Category: amides-buliding-blocks

Seidelmann, O. published the artcileCyclic voltammetric studies on N,N-disubstituted N’-ferrocenoylthioureas and their transition metal complexes, Recommanded Product: Morpholine-4-carbothioamide, the publication is Polyhedron (1998), 17(10), 1601-1610, database is CAplus.

The Fe(II)/Fe(III) redox potentials of N,N-disubstituted N’-ferrocenoylthioureas and the resp. ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids are shifted cathodically by complexation of Ni(II), Cu(II), Co(III), Mn(II), Pt(II) and Pd(II). The extent of the shift is more pronounced in the latter ligand class and reaches values up to -0.32 V. The N,N-disubstituted N’-ferrocenoylthioureas exhibit two redox processes in dichloromethane. A mechanistic scheme is proposed. Ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids decompose after oxidation in dichloromethane. In contrast, complexes of both ligand types contain quasireversibly oxidizable ferrocene subunits.

Polyhedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C17H20ClN3, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gorska, Katarzyna published the artcileLigand dimerization programmed by hybridization to study multimeric ligand-receptor interactions, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(41), 7742-7744, database is CAplus and MEDLINE.

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Name: 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Remen, Lubos published the artcilePreparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers, Category: amides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8398-8411, database is CAplus and MEDLINE.

Aryldihydropyrazolecarboxamides such as I were prepared as brain-penetrating T-type calcium channel blockers for potential use as antiepileptic agents; their inhibition of T-type calcium channels over related calcium channels responsible for potential cardiovascular side effects was determined I was advanced to in vivo studies, where it demonstrated efficacy in the WAG/Rij rat model of generalized nonconvulsive, absence-like epilepsy. I was not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rodents.

Journal of Medicinal Chemistry published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Naik, Kuverji Gosai published the artcileCondensation of cyanoacetic ester with some aryl- and alkyl-amines. Preparation of some aryl- and alkyl-substituted cyano-acetamides, Formula: C5H8N2O, the publication is Quarterly Journal of the Indian Chemical Society (1927), 547-51, database is CAplus.

Cyano- aceto-toluidide, m. 125°, m-toluidide, m. 132°, α-naphthylamide, m. 175°, β-naphthylamide, m. 174°, vic-m-xylidide, m. 107°, methylamide, m. 101° and ethylamide, m. 74°, are prepared for the first time. The methods of preparation vary with the basic strength of the amines. In the preparation of the substituted amides of the aromatic acids, Whiteley’s method, as modified by Naik (C. A. 15, 2072) was used. Cyanoacetanilide, m. 198-9° is prepared by refluxing CNCH₂CO₂Et with redistilled NH₂ at 160-70° for 6 hrs. p-Toluidide, similarly prepared, substituting p-MeC₆H₄NH₂ for PhNH₂, m. 180°. Benzylamide, m. 120°.

Quarterly Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shukla, J. S. published the artcileSynthesis of some enaminonitriles, HPLC of Formula: 15029-36-4, the publication is Journal of the Indian Chemical Society (1978), 55(3), 281-3, database is CAplus.

Reaction of EtO₂CCH₂CN with RNH₂ gave RNHCOCH₂CN (I; R = Me, Et, PhCH₂, naphthyl, etc.). Treatment of I by CH₂:CHCN gave RNHCOC(CN)(CH₂CH₂CN)₂ (same R). The Thorpe-Ziegler cyclization of the latter gave the title compounds II.

Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C18H28B2O4, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shukla, J. S. published the artcileSome newer cyanoethylated alkyl- and aryl-substituted cyanoacetamides as insecticides. Part III, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Journal of the Indian Chemical Society (1976), 53(2), 196-7, database is CAplus.

Cyanoacetamides NCC(CH2CH2CN)2CONHR (I, R = C1-C4 alkyl, PhCH2, 2-MeC6H4, 1- or 2- naphthyl) were prepared by reaction of NCCH2CO2Et with RNH2, followed by cyanoethylation with CH2CHCN in dioxane. Insecticidal test data were given for I and several other cyanoethylated amides.

Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H15NO6S, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bai, Shao-Tao published the artcileHydrogen Bond Directed ortho-Selective C-H Borylation of Secondary Aromatic Amides, Related Products of amides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2019), 58(37), 13039-13043, database is CAplus and MEDLINE.

Reported is an Ir catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by H-bond interactions. The BAIPy-Ir catalyst forms three H bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.

Angewandte Chemie, International Edition published new progress about 1197171-76-8. 1197171-76-8 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, and the molecular formula is C14H20BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kamble, Sumit B. published the artcileA single pot organocatalytic diastereoselective synthesis of fluorescent ring fused 2-pyridone decalines via a domino Knoevenagel/Michael/hydro-lactamisation sequence, Formula: C5H8N2O, the publication is Organic Chemistry Frontiers (2021), 8(18), 5032-5039, database is CAplus.

Multifunctional ring fused octahydro 3-CN-2-pyridone I (R = Ph, thiophen-2-yl, 1,3-benzodioxol-5-yl, etc.; R¹ = H, Me, Et) decaline motifs are constructed by a single pot multicomponent, diastereoselective, organocatalytic domino approach. Three consecutive catalytic reaction sequences are presented, wherein L-proline plays a catalytic dual role for Knoevenagel condensation and Michael addition co-operatively with PhCOOH, followed by annulation by hydro-lactamisation. Compounds containing bromine, chlorine, methoxy and methylenedioxy groups showed aggregation-induced fluorescence under long-range UV exposure. The present method is a green synthetic strategy with the following features: high diastereoselectivity (dr > 20), catalytic activity, high yields, cost-effective nature, a simple, mild, and operationally scalable process, and broad substrate scope.

Organic Chemistry Frontiers published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jing, Zhi-Fei published the artcileInhibition of miR-34a-5p can rescue disruption of the p53-DAPK axis to suppress progression of clear cell renal cell carcinoma, Quality Control of 380315-80-0, the publication is Molecular Oncology (2019), 13(10), 2079-2097, database is CAplus and MEDLINE.

DAPK, a transcriptional target of the p53 protein, has long been characterized as a tumor suppressor that acts as a neg. regulator in multiple cellular processes. However, increasing studies have suggested that the role of DAPK may vary depending on cell type and cellular context. Thus far, the expression and function of DAPK in clear cell renal cell carcinoma (ccRCC) remain ambiguous. Since ccRCC behaves in an atypical way with respect to p53, whether the p53-DAPK axis functions normally in ccRCC is also an intriguing question. Here, tissue specimens from 61 ccRCC patients were examined for DAPK expression. Functional studies regarding apoptosis, growth, and migration were used to determine the role of DAPK in renal cancer cells. The validity of the p53-DAPK axis in ccRCC was also determined Our study identified DAPK as a neg. regulator of ccRCC, and its expression was reduced in certain subgroups. However, the p53-DAPK axis was disrupted due to upregulation of miR-34a-5p under stressed conditions. miR-34a-5p was identified as a novel repressor of DAPK acting downstream of p53. Inhibition of miR-34a-5p can correct the p53-DAPK axis disruption by upregulating DAPK protein and may have potential to be used as a therapeutic target to improve outcomes for ccRCC patients.

Molecular Oncology published new progress about 380315-80-0. 380315-80-0 belongs to amides-buliding-blocks, auxiliary class Apoptosis,p53, name is N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide, and the molecular formula is C20H23N3O2S, Quality Control of 380315-80-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathunuru, Ramadas published the artcileFacile synthesis of 4H-naphtho[2,3-e] derivatives of 1,3-thiazines and 1,3-selenazines and naphtho[2′,3′:4,5] derivatives of selenolo[2,3-b]pyridines and thieno[2,3-b]pyridines via 2,3- didehydronaphthalene, Product Details of C5H10N2OS, the publication is ARKIVOC (Gainesville, FL, United States) (2004), 51-60, database is CAplus.

Thiaazadienes (2a–e), selenoazadienes (6a–f), Barton selenium esters (8a–e) and Barton sulfur esters (10a–e) react with 2,3-didehydronaphthalene (4) generated from (phenyl)[(3-trimethylsilyl)-2-naphthyl]iodonium triflate (3) at 0°C to give 4H-naphtho[2,3-e]-1,3-thiazines (5a–e), 4H-naphtho[2,3-e]-1,3-selenazines (7a–f), naphtho[2′,3′:4,5]selenolo[2,3-b]pyridines (9a–e) and naphtho[2′,3′:4,5]thieno[2,3-b]pyridines (11a–d). The x-ray and mol. structure of 5e and 7b are reported.

ARKIVOC (Gainesville, FL, United States) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics