Synthetic Route of 14719-21-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14719-21-2 as follows.
F1 (0.7 mmol, 247 mg) was added to a single-necked flask and 9.7 mg CuI and 20.3 mg Pd (PPh3) 4 (tetrakistriphenylphosphine) palladium were weighed into a reaction flask. The reaction flask was evacuated, purged with nitrogen and wrapped in aluminum foil , 2.3 ml DMF was added,Stirring to dissolve, adding 0.2ml TEA, weighing F2 (254mg, 1.7mmol) dissolved in DMF was added to the above reaction flask, stirred at room temperature, the reaction overnight.TLC plate monitoring, EA as developing solvent, Rf = 0.35 as the raw material F1, Rf = 0.32 for the product F3, two very close position.After the reaction was over, the solvent was evaporated to dryness under reduced pressure and the residue was directly purified by column chromatography. Elution with 20: 1 DCM: MeOH as eluant gave 214 mg, yield 61%.
According to the analysis of related databases, 14719-21-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Gong Bing; Shao Zhifeng; Zhao Xiaodong; Liu Yazhi; Li Xiaowei; Wu Xinyan; Wei Xiaofei; Tang Daonian; (99 pag.)CN104292117; (2016); B;,
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