Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 99733-18-3

General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL×2). The combined organic phase was washed with water (20 mL×3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.

According to the analysis of related databases, 99733-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Some common heterocyclic compound, 917342-29-1, name is tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate, molecular formula is C13H25NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate

The compound 20 (3.40 g, 13.97 mmol) was dissolved in dichloromethane (34 mL). To the solution was added 4 mol/L hydrochloric acid (dioxane solution, 34.9 mL, 140 mmol). The mixture was stirred at room temperature for 3 hours. To the mixture, methanol (5 mL) was added and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure to give a compound 21 as a crude product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 917342-29-1, its application will become more common.

Reference:
Patent; Shionogi & Co., Ltd.; TOBINAGA, Hiroyuki; MASUDA, Koji; KASUYA, Satoshi; INAGAKI, Masanao; YONEHARA, Mitsuhiro; MASUDA, Manami; (289 pag.)US2019/161501; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, A new synthetic method of this compound is introduced below., Quality Control of 4-(Trifluoromethyl)benzenesulfonamide

General procedure: All solid chemicals used were dried in vacuum over P2O5 overnight.The acid derivative and CDI were dissolved in dry THF underN2 atmosphere and the mixture was allowed to stir at 66-68 C for2 h. The sulfonamide and DBU dissolved in THF were added to thereaction mixture and stirring was continued at room temperature(4 h-overnight).Method B1: The solvent was removed in vacuo, water was addedand pH was adjusted to 2 by addition of 1 M HCl aq. The aqueousphase was extracted with EtOAc (2 40 ml), dried with MgSO4, filteredand evaporated in vacuo. For most of the compounds, a silicagel column was first run, followed by purification on aluminumoxide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Belfrage, Anna Karin; Abdurakhmanov, Eldar; Akerblom, Eva; Brandt, Peter; Oshalim, Anna; Gising, Johan; Skogh, Anna; Neyts, Johan; Danielson, U. Helena; Sandstroem, Anja; Bioorganic and Medicinal Chemistry; vol. 24; 12; (2016); p. 2603 – 2620;,
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Adding a certain compound to certain chemical reactions, such as: 97-35-8, name is 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97-35-8, Product Details of 97-35-8

EXAMPLE 12 Synthesis of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonyl-aminocarbonyl)naphthalene STR22 3-Amino-4-methoxydiethylaminosulfonylbenzene (15.6 g), N-methyl-2-pyrrolidone (86.1 g) and toluene (34.3 g) were dissolved at room temperature and the acid chloride (5.4 g) obtained in Example 6 was gradually added, and then the mixture was amidated at 90 C. for 24 hours. After the reaction solution was cooled to 25 C. and filtered, toluene was distilled off under reduced pressure. Then, the solution was crystallized by using methanol (350.1 g). The resultant product was filtered and then dried to obtain 8.9 g of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonylphenyl-aminocarbonyl)naphthalene as a cream powdered crystal (DSC analysis value: 245.0 C.). An infrared spectrum (KBr method) of this compound is shown in FIG. 12.

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Reference:
Patent; Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo; US5786523; (1998); A;,
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Reference of 39945-54-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39945-54-5, name is Benzyl (3-bromopropyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 7 3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamine The following is the preparation of a compound of Formula 3 in which R1 is methoxy, R2 is hydro and R9 is amino. A mixture of benzyl (3-bromopropyl)aminoformate (495.2 g, 1.82 mol), prepared as in Example 6, 1-(2-methoxyphenyl)piperazine hydrochloride (377.9 g, 1.65 mol) and potassium carbonate (456.8 g, 3.31 mol) in 3L of DMF was stirred at 80 to 81 C. for 3.5 hours. The mixture was allowed to cool to room temperature and then poured into 20L of water. The mixture was extracted with ethyl acetate (3*4L). The combined ethyl acetate extracts were washed with water (2*1L) and saturated aqueous sodium chloride (1*1L), dried (Na2 SO4) and treated with silica gel (200 g). The ethyl acetate was filtered and 11L of the filtrate was added slowly to 200 mL of 5.5N hydrochloric acid (2.75 mol) in ethanol at a rate such that the reaction temperature did not exceed 23 C. The mixture was aged at room temperature for 1 hour and filtered. The filtered residue was washed with ethyl acetate (3*500 mL), dried under a stream of air for 17 hours and then dried under reduced pressure at 60 C. to give benzyl 3-[4-(2-methoxyphenyl)piperazin-1-yl]propylaminoformate dihydrochloride (496 g, 1.09 mol), m.p. 174-176 C.

The synthetic route of Benzyl (3-bromopropyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5688795; (1997); A;,
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195986-74-4, name is 7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H7BrN2O2

To a solution of 7-bromo-3,4~dihydro-lH-benzo[e][l,4]diazepine-2,5-dione (1 equiv) in dry dioxan (0.1 M) were added bis(pinacolato)diboron (1.1 equiv), potassium acetate (3.5 equiv) and dppf (0.05 equiv). The reaction mixture was degassed with nitrogen for 20 minutes. PdCl2(dppf) (0.05 equiv) was added to the reaction mixture, which was degassed for a further 5 minutes. The reaction was heated to 120 C for 16 hours under nitrogen. The reaction mixture was partitioned between CH2CVMeOH and water. The aqueous phase was further extracted with CH2Cl2MeOH. The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The residue was sonicated in hexane/ CH2Cl2, filtered, sonicated in CH2Cl2 and filtered to yield the desired product.7-(4,4,5,5-Tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,4-dihydro-lH-benzo[e][l,4]diazepine-2,5- dione: (63 % yield, 85 % purity main impurity being the boronic acid 15 %) m/z (LC-MS, ESP): 303.4 [M+H]+ R/T = 3.08 min

The synthetic route of 195986-74-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2008/23161; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6292-59-7, name is 4-(tert-Butyl)benzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6292-59-7, Product Details of 6292-59-7

Process for conversion of compound (2) to (3) (stage 2)A mixture of DMSO (10 vol), potassium carbonate (1.2 eq), 4-tert-butyl phenyl sulfonamide (1 eq) and compound (2) (1 eq) was heated at 1200C for 10 hours. After completion of the reaction, water (25 vol) was added to the reaction mixture, the reaction mixture was acidified with a solution of tartaric acid (1.8 eq) in water (25 vol) to pH 3, and the precipitated solid was filtered under vacuum and dried under vacuum (lOmbar) at 500C for 2 hours. The product (compound (3)) was obtained as a light brown solid (molar yield = 100percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; WO2009/98517; (2009); A1;,
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Application of 2736-23-4,Some common heterocyclic compound, 2736-23-4, name is 2,4-Dichloro-5-sulfamoylbenzoic acid, molecular formula is C7H5Cl2NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of appropriate 2,4-dichloro-5-sulfamoylbenzoic acid (compound 1) or 2,4- dibromo-5-sulfamoylbenzoic acid (compound 2) (10.0 mmol), SOQ2 (2-3 eq), and 1 drop DMF in toluene (5 ml) was refluxed for 4 h. Excess SOCb and toluene were removed by distillation under reduced pressure, and the crude acid chloride was used directly in the next step.

The synthetic route of 2736-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VILNIUS UNIVERSITY; MATULIS, Daumantas; ?APKAUSKAIT?, Edita; ZAK?AUSKAS, Andrius; MORK?NAIT?, Vaida; (82 pag.)WO2017/17505; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 147291-66-5, name is tert-Butyl 3-aminobenzylcarbamate, A new synthetic method of this compound is introduced below., COA of Formula: C12H18N2O2

tert-butyl (3-amino-benzyl)-carbamate 9.35 g (76.49 mmol) 3-aminomethyl-phenylamine are dissolved in 200 ml dichloromethane and 100 ml of tetrahydrofuran, a solution of 17.03 g (78.02 mmol) Boc-anhydride in 200 ml dichloromethane is added dropwise. The mixture is stirred for 2.5 hours at ambient temperature, then evaporated down. The residue is precipitated as the hydrochloride. Yield: 17.48 g (88% of theoretical)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Brandl, Trixi; Maier, Udo; Hoenke, Christoph; Joergensen, Anne T.; Pautsch, Alexander; Breitfelder, Steffen; Grauert, Matthias; Hoffmann, Matthias; Scheuerer, Stefan; Erb, Klaus; Pieper, Michael; Pragst, Ingo; US2007/238746; (2007); A1;,
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Application of 28797-48-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28797-48-0, name is 11-(2-Chloroacetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 36 11-[[4-[2-[2-(Diethylamino)ethoxy]ethyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Prepared analogously to Example 1 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-[2-[2-(diethylamino)ethoxy]ethyl]piperidine (Bp0.009 mmHg 96-102 C.) in a yield of 46% of theory. Colourless crystals, m.p. 130-131 C. (acetonitrile).

The synthetic route of 11-(2-Chloroacetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dr. Karl Thomae, GmbH; US5175158; (1992); A;,
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