Tag: M.W=200-250

Katritzky, Alan R. published the artcile1-Cyanobenzotriazole: a safe and convenient source of ⁺CN, Related Products of amides-buliding-blocks, the publication is Revue Roumaine de Chimie (1991), 36(4-7), 573-80, database is CAplus.

Readily available 1-cyanobenzotriazole I is a convenient reagent for the conversion of secondary amines R¹R²NH (dioctylamine, dibenzylamine, pyrrolidine, etc.) into the corresponding cyanamides, R¹R²NCN. Exploratory work with primary amines and with mercaptans is also reported.

Revue Roumaine de Chimie published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gerrits, Michael published the artcileSite-Specific Chemoselective Pyrrolysine Analogues Incorporation Using the Cell-Free Protein Synthesis System, Product Details of C11H22N2O4, the publication is ACS Synthetic Biology (2019), 8(2), 381-390, database is CAplus and MEDLINE.

Cell-free protein synthesis (CFPS) is a fast and convenient way to synthesize proteins for anal. studies and applications. CFPS, when equipped with a suitable orthogonal pair, allows for protein-site-directed labeling with desired functionalities such as fluorescent dyes or therapeutic groups that are needed to tailor proteins for anal. applications. In this context, chemoselective reactive pyrrolysine analogs (CR-OAs) are of particular value, as this class of unnatural amino acids, among other useful properties, covers a wide range of different chemoselective reactions. In this study, we present a flexible approach that facilitates incorporation of CR-OAs in CFPS systems. In particular, a fairly simple addition of two expression plasmids in our cell-free system, one encoding pyrrolysyl-tRNA synthetase and the other one the target protein, enabled ribosomal synthesis of proteins in the half-milligram range with the pre-installed orthogonal reactivity, easily modifiable by using mild, copper-free bioorthogonal chem. Our CFPS system allows rapid and highly customizable expression, as shown by several examples of successful site-directed fluorescence labeling. The feasibility of our CFPS system for protein analytics is further proved by demonstrating the functional integrity of a labeled protein by interaction measurements using microscale thermophoresis.

ACS Synthetic Biology published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Product Details of C11H22N2O4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jala, Venkatakrishna R. published the artcileThe yin and yang of leukotriene B₄ mediated inflammation in cancer, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Seminars in Immunology (2017), 58-64, database is CAplus and MEDLINE.

The high affinity leukotriene B₄ receptor, BLT1 mediates chemotaxis of diverse leukocyte subsets to the sites of infection or inflammation. Whereas the pathol. functions of LTB₄/BLT1 axis in allergy, autoimmunity and cardiovascular disorders are well established; its role in cancer is only beginning to emerge. In this review, we summarize recent findings on LTB₄/BLT1 axis enabling distinct outcomes toward tumor progression. In a mouse lung tumor model promoted by silicosis-induced inflammation, genetic deletion of BLT1 attenuated neutrophilic inflammation and tumor promotion. In contrast, in a spontaneous model of intestinal tumorigenesis, absence of BLT1 led to defective mucosal host response, altered microbiota and bacteria dependent colon tumor progression. Furthermore, BLT1 mediated CD8⁺ T cell recruitment was shown to be essential for initiating anti-tumor immunity in number of xenograft models and is critical for effective PD1 based immunotherapy. BLT2 mediated chemotherapy resistance, tumor promotion and metastasis are also discussed. This new information points to a paradigm shift in our understanding of the LTB₄ pathways in cancer.

Seminars in Immunology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gless, Bengt H. published the artcileIdentification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation, Name: H-Lys(Boc)-OH, the publication is Nature Chemistry (2019), 11(5), 463-469, database is CAplus and MEDLINE.

Staphylococci secrete autoinducing peptides (AIPs) as signaling mols. to regulate population-wide behavior. AIPs from non-Staphylococcusaureus staphylococci have received attention as potential antivirulence agents to inhibit quorum sensing and virulence gene expression in the human pathogen Staphylococcus aureus. However, only a limited number of AIP structures from non-S. aureus staphylococci have been identified to date, as the minute amounts secreted in complex media render it difficult. Here, we report a method for the identification of AIPs by exploiting their thiolactone functionality for chemoselective trapping and enrichment of the compounds from the bacterial supernatant. Standard liquid chromatog. mass spectrometry anal., guided by genome sequencing data, then readily provides the AIP identities. Using this approach, we confirm the identity of five known AIPs and identify the AIPs of eleven non-S. aureus species, and we expect that the method should be extendable to AIP-expressing Gram-pos. bacteria beyond the Staphylococcus genus.

Nature Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Name: H-Lys(Boc)-OH.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Margaroli, Camilla published the artcileDistinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Experimental Dermatology (2020), 29(12), 1191-1198, database is CAplus and MEDLINE.

Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by recruitment of leukocytes into skin and release of damaging enzymes, resulting in epidermal detachment and blister formation. To better understand the role of leukotriene B4 (LTB4) and other inflammatory factors in BP pathophysiol., we conducted microscopic and immunohistochem. analyses of preserved skin biopsy sections and conducted flow cytometry and ELISA analyses of matched blood and blister fluid from BP patients. Neutrophils predominated in BP blister fluid, which also contained monocytes/macrophages and T cells, but few to no eosinophils and B cells. In contrast, BP skin histol. showed a different pattern, with abundant neutrophils but eosinophils being the predominant immune cell type. LTB4 pathway and neutrophil activation markers were prevalent in BP skin lesions and strongly associated with perivascular neutrophils. Blister fluid neutrophils, monocytes/macrophages and eosinophils all exhibited increased surface expression of leukotriene A4 hydrolase and neutrophil elastase (P = .002 for both). Blister fluid was also enriched in interleukins (IL)-1α, IL-1β, IL-8, IL-10, IL-18, monocyte colony-stimulating factor (M-CSF) and vascular endothelial growth factor (VEGF). Our findings suggest differential leukocyte recruitment from blood into dermis and from dermis into blister, which correlates with disease activity, and presents potential new treatment opportunities for BP.

Experimental Dermatology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Recommanded Product: [(2-Hexylcyclopentylidene)amino]thiourea.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Youn, So Won published the artcilePd-Catalyzed Intramolecular Oxidative C-H Amination: Synthesis of Carbazoles, Recommanded Product: (2-Pivalamidophenyl)boronic acid, the publication is Organic Letters (2011), 13(14), 3738-3741, database is CAplus and MEDLINE.

A Pd-catalyzed oxidative C-H amination of N-Ts-2-arylanilines under ambient temperature using Oxone as an inexpensive, safe, and easy-to-handle oxidant has been developed. This process represents a green and practical method for the facile construction of carbazoles with a broad substrate scope and wide functional group tolerance.

Organic Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C12H16BClO3, Recommanded Product: (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liang, Honggang published the artcileSynthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines, Computed Properties of 2451-91-4, the publication is Synlett (2017), 28(19), 2675-2679, database is CAplus.

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the com. availability of the starting materials, this new method represented a valuable tool for the synthesis of cyanamides through an N-deallylation reaction and an N-cyanation reaction in one pot.

Synlett published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Computed Properties of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Itagaki, Kiyoshi published the artcileEicosanoid-Induced Store-Operated Calcium Entry in Dendritic Cells, Computed Properties of 321673-30-7, the publication is Journal of Surgical Research (2011), 169(2), 301-310, database is CAplus and MEDLINE.

Background: Eicosanoids are generally recognized to exert potent immunomodulatory properties, including effects on T cell, antigen-presenting cell (APC), and dendritic cell (DC) maturation and function. Since DC maturation and function may also be regulated by store-operated calcium entry (SOCE), we hypothesized that the effects of eicosanoids on DC function may in part be regulated through changes in intracellular calcium. Methods: DC derived from the bone marrow of male Balb/ByJ mice cultured for 7 d in the presence of granulocyte macrophage colony stimulating factor (GM-CSF) and interleukin-4 (IL-4) were used to study the effects of eicosanoids on SOCE and the resulting Ca²⁺ mobilization. Results: The 5-lipoxygenase (5-LO) products leukotriene B₄ (LTB₄) and LTD_4, but not LTC₄, depleted Ca²⁺ from DC endoplasmic reticulum stores. The specificity of LTB₄ and LTD₄ on Ca²⁺ store-depletion was confirmed by the ability of the specific receptor antagonists, LY25583 and MK571, resp., to abrogate Ca²⁺ store depletion. RT-PCR demonstrated DC receptors for LTB₄ (BLT₁ and BLT₂) and the cysteinyl-LTs (CysLT₁, CysLT₂, and GPR17). We also detected transient receptor potential canonical (TRPC) 1, 2, 4, and 6 and stromal interaction mol. 1 (STIM1) on CD11c⁺ DCs, suggesting these proteins also participate in DC SOCE. In contrast, the cyclooxygenase (CO) metabolite PGE₂ had no effect on DC Ca²⁺ mobilization. Conclusions: To our knowledge, these are the first observations of distinct effects of eicosanoids on DC Ca²⁺ mobilization, which may have important implications for the regulation of DC maturation at sites of immune and non-immune inflammation.

Journal of Surgical Research published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Computed Properties of 321673-30-7.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Donetti, Arturo published the artcileMild and effective two-step conversion of disubstituted cyanamides to secondary amines, SDS of cas: 2451-91-4, the publication is Journal of Organic Chemistry (1972), 37(21), 3352-3, database is CAplus.

A convenient procedure was developed to convert disubstituted cyanamides into secondary amines under mild conditions. Disubstituted cyanamides, R2NCN were obtained from the halides and Na cyanamide in Me2SO. Equimolar amounts of R2NCN and KCN refluxed in MeOH, gave the intermediate o-methylisoureas, which were hydrolyzed to secondary amines with dilute HOAc.

Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, SDS of cas: 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pascual-Alfonso, Eva published the artcileEfficient synthesis of the pyrido[2,3,4-kl]acridin-4-one system common to several cytotoxic marine alkaloids, Application of (2-Pivalamidophenyl)boronic acid, the publication is Tetrahedron Letters (2003), 44(32), 6003-6005, database is CAplus.

An efficient, four-step synthesis of the pyrido[2,3,4-kl]acridin-4-one system is described, using a Suzuki coupling of a 4-iodoquinoline and a oxidative demethylation of a dimethoxyquinoline containing an anilino unit with cobalt trifluoride as the key steps.

Tetrahedron Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Application of (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics