Category: amides-buliding-blocks

Prabsangob, Nopparat published the artcileEffect of tea catechin derivatives on stability of soybean oil/tea seed oil blend and oxidative stability of fried fish crackers during storage, Application of N-Methylformamide, the main research area is soybean seed oil fried fish cracker catechin oxidative stability; (−)-Epicatechin; (−)-Epigallocatechin gallate; Deep frying; Fish crackers; Lipid oxidation; Soybean oil; Tea seed oil.

Effect of (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin (EC) at different concentrations (100-300 ppm) on frying stability of soybean oil blended with tea seed oil was studied. Thermal stability of the blended oil increased with the addition of EGCG and EC, especially with increasing concentrations Frying induced degradation of tocopherols and phenolics of oils, particularly tocopherols. Incorporation of catechin derivatives could retard tocopherol decomposition and formation of polar materials. The highest frying stability was found for the oil added with EC at 300 ppm. When the oil added with EC (300 ppm) was used to prepare fish crackers, lowered lipid oxidation of the resulting crackers than those prepared using the control oil was noted throughout 12 wk of storage. EC could be effectively used as natural antioxidant in frying oil with carry through effect to enhance oxidation stability of the fried foods during a storage.

Food Science and Biotechnology published new progress about Autoxidation. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Carbonell-Hermida, Paloma published the artcileNecessity of imposing total miscibility for certain binary pairs in LLE data correlations, Recommanded Product: N-Methylformamide, the main research area is certain binary pair LLE data correlation total miscibility.

Liquid-liquid equilibrium (LLE) data correlation of multicomponent mixtures is frequently carried out without using any procedure to ensure that the model parameters obtained for the totally miscible binary mixtures are consistent with such behavior (i.e. they do not lead to two liquid phases in equilibrium). In other words, the behavior of the model beyond the LLE region fitted (exptl. tie-lines) is not usually considered in LLE correlations. It seems to be wrongly assumed that the mere absence of tie-lines data in totally miscible regions should guarantee that the parameters resulting from the LLE correlation lead to total miscibility in such homogeneous regions. We have checked that for the correlation of certain type 1 ternary systems (Treybal classification) a high probability exists of obtaining inconsistent model parameters, which lead to type 2 instead type 1 ternary behavior, unless specific restrictions for such parameters are imposed during the correlation. Com. tools to carry out this type of data fitting, which are frequently included in process simulation packages such as Aspen Plus, do not include the possibility of applying such restrictions and consequently they could provide this type of misleading correlation results with serious consequences in equipment design. In the present paper, LLE data correlation for certain type 1 ternary systems has been carried out using Aspen Plus resulting in inconsistent type 2 results. These same systems have been satisfactorily correlated using our own correlation tools including restrictions to ensure the required miscibility behavior, and thus obtaining consistent parameters. A similar problem could occur in the correlation of the less frequent island (or zero) type ternary systems. Some examples are also presented for such type of systems.

Fluid Phase Equilibria published new progress about Binary stars. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gundersen, Snefrid published the artcileThe molecular structure, conformation, potential to internal rotation and force field of 2,2-difluoroacetamide as studied by gas electron diffraction and quantum-chemical calculations, Application In Synthesis of 359-38-6, the main research area is difluoroacetamide mol structure conformation potential function DFT MP2 HF.

CHF2CONH2 was studied by electron diffraction (ED), ab initio HF, MP2 and d. functional theory calculations using a 6-311++G** basis set. The calculations give 1 conformation where 1 of the C-F bonds is almost orthogonal to the C-C-O-N skeleton plane and a planar NH2 group except for MP2, which predicts a slightly pyramidal NH2 group. The mol. force field was determined, and the fundamental frequencies were assigned and compared with the limited spectroscopic data available for this mol. The refined structural parameters were determined using constrained ED, i.e., ab initio results are included as constraints in the anal. Uncertainties are 1 standard deviation from least-squares refinement using a diagonal weight matrix and inclusion of the uncertainty in the electron wavelength. The structural parameters are compared with those of related amides. The barrier height at the syn conformation, V0, and the min. of the potential-energy function, φmin, are determined as 2.8(5) kJ mol-1 and 35(1)°, resp., which agree with theor. calculations The barrier height at the anti conformation, V180, was fixed to its calculated value of 20.3 kJ mol-1.

Journal of Molecular Structure published new progress about Conformation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application In Synthesis of 359-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gundersena, Snefrid published the artcileThe molecular structure, conformation, potential to internal rotation and force field of 2,2-difluoroacetamide as studied by gas electron diffraction and quantum-chemical calculations, Category: amides-buliding-blocks, the main research area is difluoroacetamide mol structure conformation potential function DFT MP2 HF.

CHF2CONH2 was studied by electron diffraction (ED), ab initio HF, MP2 and d. functional theory calculations using a 6-311++G** basis set. The calculations give 1 conformation where 1 of the C-F bonds is almost orthogonal to the C-C-O-N skeleton plane and a planar NH2 group except for MP2, which predicts a slightly pyramidal NH2 group. The mol. force field was determined, and the fundamental frequencies were assigned and compared with the limited spectroscopic data available for this mol. The refined structural parameters were determined using constrained ED, i.e., ab initio results are included as constraints in the anal. Uncertainties are 1 standard deviation from least-squares refinement using a diagonal weight matrix and inclusion of the uncertainty in the electron wavelength. The structural parameters are compared with those of related amides. The barrier height at the syn conformation, V0, and the min. of the potential-energy function, φmin, are determined as 2.8(5) kJ mol-1 and 35(1)°, resp., which agree with theor. calculations The barrier height at the anti conformation, V180, was fixed to its calculated value of 20.3 kJ mol-1.

Journal of Molecular Structure published new progress about Conformation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lee, S. K. published the artcileTemperature dependence of the binding of methyl orange by crosslinked poly(4-vinylpyridine), Formula: C10H16N2O2, the main research area is vinylpyridine polymer binding methyl orange; crosslinking vinylpyridine polymer dye binding.

The title polymers with different degrees of crosslinking were prepared by radical copolymerization of 4-vinylpyridine with 3-20% N,N’-tetramethylenebisacrylamide. The binding abilities of these crosslinked polymers with methyl orange were investigated at various temperatures in a buffer solution of pH 7. The first binding constant (K1) and thermodn. parameters were evaluated from the equilibrium amounts of binding. K1 showed bell-shaped curves when plotted against both the binding temperature and the degree of crosslinking. Lower temperature and higher degree of crosslinking at maximum binding in these bell-shaped curves were observed for this binding system when compared with those in a system using N,N’-methylenebisacrylamide as crosslinker. The values of the enthalpy and entropy change increased on increasing the degree of crosslinking and decreasing the binding temperature, whereas the absolute magnitude of the free-energy change was not increased. These results could be accounted for in terms of the temperature dependence of the hole size of the crosslinked polymers in addition to the hydrophobic interactions in the binding process.

Polymer published new progress about Crosslinking. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Formula: C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Woronick, Charles L. published the artcileSpectrophotofluorometric determination of the dissociation constants of amides from the enzyme-reduced coenzyme complex of liver alcohol dehydrogenase(ADH), Product Details of C2H3F2NO, the main research area is .

cf. ibid. 15(10), 2062(1961). A mixture of ADH and reduced diphosphopyridine nucleotide (DPNH) in solution, which contains a fluorescent ADH-DPNH complex, was titrated with solutions of amides while the fluorescence at 410 mμ was measured. Dissociation constants were obtained by plotting the reciprocal of the change in fluorescence intensity vs. the reciprocal of the amide concentration (method of Winer and Theorell, CA 56, 9102g). Values of KER.I. are tabulated for 17 amides (E = enzyme, R = DPNH, I = inhibitor (amide)). These agree well with the Michaelis constants obtained previously. The values are also plotted according to the Taft ρ*σ* equation and the correlations are discussed.

Acta Chemica Scandinavica published new progress about Dissociation. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Product Details of C2H3F2NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Yao-Te published the artcileResolved specific dissociation channel of a core-excited peptide model molecule, Related Products of amides-buliding-blocks, the main research area is methyl formamide dissociation mechansim branching ratio.

A core-excited peptide model, N-methylformamide, and its isotopically substituted species were used to resolve the channels of specific dissociation The variation of each product branching ratio with photon energy from three isotopically substituted mols. was measured. From the branching ratios of the products with varied ratios of mass to charge, the variation of the branching ratio of each dissociation channel was resolved. The obvious specific reaction mechanism dominantly involves only the dissociation channel that involves breaking the peptide bond and eliminating two hydrogen atoms to form CNH2+. An element-specific dissociation was observed on breaking a C=O bond.

Chemical Physics Letters published new progress about Dissociation. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Margiotta, Enrico published the artcileHalogen Bonds in Ligand-Protein Systems: Molecular Orbital Theory for Drug Design, Quality Control of 123-39-7, the main research area is drug design MO ligand protein halogen bond modeling.

Halogen bonds are highly important in medicinal chem. as halogenation of drugs, generally, improves both selectivity and efficacy toward protein active sites. However, accurate modeling of halogen bond interactions remains a challenge, since a thorough theor. investigation of the bonding mechanism, focusing on the realistic complexity of drug-receptor systems, is lacking. Our systematic quantum-chem. study on ligand/peptide-like systems reveals that halogen bonding is driven by the same bonding interactions as hydrogen bonding. Besides the electrostatic and the dispersion interactions, our bonding analyses, based on quant. Kohn-Sham MO theory together with energy decomposition anal., reveal that donor-acceptor interactions and steric repulsion between the occupied orbitals of the halogenated ligand and the protein need to be considered more carefully within the drug design process.

Journal of Chemical Information and Modeling published new progress about Binding energy. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Brownsey, Duncan K. published the artcileIdentification of ligand linkage vectors for the development of p300/CBP degraders, HPLC of Formula: 343338-28-3, the main research area is protein CBP degrader development ligand linkage vector.

To develop new degrader mols. from an existing protein ligand a linkage vector must be identified and then joined with a suitable E3 ligase without disrupting binding to the resp. targets. This is typically achieved through empirically evaluating the degradation efficacy of a series of synthetic degraders. Our strategy for determining optimal linkage sites utilizes biotinylated protein ligands, linked via potential conjugation sites of an inhibitor to confirm whether target protein is maintained after forming a conjugate. This method provides low-cost, qual. evidence that the addition of a linker moiety at a specific position can be tolerated, guiding further optimization. We demonstrate the application of this method through the exploration of linkage vectors on A-485, a known ligand of p300/CBP, and found a conjugation site through a urea moiety. Pomalidomide was then conjugated through this site with several different linkers and cell viability and degradation were assessed for this library using a myeloma cell line, MM1. S. Compound 18i, with a PEG4 linker, was found to be the most effective p300 degrader and linker length greater than 10 atoms afforded enhanced degradation

RSC Medicinal Chemistry published new progress about Biodegradation. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, HPLC of Formula: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zheng, Xubin published the artcileA dual-emitting Tb(III)&Yb(III)-functionalized coordination polymer: a “”turn-on”” sensor for N-methylformamide in urine and a “”turn-off”” sensor for methylglyoxal in serum, Synthetic Route of 123-39-7, the main research area is terbium ytterbium coordination polymer methylformamide methylglyoxal.

Fluorescent materials with lanthanide cations encapsulated in MOFs are currently used in numerous applications, especially in biosensors. Therefore, herein, two novel composites were designed and developed based on a Tb(III)&Yb(III)-functionalized Cu(II)-coordination polymer, possessing higher thermal and water stability and fascinating fluorescence properties. The first bimetallic composite Tb@Cu-Hcbpp demonstrated broad ligand-centered emission and weak typical Tb3+ ion emission; moreover, it was used as an excellent ratiometric fluorescent sensor for the metabolic product NMF of DMF in the human body (LOD = 0.02μM). In addition, the Yb3+ ions were doped into Tb@Cu-Hcbpp to improve the fluorescence performance of the green Tb3+ ion emission. Among the series of Tb1-xYbx@Cu-Hcbpp samples (x = 0.05, 0.10, 0.15, 0.20, 0.25, 0.30, 0.35 and 0.40), Tb0.85Yb0.15@Cu-Hcbpp showed maximum enhanced fluorescence intensity (almost 9.6 times that of the pure terbium system), but exhibited high fluorescence quenching efficiency for methylglyoxal (MGO), which could be used for the sensitive detection of MGO (LOD = 0.25μM). Furthermore, the developed biosensors were successfully applied for the detection of NMF and MGO in urine and serum samples, and satisfactory results were obtained, showing good potential of these biosensors in practical applications such as in disease diagnosis and biochem. research.

Dalton Transactions published new progress about Blood analysis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics