Continuously updated synthesis method about 4093-29-2

The synthetic route of Methyl 4-acetamido-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

4093-29-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4093-29-2, name is Methyl 4-acetamido-2-methoxybenzoate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To methyl 4-acetamido-2-methoxybenzoate (299 mg, 1.34 mmol) in acetic anhydride (3 ml) stirred under nitrogen at -10 C was added concentrated nitric acid (0.35 ml) dropwise. After then stirring at 0 C for 10 min the reaction mixture was partitioned between ethyl acetate (20 ml) and water (20 ml). The aqueous layer was further extracted with ethyl acetate (2 x 10 ml) and the combined organic extract washed with saturated sodium bicarbonate solution (2 x 10 ml), brine (2 x 10 ml), dried (MgSO_ and evaporated to give methyl 4-acetamido-2-methoxy-5 -nitrobenzoate (301 mg, 84%) as a dull orange powder. nmr (400 MHz, CDC13) delta 2.33, s, 3H, AcNH; 3.91, s, 3H, 2-MeO or COOMe; 4.03, s, 3H, COOMe or 2-MeO; 8.63, s, IH, H3 or H6; 8.84, s, IH, H6 or H3; 10.89, br, NH.

The synthetic route of Methyl 4-acetamido-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian; WO2011/123890; (2011); A1;,
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Simple exploration of trans-N-Boc-1,4-cyclohexanediamine

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

177906-48-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 177906-48-8, name is trans-N-Boc-1,4-cyclohexanediamine, A new synthetic method of this compound is introduced below.

1.8 g of LiAlH4 was added to a solution of 2.1 g of intermediate 41 in 50 mL of THF, and heated to reflux for 2 hours. After the reaction was completed, 50 mL of saturated ammonium chloride solution was carefully added under an ice bath to quench the reaction. Separate the organic phase, extract the aqueous phase three times with dichloromethane and incorporate the organic phase, It was washed successively with saturated aqueous ammonium chloride solution and saturated brine, and then dried over anhydrous sodium sulfate, The sodium sulfate was removed by filtration and concentrated to obtain the crude product. The crude product was isolated by column chromatography (200-300 mesh silica gel, eluent dichloromethane: methanol = 3: 1) to obtain pure intermediate 42.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ShanghaiTech University; Tao Houchao; Zhao Fei; (85 pag.)CN110894209; (2020); A;,
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Brief introduction of tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, and friends who are interested can also refer to it.

127828-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127828-22-2 name is tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A stirred solution of 4-chloro-3-nitroquinoline (31.4 g, 0.151 mol) in 500 mL of anhydrous CH2Cl2, under N2, was treated with triethylamine (43 mL, 0.308 mol) and tert-butyl 2-(2-aminoethoxy)ethylcarbamate (0.151 mol). After stirring overnight, the reaction mixture was washed with H2O (2¡Á300 mL) and brine (300 mL). The organic portion was dried over Na2SO4 and concentrated to give a bright yellow solid. Recrystallization from ethyl acetate/hexanes gave 43.6 g of tert-butyl 2-{2-[(3-nitroquinolin-4-yl)amino]ethoxy}ethylcarbamate as bright yellow crystals.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, and friends who are interested can also refer to it.

Reference:
Patent; 3M Innovative Properties Company; US6660735; (2003); B2;; ; Patent; 3M Innovative Properties Company; US6664265; (2003); B2;,
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Extracurricular laboratory: Synthetic route of 4-Bromo-2-fluoro-N-methylbenzamide

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

749927-69-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 749927-69-3, name is 4-Bromo-2-fluoro-N-methylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

Copper chloride (12.8 gm) was charged to N,N?-dimethyl Formamide (600 ml) under argon atmosphere at 75-80C. 4-Bromo-2-fluoro-N-methylbenzamide obtained in example 1 (100 g) was charged to the mixture followed by addition of N,N-dimethylaniline (8.35 gm). The reaction mixture was stirred for 15-20 minutes. 2-aminoisobutyric acid (67 gm) was added and again the mixture was stirred for 15-20 minutes at 75-80C. Powdered potassium carbonate (148 gm) was added and stirred for 15 minutes. Water (10 ml) was added and the temperature of the mass was raised to 1 l0C and the mass was stirred for 4- 5 hours at 4-5 hours. The mass was cooled to 30-35C and filtered. The mass was filtered and washed with dimethyl formamide. Dimethyl formamide was distilled out under vacuum and the mass was cooled. Water (700 ml) was added to the mass and pH was adjusted to 13.5 – 14 by using 10% sodium hydroxide solution. MDC (300 ml) was added to the reaction mass and stirred. The layers were separated and aqueous layer was extracted with MDC (300 ml). MDC layer was separated and washed with water (300 ml). All the aqueous layers were combined and pH was adjusted to 2.5-3 by HC1 to precipitate out the product. The mass was stirred and filtered under vacuum. The precipitate was washed with water (100 ml) and suck dried well. The material was dried under vacuum at 55-60C.The dried product 2-[3-fluoro-4-(methylcarbamoyl) anilino]-2-methyl-propanoic acid (135 g) was isolated. Thereafter, the product is tested for HPLC purity which was observed to be 99.4%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AARTI INDUSTRIES LIMITED; DESAI, Parimal Hasmukhlal; SEETHARAMAN, Subramanian; NIKAM, Vikas Hiraman; KAMBLE, Kiran Mohan; (73 pag.)WO2019/106691; (2019); A1;,
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Some tips on 4-(tert-Butyl)benzenesulfonamide

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6292-59-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, A new synthetic method of this compound is introduced below.

EXAMPLE 9; Synthesis of 2-[6-(4-tert-Butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yloxy]-ethanol acetyl ester; In a 3000 ml round-bottom flask under nitrogen atmosphere, 4-tert-butyl-benzenesulfonamide (103 g, 0.480 mol) and potassium carbonate (166 g, 1.200 mol) are suspended in N,N-dimethyl-acetamide (300 ml) and acetonitrile (200 ml) and the mixture is heated at 75-80¡ã C. for about 30 minutes. The reaction mixture is cooled to about 65-70¡ã C. and added with 2-(5-(2-methoxy-phenoxy)-6-chloro-2-(pyrimidin-2-yl)pyrimidin-4-yloxy)ethanol acetyl ester (200 g, 0.480 mol). The mixture is reacted for 96 hours then diluted with water (1500 ml) and cooled at 0-5¡ã C. for at least 1 hour. The solid is filtered, washing with cold water (4.x.250 ml), and dried at about 45-50¡ã C. for 16-18 hours. 213 g of a solid crude are obtained, in 75percent yield. The resulting product is used for the next reaction, as described in Example 7.

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Reference:
Patent; Dipharma Francis S.r.l.; US2009/156811; (2009); A1;,
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Share a compound : 239074-29-4

The chemical industry reduces the impact on the environment during synthesis tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate. I believe this compound will play a more active role in future production and life.

239074-29-4, The chemical industry reduces the impact on the environment during synthesis 239074-29-4, name is tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate, I believe this compound will play a more active role in future production and life.

Trans (4-Amino-cyclohexyl)-acetonitrileTrans Methanesulfonic acid 4-tert-butoxycarbonylamino-cyclohexylmethyl esterTrans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester (3.49 g, 15.0 mmol) in DCM (50 mL) was treated with pyridine (4.98 mL, 60.8 mmol). The mixture was cooled to 0 C and methanesulfonyl chloride (2.36 mL, 30.4 mmol) was added dropwise over 5 minutes. The mixture was stirred at room temperature for 5 hours and then concentrated under vacuum. The residue was partitioned between ethyl acetate and water and the aqueous phase extracted with ethyl acetate (x2). The combined organic extracts were washed with brine, dried with sodium sulfate and concentrated under vacuum. The residue was triturated with cyclohexane then dried under vacuum to give a white solid. Further purification by column chromatography on silica gel (eluting with 1 : 1 cyclohexane/ethyl acetate) gave 4.17 g (90%) of trans methanesulfonic acid 4- tert-butoxycarbonylamino-cyclohexylmethyl ester as a white solid. 1H NMR (400 MHz, CDCI3) delta: 4.37 (br s, 1 H), 4.02 (d, 2 H), 3.39 (br s, 1 H), 3.00 (s, 3 H), 2.11-2.00 (m, 2 H), 1.91-1.81 (m, 2 H), 1.77-1.64 (m, 1 H), 1.43 (s, 9 H), 1.18-1.05 (m, 4 H).

The chemical industry reduces the impact on the environment during synthesis tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HURLEY, Christopher; KULAGOWSKI, Janusz; ZAK, Mark; WO2013/7768; (2013); A1;,
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The important role of 4-(tert-Butyl)benzenesulfonamide

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(tert-Butyl)benzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7, 6292-59-7

To a solution of 4-tert-butyl benzene sulfonamide compound of formula-6 (48 g) in toluene (600 ml), potassium carbonate (35 g) and tetra butyl ammonium bromide (10 g) was added and the reaction mixture was heated to 50¡ãC. A solution of 5-(2- methoxyphenoxy)-2-(2’pyrimidinyl)-4,6-dichloro pyrimidine compound of formula- 5 (60 g) in toluene (1200 ml) was added slowly to the reaction mixture and it was refluxed using dean stark apparatus for 10 hrs. The reaction mixture was cooled to 25¡ãC and acidified with aqueous hydrochloric acid. The reaction mixture was stirred for an hour. The solid obtained was filtered, washed with water and dried to get the title compound. Yield: 87 g

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(tert-Butyl)benzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MSN LABORATORIES LIMITED; WO2009/95933; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analyzing the synthesis route of 6292-59-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6292-59-7, other downstream synthetic routes, hurry up and to see.

A common compound: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 6292-59-7

General procedure: The N-R-sulfonyldithiocarbimate potassium salts were prepared in dimethylformamide (DMF) from the sulfonamides in reaction with carbon disulfide and potassium hydroxide analogously as described in the literature [9,22,23]. Carbon disulfide (10mmol) and potassium hydroxide (20mmol) were added to a solution of the corresponding sulfonamide (10mmol) in DMF (25mL). The mixture was stirred for approximately 4h up to the total consumption of KOH. Upon the addition of 20mL of ice cold ethanol, a yellowish solid is formed. The product was separated by filtration, washed with ice ethanol, ethyl acetate, diethyl ether, and dried under reduced pressure (yields 70-85%, based on the sulfonamide). The compounds 1a-e are described in literature [9,22,23]. The data for the new potassium dithiocarbimates 1f-h are as follows.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6292-59-7, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Vidigal, Antonio E.C.; Rubinger, Mayura M.M.; de Queiroz, Luan F.; da Silva, Lucas F.; Zambolim, Laercio; Guilardi, Silvana; Souza, Rafael A.C.; Ellena, Javier; Wetler, Emiliana B.; Oliveira, Marcelo R.L.; Inorganica Chimica Acta; vol. 486; (2019); p. 724 – 732;,
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Application of 2-(Sulfamoylamino)benzoic acid

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632-24-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 632-24-6, name is 2-(Sulfamoylamino)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2-Sulfamoylbenzoic acid or 3-sulfamoylbenzoic acid(0.25 mmol) was placed in a 25-mL round-bottomed flaskand SOCl2 (3 mL) was added dropwise at 0C with stirring.The reaction mixture was placed in an 80C oil bath andrefluxed for 2 h. The reaction mixture was cooled to roomtemperature and the volatiles were removed in vacuum byrotary evaporation, leaving a light-yellow oil. Separately, thesolution of the benzyl-protected L-proline 4a (60 mg, 0.25mmol) and TEA (56 mg, 0.55 mmol) in anhydrous DCM (5mL) was prepared under argon. The solution of the obtainedbenzoyl chloride in anhydrous DCM (5 mL) was added tothe solution of the L-proline at 0 C and the reaction mixturewas stirred at room temperature until completion. The mixturewas diluted with DCM (70 mL) and washed successivelywith sat. NaHCO3 (60 mL) and brine (60 mL). Theorganic layer was dried over Na2SO4, filtered and concentratedunder reduced pressure. The residue was purified byflash column chromatography (PE: EA=2: 1) to afford 6b or7b.

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Reference:
Article; Liu, Xinyu; Dong, Shengjie; Ma, Yuru; Xu, Hu; Zhao, Hongxia; Gao, Qingzhi; Medicinal Chemistry; vol. 15; 2; (2019); p. 196 – 206;,
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The important role of 830-43-3

Statistics shows that 830-43-3 is playing an increasingly important role. we look forward to future research findings about 4-(Trifluoromethyl)benzenesulfonamide.

830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 830-43-3

In a 20-mL screw-cap vial, 250 mg (0.75 mmol) 2-(2-chlorophenyl)-1-(4-chlorophenyl)- IH-imidazole-4-carboxylic acid, 18.3 mg DMAP (0.15 mmol), 1.25 g PS-Carbodiimide (1.5 mmol) (polystyrene-supported cyclohexylcarbodiimide , Argonaut Technologies Inc. , San Carlos, CA), 169 mg a,a,a-trifluoro-p-toluenesulfonamide (0.75 mmol), and 12 mL dichloromethane were added, and the reaction mixture was mixed by orbital shaking at rt overnight. The reaction mixture was filtered through a filter tube (polypropylene frit), and the filtrate was evaporated under reduced pressure. The crude product was redissolved in 2 mL MeOH and purified by preparative HPLC to give 39.3 mg of N-{ [2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4- yl]carbonyl}-4-(trifluoromethyl)benzenesulfonamide (beige solid, 10% yield). ?H NMR (400 MHz, CD3COCD3) 8 8.25 (d, 2 H), 7.85 (s, 1 H), 7.75 (s, 2H), 7.20-7.40 (m, 6 H), 6.95 (t, 2 H); LC-MS m/z 540 (MH+), retention time 3.36 min (method 2).

Statistics shows that 830-43-3 is playing an increasingly important role. we look forward to future research findings about 4-(Trifluoromethyl)benzenesulfonamide.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/99705; (2005); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics