Tag: M.W=200-300

83948-53-2, name is tert-Butyl N-(3-Bromopropyl)carbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: tert-Butyl N-(3-Bromopropyl)carbamate

In a 25 mL round-bottomed flask, tert-butyl 3-bromopropylcarbamate (1 g, 4.2 mmol) was combined with N,N-dimethylfonnamide (12 ml). Sodium azide (300 mg, 4.62 mmol) was added and the reaction was stirred at 80C for 2 days. The reaction mixture was diluted with diethyl ether, washed with brine, dried over sodium sulfate and concentrated in vacuo to afford (3-azido-propyl)-carbamic acid tert-butyl ester (736 mg, 88%) as a yellow liquid. This liquid was used in the next step without further purification.

The synthetic route of 83948-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LYNCH, Stephen M.; MARTIN, Rainer E.; NEIDHART, Werner; PLANCHER, Jean-Marc; SCHULZ-GASCH, Tanja; WO2014/86663; (2014); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83948-53-2, name is tert-Butyl N-(3-Bromopropyl)carbamate, A new synthetic method of this compound is introduced below., Product Details of 83948-53-2

Step 1 Preparation of Example 5a: (3-Methylamino-propyl)-carbamic Acid tert-butyl Ester Methylamine (100 mL of a 2.00 M solution in THF, 200 mmol) was added to (3-bromo-propyl)-carbamic acid tert-butyl ester (11.2 g, 47.0 mmol) at room temperature under nitrogen and the solution was stirred for 4 h. The resulting suspension was filtered and concentrated under reduced pressure to give 7.58 g (86%) of (3-methylamino-propyl)-carbamic acid tert-butyl ester (5a) as a clear oil. [M+H]+188.94.

The synthetic route of 83948-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KALYPSYS, INC.; US2007/123572; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 579474-47-8, name is tert-Butyl 2-amino-4-fluorophenylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 579474-47-8

Example M5 {4-Fluoro-2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester (Example J2) (170 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl ester (Example K2) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (251 mg). MS (ISP) 450.4 [(M+H)+]; mp 110-115 C.

The synthetic route of 579474-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Adam, Geo; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes; US2003/166639; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19982-07-1, name: N-(3,5-Dimethyladamantan-1-yl)acetamide

[0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of mesitylenewere added to a test tube having an outer diameter of 30 mm to obtain a mixed solution. Then, 1.12 g (11.1 mmol) of97% concentrated sulfuric acid was dropped into the mixed solution in the test tube to obtain a reaction solution. Theobtained reaction solution was stirred at 30C for 3 hours to continue the reaction. Then, 6.09 g of water was added tothe reaction solution to stop the reaction, and an aqueous phase was removed by washing from the reaction solution toobtain a mesitylene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Then, 0.71 g ofsodium hydrate (NaOH) and 9.61 g of 1-hexanol were added to the obtained solution to obtain a reaction solution. The obtained reaction solution was stirred at 130C for 18 hours to hydrolyze 1-acetamido-3,5-dimethyladamantane. Then,in the reaction solution, the generation of memantine was confirmed by GC (reaction yield: 96.2%).

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Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; SHIMO, Tetsuya; EP2949643; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 116091-63-5, name is 2-Methoxy-5-(2-oxopropyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116091-63-5, Safety of 2-Methoxy-5-(2-oxopropyl)benzenesulfonamide

1.2. Hydrogenation on platinum according to EP 0 257 787 (1987); III yield 53% V The catalyst is used in the amount of 1 g/1 mol of ketone, hydrogenation takes place in methanol under normal pressure for 20 hours. For purification to the desired optical purity (below 0.2 %), the substance is purified 4x in acetone and 3x in a mixture of water and acetone.

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Reference:
Patent; ZENTIVA, A.S.; WO2005/75415; (2005); A1;,
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Some common heterocyclic compound, 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate, molecular formula is C12H18N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: tert-Butyl 3-aminobenzylcarbamate

a) fert-Butyl 3-((7-chloro-5-hydroxy-1 ,1 -dioxido-2H-benzo[e][1 ,2,4]thiadiazin-3- yl)amino)benzylcarbamate (3107) To a stirred solution of 3-bromo-7-chloro-5-hydroxy-2H-benzo[e][1 ,2,4]thiadiazine 1 ,1 – dioxide (lnt-3, 400 mg) in fe/f-butanol (15 mL) at room temperature in a sealed tube were added fe/ -butyl 3-aminobenzylcarbamate (342 mg) and potassium dihydrogenphosphate (210 mg). The reaction mixture was warmed to 100 C for 16 h. The reaction mixture was cooled to room temperature and diluted with cold water. The solids were collected by filtration and dried under reduced pressure. The solids were triturated with diethyl ether and pentane to afford titled compound (250 mg) as an off-white solid. LCMS 396.98 m/z (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 147291-66-5, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
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Synthetic Route of 550-89-0, These common heterocyclic compound, 550-89-0, name is Phenazine-1-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1: Synthesis of 1-amino-phenazineA solution of sodium methanolate (25% in MeOH, 24.6 ml, 107 mmol) in 100 ml MeOH was cooled to -78C and a solution of bromine (2.10 ml, 40.9 mmol) in 10.0 ml MeOH was added over a period of 2 min. Under further cooling the solution was first stirred 5 min followed by the addition of phenazine- 1-carboxamide (4.00 g, 17.9 mmol) in 200 ml dry methanol and 400 ml dry THF over a period of 1 h via dropping funnel. After the complete addition a clear orange solution was obtained that was warmed to room temperature and further stirred 2 h at 55C. Following the mixture was cooled down to room temperature and stirred further 72 h. After evaporating under reduced pressure the residue was dissolved in methanol (300 ml) and aqueous NaOH (40%, 150 ml) and refluxed for 4 h at 90C. Subsequently the solution was cooled down to 0C and set to pH 8.5 with concentrated HC1, obtain- ing a dark red suspension. After concentrating to about 200 ml under reduced pressure 500 ml water was added. The mixture was extracted three times with CHC13. The combined organic layers were dried over Na2S04 and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (n-hexane/ethyl acetate, 80:20 -> 75:25) obtaining 2.86 g (82%) of the title compound as dark red solid.

The synthetic route of 550-89-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG; ROCHE DIAGNOSTICS OPERATIONS, INC.; HEINDL, Dieter; NORTMEYER, Christine; GEBAUER, Peter; HUNT DU VALL, Stacy; BAUER-ESPINDOLA, Klaus Andreas; WO2015/158645; (2015); A1;,
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Reference of 68524-30-1, These common heterocyclic compound, 68524-30-1, name is 2-[(Diphenylmethyl)thio]acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: VO(acac)2 (2 mol %) and ligand 6 or 10 (3 mol %) were dissolved in CHCl3 (145 muL). The solution turned slightly green-brown after stirring for 60 min. 2-(Benzhydrylthio)acetamide (30 mg, 0.12 mmol) was added, followed by the addition of aqueous H2O2 (30%, 1.2 equiv) in one portion. The reaction mixture was stirred at room temperature for a certain time (see Table 5, entries 2-7). The product was directly purified by column chromatography on silica gel (EtOAc). The isolated enantiomerically-enriched (R)-modafinil was identified through comparison of 1H NMR spectra with literature data (see Ref. 19). The enantiomeric excess of the product was determined by chiral HPLC analysis (Daicel Chiralpak AS, flow 0.9 mL/min, Hex/i-PrOH 60:40, 25 C, 31 bar).

The synthetic route of 68524-30-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Stingl, Kerstin A.; Weiss, Katharina M.; Tsogoeva, Svetlana B.; Tetrahedron; vol. 68; 40; (2012); p. 8493 – 8501;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 147291-66-5 as follows. Computed Properties of C12H18N2O2

The oil was dissolved in 100 ml of THF, and 3.66 ml of DIPEA and then dropwise 2.60 g of benzyl isocyanate were added to the solution. The mixture was stirred at RT for 16 h, then under reflux for 6 h and then at RT for a further 16 h. It was concentrated and crystallized from 30 ml of ethyl acetate, and the resulting precipitate was filtered off with suction and dried; 4.90 g; ESI-MS [carbamic acid fragment+H+]=300.

According to the analysis of related databases, 147291-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott GmbH & Co. KG; US7105508; (2006); B1;,
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Adding a certain compound to certain chemical reactions, such as: 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 141449-85-6, Product Details of 141449-85-6

A solution of (4-Chloro-5-methyl-3-trifluoromethylpyrazol-1-yl) acetic acid (97 mg), triethylamine (0.2 mL) and compound 5 (76 mg) in DMF (2 mL) was stirred at 0 C and 1-propanephosphonic acid cyclic anhydride (0.55 mL, 50% in EtOAc) was added dropwise. The reaction mixture was stirred another 30 min at 0 C and directly purified by preparative HPLC to provide the title compound 6 as a pale yellow oild (146 mg, 93%). LCMS: Rf: 4.495 min, M+H+ : 459.

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Reference:
Patent; CHEMOCENTRYX, INC.; WO2005/84667; (2005); A1;,
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