Adding a certain compound to certain chemical reactions, such as: 40545-33-3, name is 2-Amino-5-methylbenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40545-33-3, SDS of cas: 40545-33-3
General procedure: To a cold (0-5 C) stirred suspension of aminobenzamides 2a-g (0.016 mol) in pyridine (13 ml), 0.016 mol of the appropriate cinnamoyl chloride 3a-e, 3-phenylpropioloyl chloride 3f-k and 3-phenylpropanoyl chloride 3l-o was added over 30 min. After addition was complete, the solution was stirred for 24 h and then poured onto crushed ice. The precipitate was removed by filtration, washed with water, and crystallized from the appropriate solvent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-5-methylbenzamide, and friends who are interested can also refer to it.
Reference:
Article; Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 427 – 435;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics