Category: amides-buliding-blocks

Rayala, Nagamani published the artcileAcid catalyzed multicomponent one-pot synthesis of new quinazolinone based unsymmetrical C-N linked bis heterocycles, Recommanded Product: N-Methylformamide, the main research area is dihydroquinazolinyl hexahydroacridine dione preparation; aminoquinazolinone cyclohexanedione aldehyde multicomponent condensation cyclization hydrochloric acid catalyst.

A novel series of unsym. C-N linked bis heterocycles bearing quinazolinone and acridinedione skeletons I (R = Ph, thiophen-2-yl, 2-chloroquinolin-3-yl, etc.) have been synthesized in an acid promoted one pot multicomponent reaction. A blend of 6-aminoquinazolin-4-(3H)-one, aromatic aldehydes RCHO and cyclohexane-1,3-dione in a simple and efficient condensation-cyclization reaction using hydrochloric acid in catalytic amount as catalyst afforded unsym. bis hybrids in good to excellent yields. Multiheterocyclic hybrid compounds I were also synthesized using heterocyclic ring containing aldehyde in three component reaction. The synthesized quinazolinone-acridindione hybrids I were characterized using spectroscopic techniques.

Asian Journal of Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Metternich, Jan B. published the artcileAsymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co-Catalyzed, Enantioselective Proton-Transfer, Application In Synthesis of 343338-28-3, the main research area is pentadienone Lewis acid catalyst enantioselective Nazarov cyclization; cyclopentenone preparation; Lewis acid; Nazarov; catalysis; electrocyclization; enantioselective; physical organic.

Enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids was reported. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C-C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis.

Advanced Synthesis & Catalysis published new progress about Alkadienones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application In Synthesis of 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Yanling published the artcileEfficient Pd-Catalyzed Hydrodehalogenation of o-Haloanilides in Water, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is anilide green preparation; haloanilide regioselective hydrodehalogenation palladium catalyst.

A practical methodol. for the synthesis of anilides RC(O)NHPh [R = Me, Bn, 4-FC6H4, etc.] via hydrodehalogenation of o-haloanilides using PdCl2 at 100°C under mild conditions in water was developed. The catalytic system could selectively dehalogenate both aryl chloride and aryl bromide and exhibit a broad functional group tolerance.

Synlett published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tian, Chao published the artcileVisible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives, Computed Properties of 7465-88-5, the main research area is visible light regioselective ortho trifluoromethylation aniline Langlois reagent photocatalyst.

A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the “”CF3″” source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives

Journal of Organic Chemistry published new progress about Photocatalysts. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lei, Gaiying published the artcileIn situ preparation of amphibious ZnO quantum dots with blue fluorescence based on hyperbranched polymers and their application in bio-imaging, COA of Formula: C2H5NO, the main research area is zinc oxide quantum dot blue fluorescence hyperbranched polymer; amphibious ZnO quantum dots; bio-imaging; blue fluorescence; hyperbranched polymers.

A new strategy for preparing amphibious ZnO quantum dots (QDs) with blue fluorescence within hyper-branched poly(ethylenimine)s (HPEI) was proposed in this paper. By changing [Zn2+]/[OH-] molar ratio and heating time, ZnO QDs with a quantum yields (QY) of 30% in ethanol were obtained. Benefiting from the amphibious property of HPEI, the ZnO/HPEI nanocomposites in ethanol could be dissolved in chloroform and water, acquiring a QY of 53%, chloroform and 11% in water. By this strategy, the ZnO/HPEI nano-composites could be applied in not only in optoelectronics, but also biomedical fields (such as bio-imaging and gene transfection). The bio-imaging application of water-soluble ZnO/HPEI nanocomposites was investigated and it was found that they could easily be endocytosed by the COS-7 cells, without transfection reagent, and they exhibited excellent biol. imaging behavior.

Polymers (Basel, Switzerland) published new progress about Dialysis Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jianjian published the artcileChalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides, Related Products of amides-buliding-blocks, the main research area is chiral sulfoxide preparation enantioselective regioselective; sulfinyl dibenzaldehyde alc esterification.

Conformational isomerization can be guided by weak interactions such as chalcogen bonding (ChB) interactions. Here authors report a catalytic strategy for asym. access to chiral sulfoxides by employing conformational isomerization and chalcogen bonding interactions. The reaction involves a sulfoxide bearing two aldehyde moieties as the substrate that, according to structural anal. and DFT calculations, exists as a racemic mixture due to the presence of an intramol. chalcogen bond. This chalcogen bond formed between aldehyde (oxygen atom) and sulfoxide (sulfur atom), induces a conformational locking effect, thus making the sym. sulfoxide as a racemate. In the presence of N-heterocyclic carbene (NHC) as catalyst, the aldehyde moiety activated by the chalcogen bond selectively reacts with an alc. to afford the corresponding chiral sulfoxide products with excellent optical purities. This reaction involves a dynamic kinetic resolution (DKR) process enabled by conformational locking and facile isomerization by chalcogen bonding interactions.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Bo-Han published the artcileHighly Site-Selective Oxidative Cyclization of Ene-ynamides via Non-Noble-Metal Catalysis: Access to Functionalized Lactams, Category: amides-buliding-blocks, the main research area is lactam preparation diastereoselective regioselective mechanism; chiral lactam preparation diastereoselective regioselective enantioselective mechanism; ene ynamide tandem oxidative cyclization non noble metal catalyst.

Herein, an unprecedented non-noble-metal-catalyzed oxidation/cyclization of ene-ynamides, e.g., R1CCN(R)CH(R2)C(R3):C(Me)R4 (R = Ms, Ts, Bs, benzenesulfonyl; R1 = Ph, 4-chlorophenyl, thiophen-2- yl, etc.; R2 = H, Et, allyl, prop-2-yn-1-yl; R3 = H, Me; R4 = Me, Ph), is developed, allowing the synthesis of diversely functionalized lactams, e.g., I and II, in moderate to good yields with excellent diastereoselectivities without the observation of typical cyclopropanation products. In combination with Ellman′s tert-butylsulfinimine chem., chiral γ-lactams containing three contiguous stereocenters are obtained with high diastereo- and enantioselectivity. Moreover, d. functional theory (DFT) calculations indicate that this protocol probably undergoes a carbon cation or proton transfer process.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liang, Hao published the artcileChiral Arene Ligand as Stereocontroller for Asymmetric C-H Activation, SDS of cas: 343338-28-3, the main research area is chiral arene ruthenium ligand preparation; isoquinolone preparation regioselective enantioselective; amide alkyne carbon hydrogen activation; Asymmetric C−H Activation; Axially Chiral; Chiral Arene Ligand; Ruthenium; [2.2]Paracyclophane.

Development of chiral ligands is the most fundamental task in metal-catalyzed asym. synthesis. In the last 60 years, various kinds of ligands have been sophisticatedly developed. However, it remains a long-standing challenge to develop practically useful chiral η6-arene ligands, thereby seriously hampering the asym. synthesis promoted by arene-metal catalysts. Herein, the design and synthesis of a class of readily tunable, C2-sym. chiral arene ligands derived from [2.2]paracyclophane is reported. Its ruthenium(II) complexes have been prepared and successfully applied in the enantioselective C-H activation to afford a series of axially chiral isoquinolones (up to 99% yield and 96% ee). This study not only lays chemists’ longstanding doubts about whether it is possible to use chiral arene ligands to stereocontrol ruthenium(II)-catalyzed asym. C-H activation, but also opens up a new avenue to achieve asym. C-H activation.

Angewandte Chemie, International Edition published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, SDS of cas: 343338-28-3.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Salah, Kennouche published the artcileStereoselective Synthesis of Biheterocycles Containing Indole and 5,6-Dihydropyridin-2(1H)-one or α-methylene-β-butyrolactam Scaffolds, Application of (S)-2-Methylpropane-2-sulfinamide, the main research area is biheterocycle containing indole preparation; dihydropyridinone preparation; alpha methylene beta butyrolactam scaffold preparation.

Indium-mediated allylation of N-tert-butanesulfinyl imines derived from indole-2 and 3-carbaldehydes I [R1 = H, Me, Et; R2 = H, 4-Br, 5-OMe, etc.] and II with allylic bromides, proceed with high diastereoselectivity. Homoallylic amide derivatives were transformed into dihydropyridinones, e.g., III and IV, upon successive desulfinylation, N-acylation with acryloyl chloride and ring-closing-metathesis. Desulfinylation of amine ester derivatives obtained when Et 2-(bromomethyl)acrylate was used as the allylating reagent, led to the corresponding α-methylene-β-butyrolactams in modest yields.

ChemistrySelect published new progress about Lactams Role: SPN (Synthetic Preparation), PREP (Preparation). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Application of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Baek, Kyung-Youl published the artcileCore-Functionalized Star Polymers by Transition Metal-Catalyzed Living Radical Polymerization. 1. Synthesis and Characterization of Star Polymers with PMMA Arms and Amide Cores, SDS of cas: 10405-38-6, the main research area is star PMMA preparation functionalized divinyl core; microgel divinyl core PMMA star; amide microgel core PMMA star.

A series of microgel core-functionalized star-shaped polymers was synthesized by the polymer linking reaction method in RuCl2(PPh3)3-catalyzed living radical polymerization The synthesis was achieved by the polymer linking reaction method; i.e., functionalized divinyl compounds were added in situ to the solution of linear living poly(MMA)s prepared with the Ru(II)-catalyzed living radical polymerization The functionalized microgel cores thus obtained contained acrylamide and methacrylamide. Also, star polymers with varying densities of the microgel cores were prepared from diacrylamides with various lengths and structures of the spacer, and by changing the relative amounts of MMA (arm length) and divinyl compound (core size) to initiator, a variety of core-functionalized star polymers could be obtained in high yield. These core-functionalized star-shaped polymers have f of 20-640, Mw of 3.3 × 105-1.3 × 107, and Rz of 5-42 nm. These results indicated that the cores carry as many as 440-51,000 amide groups in microgel networks.

Macromolecules published new progress about Radius of gyration. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, SDS of cas: 10405-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics