Category: amides-buliding-blocks

Patel, Khushbu P. published the artcileGraphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions, Recommanded Product: N-Methylformamide, the main research area is amide preparation green chem solventless; amine carboxamide transamidation graphene oxide catalyst.

An environment-friendly, inexpensive, carbocatalyst, graphene oxide (GO) which promoted efficient, metal-free transamidation of various carboxamides RC(O)NH2 (R = Ph, pyridin-2-yl, H, Me, etc.) with aliphatic, cyclic, and aromatic amines NH(R1)(R2) [R1 = H, Ph; R2 = n-Bu, Ph, cyclohexyl, pyridin-2-yl, etc.; R1R2 = -(CH2)4-, -CH2CH2OCH2CH2-] and 2-aminothiophenol is demonstrated. The protocol is equally applicable to phthalimides such as 1H-isoindole-1,3(2H)-dione, 5-methyl-1H-isoindole-1,3(2H)-dione, ureas R3NHC(O)NH2 (R3 = H, Ph), and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (-C=O), epoxy (-O-), carboxyl (-COOH) and hydroxyl (-OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products RC(O)N(R1)(R2), I, R1NHC(O)NHR2 in good to excellent yields. The one-pot synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramol. transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity.

Advanced Synthesis & Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Feng published the artcileMoS2-Catalyzed transamidation reaction, Synthetic Route of 123-39-7, the main research area is amine amide molybdenum disulfide catalyst transamidation.

The MoS2-catalyzed transamidation reaction with high yields using N,N-dimethylformamide and other amides as carbonyl sources was developed. The protocol was simple, does not required any additive such as acid, base, ligand, etc., and encompassed a broad substrate scope for primary, secondary and heterocyclic amines. Moreover, the acetylation and propanylation of amines also could be achieved with good to excellent yield by this strategy.

Scientific Reports published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Feng published the artcileMetal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions, Name: N-Methylformamide, the main research area is tertiarybutyl arylperoxoate preparation potassium tertiary butoxide mediator amidation; arylamide preparation green chem.

An efficient and practical approach for amide synthesis was described. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40°) in air and readily available formamides were used as an amino source. This reaction was easily upgraded to the gram level with an excellent yield.

Scientific Reports published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Minxuan published the artcileK3PO4-Promoted domino reactions: diastereoselective synthesis of trans-2,3-dihydrobenzofurans from salicyl N-tert-butanesulfinyl imines and sulfur ylides, Product Details of C4H11NOS, the main research area is trans dihydrobenzofuran preparation chemoselective enantioselective diastereoselective; salicyl tert butylsulfinyl imine preparation sulfur ylide domino annulation.

An efficient domino annulation between sulfur ylides and salicyl N-tert-butylsulfinyl imines was developed. The reaction proceeded with a diastereodivergent process, the configuration of the sulfinyl group determining the stereochem. course of the reaction. The method allowed the synthesis of a highly substituted trans-2,3-dihydrobenzofuran skeletons I [R1 = H, 4-Cl, 4-Me, 4-NO2; R2 = H; R3 = H, Cl, Br; R4 = H, Cl; R2R3 = CH:CC:CH] with high yield and good chemo- and diastereoselectivity.

RSC Advances published new progress about Chemoselectivity. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Product Details of C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reis Conceicao, Nuno published the artcileKnoevenagel condensation reaction in supercritical carbon dioxide medium using a Zn(II) coordination polymer as catalyst, Product Details of C2H5NO, the main research area is zinc coordination polymer catalyst preparation benzaldehyde Knoevenagel condensation reaction.

The replacement of conventional organic solvents by the so-called “”green solvents”” is a usual approach to more sustainable chem. processes. Supercritical carbon dioxide (scCO2) has been successfully regarded as a candidate for such a purpose. Moreover, it possesses moderate critical pressure and temperature conditions and may be easily separated from the catalytic system by a simple depressurization. In the present work, the new Zn(II) coordination polymer [Zn(L1)(NMeF)]n·n(NMeF) (Zn-CP 1) is reported, being prepared by the solvothermal reaction of 5-{(pyren-4-ylmethyl)amino}isophthalic acid (H2L1) with Zn(NO3)2·6H2O in N-methylformamide (NMeF). The SCXRD anal. revealed that Zn-CP 1 has a 1D double chain type of structure. Its potential as catalyst was studied in the Knoevenagel condensation of benzaldehyde and malononitrile as a model reaction under mild conditions, in scCO2 medium. An increasing trend was observed in the reaction yield as we moved from aprotic (THF) to protic (EtOH and H2O) polar co-solvents, reaching the full conversion in the case of water. It was found that scCO2, in the absence of a protic co-solvent, is not the most suitable medium for this reaction. The catalyst can be recycled without a considerable loss of activity; SEM, PXRD, FT-IR and TGA analyzes indicate its high stability throughout the process.

Inorganica Chimica Acta published new progress about Crystal structure. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kharaneko, A. O. published the artcileSynthesis and Modification of Hetero-Fused Pyrazoles Derived from Methyl 1-(2-Oxo-2-phenylethyl)-3-phenyl-1H-pyrazole-5-carboxylate, Application In Synthesis of 123-39-7, the main research area is hetero fused pyrazole preparation.

A modified procedure has been proposed for the synthesis of 2,7-diphenyl-5,8-dihydro-4H-pyrazolo[5,1-d][1,2,5]triazepin-4-one, and the possibility of transformation of the latter to the pyrazolo[1,5-a]pyrazine system has been demonstrated. Functionalization of 2,7-diphenyl-5,8-dihydro-4H-pyrazolo[5,1-d][1,2,5]triazepin-4-one at the 4-position and fusion of a tetrazole or triazole ring at the C4-N5 bond have been performed.

Russian Journal of Organic Chemistry published new progress about Heterocyclization. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kodama, Yuki published the artcileStereoselective synthesis of highly functionalized (Z)-chloroalkene dipeptide isostere containing an α,α-disubstituted amino acid, Safety of (S)-2-Methylpropane-2-sulfinamide, the main research area is chloroalkene dipeptide isostere enantioselective diastereoselective synthesis disubstituted amino acid; ketimine Aza Darzens condensation dichloroenolate aldimine; cyclization mechanism transition state free energy NBO DFT; quaternary carbon center spirocyclic crystal mol structure packing.

Described here is the first stereoselective synthesis of highly functionalized chloroalkene dipeptide isosteres containing an α,α-disubstituted amino acid (ααAA). This synthesis requires the construction of a quaternary carbon center, and this challenge was overcome by the Aza-Darzens condensation of ketimine with α,α-dichloroenolate, producing 2-chloroaziridines with quaternary carbon centers including spirocyclic motifs, which are valuable for the previously elusive synthesis of various α,α-AA-containing chloroalkene isosteres.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino acids Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (disubstituted). 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, Safety of (S)-2-Methylpropane-2-sulfinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Turlik, Aneta published the artcileMechanism and Origins of Stereoselectivity of the Aldol-Tishchenko Reaction of Sulfinimines, COA of Formula: C4H11NOS, the main research area is sulfinimine stereoselective aldol Tishchenko reaction.

D. functional theory computations have elucidated the mechanism and origins of stereoselectivity in McGlacken’s aldol-Tishchenko reaction for the diastereoselective synthesis of 1,3-amino alcs. using Ellman’s t-butylsulfinimines as chiral auxiliaries. Variations of stereochem. outcome are dependent on the nature of the ketone starting materials used, and the aspects leading to these differences have been rationalized. The intramol. hydride transfer step is the rate- and stereochem.-determining step, and all prior steps are reversible.

Journal of Organic Chemistry published new progress about Aldol addition. 343338-28-3 belongs to class amides-buliding-blocks, name is (S)-2-Methylpropane-2-sulfinamide, and the molecular formula is C4H11NOS, COA of Formula: C4H11NOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zou, Long published the artcileVisible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst, Formula: C14H13NO2, the main research area is regioselective trifluoromethylation acetaniline photocatalysis.

A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Optimization. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Formula: C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rottlander, Mario published the artcileMultiple cross-coupling reactions of aryl and benzylic zinc halides with aryl halides and triflates in solid-phase synthesis of polyfunctional aromatics, Formula: C5H4BrNOS, the main research area is aryl zinc halide aryl halide coupling; benzyl zinc halide aryl triflate coupling; cross coupling solid phase aryl halide; benzene solid phase synthesis.

Aryl and benzylic zinc bromides undergo efficient Pd(0)-catalyzed cross-coupling reactions on the solid-phase using either Rink or Wang resin. By performing the cross-couplings with the multi-coupling reagents 4-BrZnCH2C6H4O2CCF3 and 4-BrZnC6H4OSi(CHMe2)3, two successive C-C bond forming reactions are possible on the solid-phase.

Synlett published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 189329-94-0 belongs to class amides-buliding-blocks, name is 5-Bromothiophene-3-carboxamide, and the molecular formula is C5H4BrNOS, Formula: C5H4BrNOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics