Category: amides-buliding-blocks

Kumar, T. N. V. Ganesh published the artcileStudy of dolutegravir degradation and spectroscopic identification of products by LCMS, 1H and 13C NMR Techniques, Safety of N-Methylformamide, the main research area is dolutegravir degradation product spectroscopy NMR LC MS.

Stability study for dolutegravir bulk drug was performed and the degradation products formed were identified by chromatog. (HPLC, LCMS) and spectroscopy (ESI-MS, FTIR, 1H and 13C NMR) techniques. Degradation of the drug in acidic and peroxide environment yielded one common major degradant f ((2,4-difluorophenyl) methanamine) with a mass peak at m/z = 182.44. In addition to this, five more minor degradation products (a, b, c, d and e) were formed. The structure interpretation showed that the drug degraded to its synthetic precursor and no extra structures were formed. Hence, it was suggested that drug dolutegravir should be kept away from acidic and oxygen rich conditions.

Pharmaceutical Chemistry Journal published new progress about Decomposition. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Langone, Deanna published the artcileImpurity profiling of methamphetamine synthesised from α-phenylacetoacetonitrile (APAAN), Safety of N-Methylformamide, the main research area is phenylacetoacetonitrile methamphetamine impurity profiling; APAAN; impurity profiling; methamphetamine.

The rise in popularity of ′designer′ precursor compounds for the synthesis of amphetamine-type stimulants poses a significant challenge to law enforcement agencies. One such precursor is α-phenylacetoacetonitrile (APAAN). APAAN emerged in Europe in 2010 and quickly became one of the most popular precursors for amphetamine synthesis in that region. Previous literature has identified four APAAN-specific impurities formed in the synthesis of amphetamine; however, there is currently no research on the use of APAAN in the synthesis of methamphetamine, which is more likely to be employed in a non-European market. In this study methamphetamine was synthesized via three common clandestine methods: the Leuckart method and two reductive amination methods. We report the identification of five new impurities and two previously identified impurities characteristic for the use of APAAN in the synthesis of methamphetamine. The newly identified impurities were characterised by MS and NMR and determined to be (E)-3-(methylamino)-2-phenylbut-2-enenitrile, 3-(methylamino)-2-phenylbutanenitrile, 3-methyl-2,4-diphenylpentanedinitrile, 2-phenylbutyronitrile and 3-hydroxy-2-phenylbutanenitrile.

Drug Testing and Analysis published new progress about Diastereomers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Baba, Mariko published the artcileCloning of the cytochrome P450 enzyme from Perilla frutescens involved in nothoapiole biosynthesis, Application In Synthesis of 123-39-7, the main research area is Perilla nothoapiole cytochrome P450; Biosynthetic pathway; Cytochrome P450; Molecular cloning; Perilla; Phenylpropanoid; Volatile compound.

Phenylpropanoid volatile components are found in various plants and are useful in medicines, health foods, and fragrances. While the pharmacol. actions and toxicities of these compounds have been investigated, there are few reports of the cloning of genes that encode biosynthetic enzymes involved in substituent formation at diverse positions and numbers Previously, using the expressed sequence tag (EST) libraries of pure perilla strains that have been maintained for over 30 years for their oil type, we characterized the P 450 enzyme that produces an intermediate for dillapiole by adding a hydroxy group to myristicin. In this study, we selected a P 450 enzyme involved in nothoapiole biosynthesis from the EST library. Heterologous expression of this enzyme in yeast showed that it is a hydroxylase that synthesizes an intermediate to produce nothoapiole from apiole and dillapiole. The enzyme has high amino acid sequence similarity with a previously cloned enzyme and is categorized into the CYP71D subfamily. Furthermore, we investigated the presence or absence of essential oil components and intermediates believed to be involved in nothoapiole biosynthesis by component anal. of perilla essential oil using GC-MS to help elucidate the biosynthetic pathway of nothoapiole. Only a small number of plant species contain nothoapiole as their principal component and thus few studies have reported the biosynthetic genes involved or the drug efficacy and toxicity of nothoapiole. The present study will aid in understanding the biosynthesis of phenylpropanoid volatile compounds, thereby contributing to further research on potentially useful compounds such as nothoapiole.

Journal of Natural Medicines published new progress about Drug toxicity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Altomare, C. published the artcileLipophilicity measurements of benzenesulfonamide inhibitors of carbonic anhydrase by reversed-phase HPLC, Computed Properties of 35203-88-4, the main research area is lipophilicity benzenesulfonamide HPLC; carbonic anhydrase inhibitor benzenesulfonamide QSAR.

The lipophilicity of 33 meta and para substituted benzenesulfonamides was studied by reversed-phase HPLC using MeOH-H2O or MeCO-H2O as the mobile phases and μ Bondapak C18 as the stationary phase. A linear relation between the capacity factor (log k’) and the volume fraction of the organic modifier (θ) was established for each solute. The extrapolation of the retention to φ = 0 (0% of organic modifier) 0% organic modifier) permitted the elimination of any selective and specific effects of organic modifier, to calculate log kw and finally to derive τw for each substituent. The Hansch’s π hydrophobic parameter was linearly correlated to τw (r = 0.953), but no improvement in the correlation equation was observed when τw values obtained by adding silanol masking amines to the mobile phase were used. By introducing an indicator variable which takes into account the possibility of the substituent to make hydrogen bonding, a slight but significant improvement was instead observed The replacement of π with τw in the regression equation obtained in a recent QSAR study on carbonic anhydrase inhibition by benzenesulfonamide gives rise to a correlation equation with comparable statistical significance.

International Journal of Pharmaceutics published new progress about Lipophilicity. 35203-88-4 belongs to class amides-buliding-blocks, name is 3-Acetylbenzenesulfonamide, and the molecular formula is C8H9NO3S, Computed Properties of 35203-88-4.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Matsunaga, Hiroki published the artcileThermal behavior of ammonium dinitramide and amine nitrate mixtures, Product Details of C2H5NO, the main research area is ammonium dinitramide amine nitrate thermal decomposition review.

This paper focuses on the thermal behavior of mixtures of ammonium dinitramide (ADN) and amine nitrates. Because some mixtures of ADN and amine nitrate exhibit low m.ps. and high-energy content, they represent potential liquid propellants for spacecraft. This study focused on the melting behavior and thermal-decomposition mechanisms in the condensed phase of ADN/amine nitrate mixtures during heating. We measured the m.p. and exothermal behavior during constant-rate heating using differential scanning calorimetry and performed thermogravimetry-DTA-mass spectrometry (TG-DTA-MS) to analyze the thermal behavior and evolved gases of ADN/amine nitrate mixtures during simultaneous heating to investigate their reaction mechanisms. Results showed that the m.p. of ADN was significantly lowered upon the addition of amine nitrate with relatively low mol. volume and low m.p. TG-DTA-MS results showed that the onset temperature of the thermal decomposition of ADN/amine nitrates was similar to that of pure ADN. Furthermore, during thermal decomposition in the condensed phase, ADN produced highly acidic products that promoted exothermic reactions, and we observed the nitration and nitrosation of amines from the dissociation of amine nitrates.

Journal of Thermal Analysis and Calorimetry published new progress about Melting point. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fischer, Rachel published the artcileAbraham model correlations for solute transfer into benzyl alcohol from both water and the gas phase, COA of Formula: C2H5NO, the main research area is organic compound solubility benzyl alcoho Abraham model.

Exptl. solubilities have been determined for anthracene, benzil, 2-chloroanthraquinone, 9-fluorenone, 2-hydroxybenzoic acid, 2-methoxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, phenothiazine, pyrene, and thioxanthen-9-one dissolved in benzyl alc. at 298.15 K. The measured solubility data, combined with previously published activity coefficient and solubility data, are used to determine Abraham model correlations for solute transfer to benzyl alc. from both water and from the gas phase. The derived Abraham model correlations were found to back-calculate the exptl. partition coefficients and solubility ratios to within 0.14 log units (or less).

Physics and Chemistry of Liquids published new progress about Melting point. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fu, Yong published the artcilePhotocatalytic degradation of acetochlor by α-Fe2O3 nanoparticles with different morphologies in aqueous solution system, Application of N-Methylformamide, the main research area is iron oxide nanoparticle acetochlor photocatalytic degradation.

Photocatalytic degradation technol. is an important and promising method for complete elimination of toxic organics In this study, the photocatalytic degradation of acetochlor using α-Fe2O3 nanoparticles under H2O2/UV system was studied with UV-Vis spectrophotometer and GC-MS. The degradation rate was investigated on the effects of α-Fe2O3 morphol. and dosage, initial acetochlor concentration, solution pH, and H2O2 dosage. The results showed that photocatalytic degradation efficiency could reach 91% by α-Fe2O3 with 200 mg/L hollow morphol. at an initial acetochlor concentration, pH value, and H2O2 dosage of 50 mg/L, 7 and 40 μL, resp. The photocatalytic reaction mechanism and degradation process of acetochlor by α-Fe2O3 were investigated and the degradation pathway of acetochlor was proposed. The oxidative attack involves N-C bond connecting the aromatic ring with side chain, the nitrogen-containing side chain, chlorinated aliphatic to produce 1-methyl-3-ving-benzene, allyl-methyl-amine and 1-chloro-2-ethoxy-ethane. These intermediate products could be further oxidized to NO-3, CO2 and H2O. These findings provide new insights for the photocatalytic degradation of organic pollutants in the using α-Fe2O3 nanoparticles to achieve pollutant degradation

Optik (Munich, Germany) published new progress about Nanoparticles. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bukenov, Bauyrzhan published the artcileQuantification of transformation products of rocket fuel unsymmetrical dimethylhydrazine in air using solid-phase microextraction, Name: N-Methylformamide, the main research area is transformation product rocket fuel unsym dimethylhydrazine air; solid phase microextraction; air sampling; solid-phase microextraction; transformation products; unsymmetrical dimethylhydrazines.

Quantification of unsym. dimethylhydrazine transformation products in ambient air is important for assessing the environmental impact of heavy rocket launches. There are little data of such analyses, which is mainly caused by the low number of analytes covered by the available anal. methods and their complexity. A simple and cost-efficient method for accurate simultaneous determination of seven unsym. dimethylhydrazine transformation products in air using solid-phase microextraction followed by gas chromatog.-mass spectrometry was developed. The method was optimized for air sampling and solid-phase microextraction from 20-mL vials, which allows full automation of anal. The extraction for 5 min by Carboxen/polydimethylsiloxane fiber from amber vials and desorption for 3 min provided the greatest analytes’ responses, lowest relative standard deviations, linear calibration (R2 ≥ 0.99), and limits of detection from 0.12 to 0.5μg/m3. Samples with concentrations 500μg/m3 can be stored at 21 ± 1° without substantial losses (1-11%) for up to 24 h, while air samples with concentrations 10 and 50μg/m3 stored for up to 24 h can be used for accurate quantification of only two and four out of seven analytes, resp. The developed method was successfully tested for the anal. of air above real soil samples contaminated with unsym. dimethylhydrazine rocket fuel.

Journal of Separation Science published new progress about Air analysis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mayhoub, Abdelrahman S. published the artcileOptimizing thiadiazole analogues of resveratrol versus three chemopreventive targets, Synthetic Route of 1208077-46-6, the main research area is resveratrol thiadiazole analog preparation antitumor aromatase NFkappaB QR1.

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biol. targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).

Bioorganic & Medicinal Chemistry published new progress about Antioxidants. 1208077-46-6 belongs to class amides-buliding-blocks, name is 4-Butylthiobenzamide, and the molecular formula is C11H15NS, Synthetic Route of 1208077-46-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Qigang published the artcileCopper-Catalyzed Enantioselective Ring-Opening of Cyclic Diaryliodoniums and O-Alkylhydroxylamines, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is cyclic diaryliodonium alkylhydroxylamine copper catalyst enantioselective ring opening atropisomer; hydroxyamino iodobiaryl stereoselective preparation.

A preparation of 2-hydroxyamino-2′-iodobiaryls via the Cu-catalyzed enantioselective ring-opening reaction of cyclic diaryliodonium salts with O-alkylhydroxylamines is reported. 3,5-Di(tert-butyl)phenyl bis(oxazoline) was found to be the optimal ligand, and up to 99% ee values were achieved. The use of CaO as the base dramatically improved the yields and inhibited the side reactions. Finally, synthetic applications of these hydroxylamines were briefly demonstrated.

Organic Letters published new progress about Atropisomers. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics