In an article, author is Martinez, Roberto, once mentioned the application of 144978-35-8, Recommanded Product: 1-Boc-D-Pyroglutamic acid ethyl ester, Name is 1-Boc-D-Pyroglutamic acid ethyl ester, molecular formula is C12H19NO5, molecular weight is 257.283, MDL number is MFCD09261329, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
In this study, new tri-amides 5a-1 have been synthesized via a one-pot four-component Ugi reaction between repaglinide, aniline derivatives, aldehyde derivatives, and cyclohexyl isocyanide in good yields. These compounds were evaluated against yeast alpha-glucosidase. Obtained in vitro alpha-glucosidase results demonstrated that all the synthesized compounds 5a-1 were more potent than standard inhibitor acarbose. Among them, the most potent compounds were compounds 5j, 5k, and 5h. The kinetic analysis of the most potent compound 5j revealed that this compound is a competitive inhibitor for alpha-glucosidase (K-i = 24 mu M). Furthermore, docking study of the most potent compounds was also performed in the alpha-glucosidase active site to find interaction modes and binding energies of these compounds. (C) 2020 Elsevier B.V. All rights reserved.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics