hindered amines were tolerated in this catalytic system, whereas further condensation occurred in the presence of primary amines to lead to imines.

Asian Journal of Organic Chemistry published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Cheng, Chuanjie published the artcileA highly efficient Pd-C catalytic hydrogenation of pyridine nucleus under mild conditions, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Tetrahedron (2009), 65(41), 8538-8541, database is CAplus.

A synergistic Pd-C catalytic hydrogenation of 4-pyridinecarboxamides straightforwardly to 4-piperidinecarboxamide hydrochlorides was developed in the presence of ClCH₂CHCl₂. It provided a novel strategy for highly efficient hydrogenation of pyridine nuclear by using low-cost Pd-C catalyst under mild conditions.

Tetrahedron published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dermenci, Alpay published the artcileRh-catalyzed decarbonylation of conjugated ynones via carbon-alkyne bond activation: reaction scope and mechanistic exploration via DFT calculations, Name: N-Methoxy-N-methylisonicotinamide, the publication is Chemical Science (2015), 6(5), 3201-3210, database is CAplus and MEDLINE.

Detailed development of a catalytic decarbonylation of conjugated monoynones to synthesize disubstituted alkynes was described. The reaction scope and limitation has been thoroughly investigated, and a broad range of functional groups including heterocycles were compatible under the catalytic conditions. Mechanistic exploration via DFT calculations has also been executed. Through the computational study, a proposed catalytic mechanism has been carefully evaluated. These efforts are expected to serve as an important exploratory study for developing catalytic alkyne-transfer reactions via carbon-alkyne bond activation.

Chemical Science published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Name: N-Methoxy-N-methylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lawrence, Elliot J. published the artcile3-Aryl-3-(trifluoromethyl)diazirines as Versatile Photoactivated “Linker” Molecules for the Improved Covalent Modification of Graphitic and Carbon Nanotube Surfaces, Product Details of C6H10F3NO, the publication is Chemistry of Materials (2011), 23(16), 3740-3751, database is CAplus.

3-Aryl-3-(trifluoromethyl)diazirines are shown to be synthetically useful photoactivated carbene precursors that can be used as mol. “tethers” to facilitate the improved covalent surface modification of graphitic carbon and carbon nanotubes with a potentially large variety of chem. species. Proof-of-concept is demonstrated by the synthesis, as well as spectroscopic and electrochem. characterization, followed by photoactivated attachment of the organometallic diazirine derivative, 3-[3-(trifluoromethyl)diazirin-3-yl]phenyl ferrocene monocarboxylate, to the surface of vitreous carbon, and also to two different morphologies of multiwalled carbon nanotubes (“bamboo-like” and “hollow-tube”, denoted as b-MWCNTs and h-MWCNTs, resp.). The latter differ only in the relative amounts of “edge-plane-like” defect sites (at the termini of the nanotubes) and “basal-plane-like” pristine sidewall regions. The facile covalent coupling of the ferrocenyl “probe” moiety to the diazirine “linker” was confirmed by UV-vis, ¹H and ¹⁹F NMR spectroscopy, and cyclic voltammetry (CV). Upon exposure to UV irradiation in the presence of graphitic materials, the resulting covalent surface attachment of the ferrocenyl groups via the diazirine “linker” was characterized by Raman and XPS and by CV experiments performed in nonaqueous electrolyte. The surface coverage of 3-[3-(trifluoromethyl)diazirin-3-yl]phenyl ferrocene monocarboxylate, analyzed from both CV and XPS experiments was found to be 7%-11% of that estimated for a complete monolayer, and was 20-fold greater than that achieved in control experiments that employed conventional covalent modification strategies to form esters between ferrocene methanol and surface carboxylate groups on the graphitic materials. The surface loading of ferrocene groups on the b-MWCNTs was found to be only ca. 60%-70% that achieved on h-MWCNTs, reflecting the ability of the functionalized carbene intermediate formed upon photolysis of the parent diazirine to insert into C=C bonds in the otherwise relatively inert sidewalls of the nanotubes. This was further confirmed by Raman spectroscopic characterization, which revealed that the h-MWCNTs experienced significantly more sidewall functionalization than the b-MWCNTs, yet still retained good electronic conduction in electrochem. experiments The relative chem. stability of 3-aryl-3-(trifluoromethyl)diazirines, the ease with which they can be potentially be coupled to a large range of different organic, inorganic, and biol. species, and the enhanced surface loading that can be achieved as a result of the reactive carbene intermediate formed during their photolysis, render diazirines highly versatile and potent “linker” mols. for the development of chem. modified materials.

Chemistry of Materials published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pierens, Raymond K. published the artcileThe dipole moments, molar Kerr constants, and solution-state conformation of some substituted benzamides, HPLC of Formula: 2447-79-2, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1980), 235-8, database is CAplus.

The dipole moments and molar Kerr constants were determined for 24 substituted benzamides in dioxane, and discussed in relation to preferred solution conformations. The results indicate that for a given ring substituent the dihedral angle between the planar amide group and the benzene ring is similar for both the 3- and 4-substituted benzamides but less than that for the 2-substituted isomer. For the 3-substituted benzamides both cis and trans conformers contribute to the observed dipole moment and molar Kerr constant whereas for the 2-substituted species only that conformer contributes which has the amide C:O bond remote from the ortho substituent.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics