Tag: M.W=200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 114457-94-2, Name is (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid, SMILES is O=C(O)[C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2, in an article , author is Costil, Romain, once mentioned of 114457-94-2, Computed Properties of https://www.ambeed.com/products/114457-94-2.html.

We report the first desymmetrization of bisallylic amides by enantioselective bromocyclization with BINAP monoxide as a catalyst Depending upon the substitution pattern of the alkene moieties, densely functionalized, optically active oxazoline or dihydrooxazine compounds were obtained in a highly stereoselective manner. The remaining alkene moiety was subjected to various functional group manipulations to afford a diverse array of chiral molecules with multiple stereogenic centers.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is an experimental science, SDS of cas: 71-44-3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 71-44-3, Name is Spermine, molecular formula is C10H26N4, belongs to amides-buliding-blocks compound. In a document, author is Xie, Long -Yong.

Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology. In particular, Clk1 and -4 are overexpressed in several human tumors. Most of the potent Clk1 inhibitors reported in the literature are non-selective, mainly showing off-target activity towards Clk2, Dyrk1A and Dyrk1B. Herein, we present new 5-methoxybenzothiophene-2-carboxamide derivatives with unprecedented selectivity. In particular, the introduction of a 3,5-difluoro benzyl extension to the methylated amide led to the discovery of compound 10b (cell-free IC50 = 12.7 nM), which was four times more selective for Clk1 over Clk2 than the previously published flagship compound 1b. Moreover, 10b showed an improved growth inhibitory activity with T24 cells (GI(50) = 0.43 mu M). Furthermore, a new binding model in the ATP pocket of Clk1 was developed based on the structure-activity relationships derived from new rigidified analogues.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 71-44-3, in my other articles. SDS of cas: 71-44-3.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Reference of 138-41-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 138-41-0, Name is Carzenide, SMILES is C1=C(C=CC(=C1)[S](N)(=O)=O)C(O)=O, belongs to amides-buliding-blocks compound. In a article, author is do Couto, Rene Oliveira, introduce new discover of the category.

Tryptophan-conjugated graphene quantum dots (Trp-GQDs) were fabricated for the first time and loaded with curcumin (Cur) as a hydrophobic anticancer agent, to evaluate Cur loading capacity and release kinetics, as well as its cytotoxicity effect on human breast cancer cells. The GQDs were synthesized through a facile oxidation method, Trp was conjugated onto GQDs via amide bonds and Cur was loaded onto GQDs and Trp-GQDs by noncovalent interactions. TEM, FESEM, PL, UV-Vis, and FTIR analysis were used to study the nano-assemblies structural and spectral characterizations. The drug loading capacity increased by increasing the initial concentration of Cur, and by 23% after the conjugation of GQDs with Trp. A pH-sensitive release was also detected at pH 5.5 and 7.4. Moreover, the experimental release data of Cur from the two nano-assemblies at both pHs had the best compliance with the pseudo-second-order model. In-vitro cellular cytotoxicity on MCF-7 cells demonstrated the nontoxicity of the bare GQDs and Trp-GQDs nanocarriers. Considering the biocompatibility, traceability, high drug loading capacity, and pH-sensitivity of Trp-GQDs nanocarrier, it can be concluded that Cur/Trp-GQDs can be regarded as a promising candidate for drug delivery applications.

Reference of 138-41-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 138-41-0.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: https://www.ambeed.com/products/637-01-4.html, 637-01-4, Name is N1,N1,N4,N4-Tetramethylbenzene-1,4-diamine dihydrochloride, SMILES is CN(C)C1=CC=C(N(C)C)C=C1.[H]Cl.[H]Cl, belongs to amides-buliding-blocks compound. In a document, author is Lejay, Mathieu, introduce the new discover.

Hydrogen storage materials have been a subject of intensive research during the last 4 decades. Several developments have been achieved in regard of finding suitable materials as per the US-DOE targets. While the lightweight metal hydrides and complex hydrides meet the targeted hydrogen capacity, these possess difficulties of hard thermodynamics and sluggish kinetics of hydrogen sorption. A number of methods have been explored to tune the thermodynamic and kinetic properties of these materials. The thermodynamic constraints could be resolved using an intermediate step of alloying or by making reactive composites with other hydrogen storage materials, whereas the sluggish kinetics could be improved using several approaches such as downsizing and the use of catalysts. The catalyst addition reduces the activation barrier and enhances the sorption rate of hydrogen absorption/desorption. In this review, the catalytic modifications of lightweight hydrogen storage materials are reported and the mechanism towards the improvement is discussed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 637-01-4. HPLC of Formula: https://www.ambeed.com/products/637-01-4.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 19982-07-1, Name is N-(3,5-Dimethyladamantan-1-yl)acetamide, molecular formula is C14H23NO. In an article, author is Li, Jing,once mentioned of 19982-07-1, Recommanded Product: 19982-07-1.

Doxorubicin (DOX) is a leading cytostatic drug with many adverse effects in use. We are still looking for methods that will allow us to preserve the therapeutic effect against the tumor cells and reduce the toxicity to the normal cells. In our work, we obtained amide derivatives of DOX by reaction of the amino group with alpha-linolenic (LNA) and docosahexaenoic (DHA) acids (2, 3), as well as double-substituted derivatives via amide and ester linkages (4, 5). The structures of the compounds were confirmed by Proton Nuclear Magnetic Resonance (1H NMR), Carbon-13 Nuclear Magnetic Resonance (13C NMR), and High Resolution Mass Spectrometry (HRMS) analyses. For all compounds 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the cytotoxic effect on human cancer cell lines (SW480, SW620, and PC3) and Chinese hamster lung fibroblasts (V79) that were used as a control. The cytotoxic activity was established by calculation of the inhibitory concentration IC50. In addition, a cytotoxic capacity against tumor cells for tested compounds was expressed as a selectivity factor (selectivity index, SI). Lactate dehydrogenase (LDH) assay was performed for all compounds to assess the level of cell damage. To explain the basic mechanism of cell death induction the Annexin V-FITC/IP flow cytometry analysis was investigated. We found that all studied conjugates exhibit lower cytotoxicity but higher selectivity than DOX. Among the all derivatives, the conjugates formed by the amide and ester linkages (4, 5) were found to be more promising compared with conjugates (2, 3) formed only by the amide linkage. They show high cytotoxicity toward the tumor cell lines and moderate cytotoxicity towards the normal cell line.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is an experimental science, Name: (R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 86123-95-7, Name is (R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid, molecular formula is C9H17NO5, belongs to amides-buliding-blocks compound. In a document, author is Farag, Ahmed Karam.

The specific interactions between polyacrylamide brushes composed of polyacrylamide chains tethered to montmorillonite particles (Mt-g-PAm) and the individual components of immiscible ethylene-propylene-diene modified with sorbic acid (EPDM) and methyl vinyl silicone (MVQ) blends were studied. The effect of various lengths of PAm chains and their grafting density on montmorillonite (Mt) surface was investigated. It was determined that, due to interactions generated within the system through carboxyl and amide groups the brush particles were selectively located at the EPDM/MVQ interphase and in the EPDM phase. Furthermore, the longer PAm chains resulted in an increase of the glass transition of EPDM, unification of blend morphology, and the reduction of crystallinity of the MVQ phase. Therefore, precisely designed polymer brushes could be considered as novel functional compatibilizers, that provide a new tool for the future material designing.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 86123-95-7. Name: (R)-2-((tert-Butoxycarbonyl)amino)-3-methoxypropanoic acid.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 13734-41-3, Name is Boc-Val-OH, formurla is C10H19NO4. In a document, author is Yoritate, Makoto, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/13734-41-3.html.

The first heterogeneous gold(I)-catalyzed direct C(sp(2))-C(sp) bond functionalization of arylalkynes through a nitrogenation process to amides has been achieved by using an ordered mesoporous silica (MCM-41)-immobilized phosphine gold(I) complex [MCM-41-PPh3-AuCl] as catalyst and silver carbonate (Ag2CO3) as cocatalyst with trimethylsilyl azide (TMSN3) as a nitrogen source, yielding a variety of amides in moderate to excellent yields under mild conditions. This heterogeneous phosphine gold(I) complex shows the same turnover numbers as the homogeneous chloro(triphenylphosphine)gold(I) (Ph3PAuCl) and can easily be recovered by simple filtration of the reaction solution and recycled at least eight times without significant loss of activity, providing a novel, efficient, practical and economic method for the synthesis of amides from alkynes.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, SMILES is C1=CC(=CC=C1C(C)(C)C)[S](N)(=O)=O, in an article , author is Cao, Wenqi, once mentioned of 6292-59-7, Recommanded Product: 6292-59-7.

Despite hydrogen bonds widely existing in functional polymeric binders, the non-covalent interaction has not been investigated systematically. Owing to the abundant amide groups and easy access to hydrogen bonded assembly, poly (ethyl oxazoline) (PEtOx) is considered a suitable tool to explore the relationship between hydrogen bonds and the electrochemical performance of sulfur cathodes. By adding different amounts of proton-donating poly (acrylic acid) (PAA) into PEtOx, a series of hydrogen-bonded complexes can be obtained easily. The complexes as modified binders are then evaluated by electrochemical tests on the corresponding sulfur cathodes. The results suggest that the sulfur cathode based on the binder of PEtOx: PAA with the mass ratio of 4:1 (PP41) delivers a superior cycling stability to other ones. DSC and XRD tests confirm that the preferable electrochemical performance originates from the optimum hydrogen-bonding density, which balances the well-stretched polymeric chain and the mechanical strength of the cross-linked complexes. Benefiting from the abundant amide groups as well as the well-distributed polymer chain, the PP41-based sulfur cathode displays a more stable cycling performance than the PEtOx and PVdF-based one. (C) 2019 The Electrochemical Society.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Let’s face it, organic chemistry can seem difficult to learn, Name: Z-Pro-OH, Especially from a beginner’s point of view. Like 1148-11-4, Name is Z-Pro-OH, molecular formula is amides-buliding-blocks, belongs to amides-buliding-blocks compound. In a document, author is Li, Tao, introducing its new discovery.

With an aim to develop potent lead molecules as a novel class of reverse transcriptase (RT) inhibitors, we have synthesized amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-one derivatives. The compounds 9a and 9f exhibited IC50 values of 0.21113 +/- 0.013 mu M and 12.6804 +/- 0.062 mu M respectively from the in vitro human immunodeficiency virus type 1 (HIV-1) RT assay. None of the compounds showed toxicity towards peripheral blood mononuclear cells (PBMC). Structure-activity relationship (SAR) studies were performed for the synthesized compounds in order to estimate the effect of the substitution pattern on the RT inhibition potency. In silico docking studies revealed that two or more interactions are necessary for significant activity.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-(tert-Butyl)benzenesulfonamide, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6292-59-7, Name is 4-(tert-Butyl)benzenesulfonamide, molecular formula is C10H15NO2S. In an article, author is Kovalchik, Kevin A.,once mentioned of 6292-59-7.

The diaminoferrocene derivatives [Fe{(eta(5)-C5H4)NHR}(2)] (1H(2), a: R = SiMe(2)tBu, b: R = CMe(2)tBu, c: R = C6H3-2,6-iPr(2)) were converted into the lithium amides 1aLi(2) – 1cLi(2) by treatment with nBuLi. The reaction of these amides with AlI3 furnished 1aAlI – 1cAlI. The reduction of 1aAlI with KC8 afforded 1aAl-Al1a, which is a new stable dialumane(4) with exclusively tricoordinate Al atoms and only the second example so far of a tetraamino-substituted compound of this kind. 1bH(2), 1cH(2), 1aLi(2), [1c{Li(THF)(3)}(2)], [1aAlI(OEt2)], 1cAlI, 1aAl-Al1a center dot 1/2Et(2)O and 1aAl-Al1a center dot 1/2C(7)H(8) were structurally characterized by single-crystal X-ray diffraction.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics