Tag: M.W=200-250

Ito, Sohei published the artcileLeukotriene B₄/leukotriene B₄ receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin, SDS of cas: 321673-30-7, the publication is Shock (2008), 30(1), 87-91, database is CAplus and MEDLINE.

Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. However, the contribution of LTB₄ to liver microcirculatory dysfunction during endotoxemia remains unknown. LTB₄ receptor (BLT1) has been identified as a high-affinity receptor specific for LTB₄. The present study was conducted to examine the roles of LTB₄ and BLT1 in hepatic microcirculatory dysfunction elicited by LPS in mice. The number of leukocytes adhering to the endothelial cells of the hepatic microvessels and perfused sinusoids was determined 4 h after the administration of LPS (0.3 mg/kg, i.v.) to male C57Bl6 mice by in vivo microscopy. A 5-LOX synthase inhibitor, AA-861 (10 or 100 mg/kg, s.c), was administered 30 min before LPS injection. BLT1 knockout mice were used to investigate whether LPS-induced hepatic microcirculatory dysfunction is mediated by BLT1 signaling. The expression of 5-LOX, intercellular adhesion mol. (ICAM) 1, and TNF-α in the liver was measured by real-time reverse-transcriptase-polymerase chain reaction. The administration of LPS caused significant accumulation of leukocyte adhesion to the hepatic microvessels and reduced sinusoidal perfusion when compared with saline-treated mice. The hepatic microcirculatory dysfunction elicited by LPS was minimized in mice pretreated with AA-861 or in BLT1 knockout mice. This was associated with the suppression of hepatic expression of 5-LOX, ICAM-1, and TNF-α. These findings suggest that the LTB₄/BLT1 pathway mediates hepatic microcirculatory dysfunction by enhanced expression of ICAM-1 and TNF-α in a murine model of endotoxemia.

Shock published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, SDS of cas: 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rahabi, Mouna published the artcileDivergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Cell Reports (2020), 30(13), 4386-4398.e5, database is CAplus and MEDLINE.

Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents intestinal inflammation, while the lack of mannose receptor (MR) exacerbates it. A marked increase in dectin-1 expression in dextran sulfate sodium (DSS)-exposed MR-deficient mice supports the critical contribution of dectin-1 to colitis outcome. Dectin-1 is crucial for Ly6C^highCCR2^high monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1β (IL-1β) secretion through leukotriene B4 production Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation.

Cell Reports published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zaiter, Samantha S. published the artcileDesigning de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery, HPLC of Formula: 2418-95-3, the publication is Journal of Medicinal Chemistry (2019), 62(2), 742-761, database is CAplus and MEDLINE.

Protein-protein interactions (PPIs) regulate all signaling pathways for cellular function. Developing mols. that modulate PPIs through the interface of their protein surfaces has been a significant challenge and there has been little success controlling PPIs through standard mol. library screening approaches. PPIs control the cell’s protein-folding machinery, and this machinery relies on a multi-protein complex formed with heat shock protein 70 (Hsp70). Described is the design, synthesis, and biol. evaluation of mols. aimed to regulate the interaction between two proteins that are critical to the protein-folding machinery: heat shock protein 70 (Hsp70) and cochaperone heat shock organizing protein (HOP). We report the first class of compounds that directly regulate these two protein-protein interactions and inhibit protein folding events.

Journal of Medicinal Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C27H39ClN2, HPLC of Formula: 2418-95-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Stamou, Aggeliki published the artcileNIPAm-Based Modification of Poly(L-lysine): A pH-Dependent LCST-Type Thermo-Responsive Biodegradable Polymer, Application of H-Lys(Boc)-OH, the publication is Polymers (Basel, Switzerland) (2022), 14(4), 802, database is CAplus and MEDLINE.

Polylysine is a biocompatible, biodegradable, water soluble polypeptide. Thanks to the pendant primary amines it bears, it is susceptible to modification reactions. In this work Poly(L-lysine) (PLL) was partially modified via the effortless free-catalyzed aza-Michael addition reaction at room temperature by grafting N-isopropylacrylamide (NIPAm) moieties onto the amines. The resulting PLL-g-NIPAm exhibited LCST-type thermosensitivity. The LCST can be tuned by the NIPAm content incorporated in the macromols. Importantly, depending on the NIPAm content, LCST is highly dependent on pH and ionic strength due to ionization capability of the remaining free lysine residues. PLL-g-NIPAm constitutes a novel biodegradable LCST polymer that could be used as “smart” block in block copolymers and/or terpolymers, of any macromol. architecture, to design pH/Temperature-responsive self-assemblies (nanocarriers and/or networks) for potential bio-applications.

Polymers (Basel, Switzerland) published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C18H10, Application of H-Lys(Boc)-OH.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Takatori, Kichitaro published the artcileSyntheses of amides derived from heterocyclic acids and heterocyclic amines and their antitumor activities, Application In Synthesis of 51987-99-6, the publication is Yakugaku Zasshi (1976), 96(4), 471-4, database is CAplus and MEDLINE.

Pyridineacetamides I, II (R = 3-, 4-pyridyl) and 12 thiadiazoles (III, R = 3-,4-pyridyl, 2-thienyl, 2-furyl; R1 = H, CHMe2, CH2CHMe2) were prepared from the phenyl esters of heterocyclic acids and heterocyclic amines preparation procedure not given in the original. III (R = 4-pyridyl, R1 = H, CHMe2, CH2CHMe2; R = 3-pyridyl, R1 = CHMe2, R = 2-thienyl, R1 = CHMe2CH2CHMe2; R = 2-furyl, R1 = CHMe2, CH2CHMe2) had slight antitumor activity against Ehrlich ascites carcinoma and crocker sarcoma-180 in mice.

Yakugaku Zasshi published new progress about 51987-99-6. 51987-99-6 belongs to amides-buliding-blocks, auxiliary class Pyridine,Thiadiazole,Amine,Amide,Inhibitor, name is N-(1,3,4-Thiadiazol-2-yl)nicotinamide, and the molecular formula is C42H63O3P, Application In Synthesis of 51987-99-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yokota, Yosuke published the artcileAbsence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems, Synthetic Route of 321673-30-7, the publication is Blood (2012), 120(17), 3444-3454, database is CAplus and MEDLINE.

BLT1 is a high-affinity receptor for leukotriene B4 (LTB4) that is a potent lipid chemoattractant for myeloid leukocytes. The role of LTB4/BLT1 axis in tumor immunol., including cytokine-based tumor vaccine, however, remains unknown. We here demonstrated that BLT1-deficient mice rejected s.c. tumor challenge of GM-CSF gene-transduced WEHI3B (WGM) leukemia cells (KO/WGM) and elicited robust antitumor responses against second tumor challenge with WEHI3B cells. During GM-CSF-induced tumor regression, the defective LTB4/BLT1 signaling significantly reduced tumor-infiltrating myeloid-derived suppressor cells, increased the maturation status of dendritic cells in tumor tissues, enhanced their CD4⁺ T-cell stimulation capacity and migration rate of dendritic cells that had phagocytosed tumor-associated antigens into tumor-draining lymph nodes, suggesting a pos. impact on GM-CSF-sensitized innate immunity. Furthermore, KO/WGM mice displayed activated adaptive immunity by attenuating regulatory CD4⁺ T subsets and increasing numbers of Th17 and memory CD44^hiCD4⁺ T subsets, both of which elicited superior antitumor effects as evidenced by adoptive cell transfer. In vivo depletion assays also revealed that CD4⁺ T cells were the main effectors of the persistent antitumor immunity. Our data collectively underscore a neg. role of LTB4/BLT1 signaling in effective generation and maintenance of GM-CSF-induced antitumor memory CD4⁺ T cells.

Blood published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C28H18O4, Synthetic Route of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hashimoto, Toru published the artcileIridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Cyanamides, Application In Synthesis of 2451-91-4, the publication is Advanced Synthesis & Catalysis (2015), 357(18), 3901-3916, database is CAplus.

The complex [Ir(cod)Cl]₂/DPPF or rac-BINAP is an efficient catalyst for the [2+2+2] cycloaddition of α,ω-diynes with cyanamides. A wide range of cyanamides derived from secondary amines are good coupling partners for α,ω-diynes. The reaction of unsym. α,ω-diynes possessing two different internal alkyne moieties with cyanamides is regioselective. A competitive experiment showed that cyanamide is more reactive than nitrile. This higher reactivity of cyanamide than nitrile was analyzed based on d. functional theory (DFT) calculations at the B3LYP level.

Advanced Synthesis & Catalysis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application In Synthesis of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yasuda, Daisuke published the artcileRole of leukotrienes in various diseases: analyses of the receptor-deficient mice, Formula: C12H23N3S, the publication is Jikken Igaku (2010), 28(20), 3378-3385, database is CAplus.

Leukotriene (LT) is conventionally known as bioactive lipids and play an important role in the innate immune response or allergic reaction to the bacteria, and cysteinyl LT and LTB₄ (LTC₄, LTD₄, LTE₄) will be generally classified based on the difference in production pathway. By the identification of two kinds each of G protein-coupled receptors towards each leukotriene in latter half of 1990, (BLT1, CysLT1 and BLT2, CysLT2) triggered energetic research were promoted and as a result, the role of leukotriene in the body has gradually become clear with a wide range of possibilities. In this paper, the anal. result of mice engineered receptor that has reported in the course of the research and also introduce here the latest findings on the metabolic disease of bone, multiple sclerosis, and reperfusion myocardial ischemia, recent involvement of the LT model in various diseases.

Jikken Igaku published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C7H5Br2F, Formula: C12H23N3S.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Suzuki, K. published the artcileBenzylation of guanidine by phase transfer reaction, Recommanded Product: N,N-Dibenzylcyanamide, the publication is Research Reports of the Faculty of Engineering, Tokyo Denki University (1996), 39-49, database is CAplus.

Phase transfer reaction was studied to apply to the synthesis of substituted guanidines, especially highly alkyl-substituted guanidines. The reaction produced 27 weight% N, N, N’, N’, N”-pentabenzylguanidine using tetra-butylammonium hydrogen sulfate as catalyst. The reaction and byproduct formation mechanism are proposed.

Research Reports of the Faculty of Engineering, Tokyo Denki University published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C5H10O2S, Recommanded Product: N,N-Dibenzylcyanamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zink, Matthias published the artcileAmino Acid-Substituted Dextran-Based Non-Viral Vectors for Gene Delivery, Related Products of amides-buliding-blocks, the publication is Macromolecular Bioscience (2019), 19(8), n/a, database is CAplus and MEDLINE.

To form bio-inspired non-viral vectors for DNA delivery, the polysaccharide dextran is allowed to react with Boc-amino protected amino acids glycine, β-alanine, and L-lysine activated with 1,1′-carbonyldiimidazole and subsequent dextran ester deprotection. A library of such dextran esters is made available to investigate the relationship between polymer structure, complex formation, stability, toxicity, and transfection. Only dextran esters of β-alanine and L-lysine are able to efficiently interact with DNA as shown by dye exclusion assays, to form nanosized complexes (70-110 nm) with pos. zeta potential. With increasing substitution degree and complex charge ratios, the L-lysine esters accomplish more effective binding and protection of DNA against enzymic degradation than β-alanine esters. However, luciferase reporter gene assays reveal higher transfection for β-alanine than for L-lysine esters due to a more effective DNA release and better suited buffing area of the amino groups triggering the endosomal release. Conclusively, β-alanine-substituted dextran derivatives may serve as promising non-viral vectors.

Macromolecular Bioscience published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C5H5NO3S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics