Category: amides-buliding-blocks

Ko, Ik Jang; Park, Jin Hwan; Kim, Gyeong Woo; Lampande, Raju; Kwon, Jang Hyuk published an article in 2019, the title of the article was High-Performance Reflective Electrochromic Device by Integrating White Reflector and High Optical Density Electrochromic System.Quality Control of N,N-Diethylacetamide And the article contains the following content:

This paper reports an efficient reflective electrochromic device (ECD) by integrating a highly reflective micro-porous titanium dioxide-based white reflector film and an optimized transparent to black convertible electrochromic (EC) system. This reflective ECD can reflect almost 58.5% of light in the white state and 4.7% in the dark black state at 550 nm. Similarly, it also exhibits a very high ambient contrast ratio of 38:1 under office ambient light condition and good driving stability of about 83% in the white state (0 V) and 98% in the black state (1.7 V) after 10 000 driving cycles. In addition, the EC system is optimized by selecting good proton generator and suitable solvent for better coloration property as well as a low driving voltage via lactone ring opening reaction of leuco dye and supporting polymer for high optical d. through suppressing the movement of oxidized leuco dye to the electrode. An ECD with the optimized EC system shows significant improvement in average optical d. from 0.62 to 1.9 (at 400 to 700 nm) and faster switching speeds of about 1.6 s. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Quality Control of N,N-Diethylacetamide

The Article related to titanium dioxide white reflector electrochromic device optical density, Placeholder for records without volume info and other aspects.Quality Control of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dahlbom, Richard; Misiorny, Alfons published an article in 1957, the title of the article was Amines related to adrenaline containing nuclear chlorine.Formula: C18H19NO3 And the article contains the following content:

Nuclear substituted amino ketones were prepared from appropriate ω-chloroacetophenones and the desired amines. E.g., the appropriate ω-chloroacetophenone (0.025 mole) and the amine (0.065 mole) were dissolved in toluene (usually 25 ml.) and the mixture kept overnight at room temperature The amine hydrochloride was removed by filtration and the toluene solution washed with water and extracted with 2N HCl. The extract was made alkaline with aqueous Na2CO3 and the precipitated base extracted with Et2O. The extract was dried over Na2SO4 and the amino ketone was then isolated as the hydrochloride by the addition of ethereal HCl and recrystallized These compounds were of the general formula 3,4-R’RC6H3COCH2R”.HCl with R, R’, R”, and m.p. given: Cl, H, piperidino (I), 222-3° (free amine, m. 52-3°); OH, Cl, I, 268-270°; Cl, Cl, I, 249-51°; Cl, H, NHEt, 246-8°; Cl, H, 4-methyl-1-piperazinyl (II), 248-9°; Cl, Cl, II, 252-4°; Cl, H, 4-ethyl-1-piperazinyl, 266-8°; Cl, H, 4-carbethoxy-1-piperazinyl (III), 196-7°; Cl, Cl, III, 212-14° (free amine, m. 108-9°). Most of these amine hydrochlorides m. with decomposition and the yields were 41-87%. The hydrochlorides were converted to the free amino ketones which were dissolved in Et2O and reduced with LiAlH4 to give the following corresponding amino alcohols with R, R’, R”, and m.p. given in that order; Cl, H, I, 68.5-70°; Cl, Cl, I, 89-90°; Cl, H, NHEt, b0.8 190°, m. 87-8°; Cl, H, II, 85-85.5° (hydrochloride, m. 236-7°); Cl, Cl, II, 121-2°. A weak antagonism toward adrenaline and noradrenaline was shown by several of the piperidino compounds in experiments on the blood pressure of cats. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Formula: C18H19NO3

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Formula: C18H19NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dornow, Alfred; Siebrecht, Manfred published an article in 1960, the title of the article was Syntheses of nitrogen-containing heterocycles. XXII. The synthesis of some pyrazolo[3,4-b]pyridines.Product Details of 100524-09-2 And the article contains the following content:

5-Amino-3-pyrazolone (I) with β-dicarbonyl compounds gave good yields of pyrazolopyridines. AcMeCHCHO (II) condensed with I gave as the main product the corresponding pyrazolopyrimidine. NCCH2CONHNH2 (99 g.) and 89 g. NaOEt in 400 cc. EtOH heated 1 hr. at 100°-cooled, and filtered gave 116 g. Na salt (III) of I; the concentrated aqueous solution of III acidified with glacial AcOH gave I, m. 204°. III (12.1 g.) in 45 cc. H2O treated with stirring and warming with 13.0 g. AcCH2CO2Et to solution, cooled, filtered, and the residue dissolved in H2O and acidified with AcOH gave 16.2 g. 3,6-dihydroxy-4-methyl-1-pyrazolo [3,4-b]pyridine (IV), m. 335° (decomposition) (MeOH). CH2(CO2Et)2 (8 g.) and 4.95 g. I added to 10.5 g. NaOEt in 100 cc. EtOH, heated 4 hrs. on the water bath and filtered, and the residue dissolved in H2O and acidified with AcOH gave 7.1 g. 4-OH analog of IV, m. 370° (decomposition) (glacial AcOH). III (12.1 g.) in 30 cc. H2O, 11.1 g. AcCH: CHONa in 15 cc. H2O, and 2.5 g. piperidine acetate refluxed 2 hrs., cooled, neutralized with AcOH, and filtered gave 9.9 g. 3-hydroxy-6-methyl-1-pyrazolo[3,4-b]pyridine (V), m. 282° (EtOH). III (6 g.) in 30 cc. H2O treated with 8.5 g. BzCH:CHONa in 20 cc. H2O, heated 2 hrs. with 2 g. piperidine acetate on the water bath, cooled, and acidified with glacial AcOH yielded 6.7 g. 6-Ph analog of V, m. 288° (MeOH). III (6 g.) in 20 cc. H2O treated with 6 g. Na salt of II in 10 cc. H2O, refluxed 2 hrs. with 2 g. piperidine acetate, and worked up gave 5.1 g. orange precipitate; the precipitate extracted with hot EtOH and the extract cooled gave 3.4 g. 2-hydroxy-6,7-dimethylpyrazolo[2,3-a]pyrimidine (VI), m. 239° with sintering from 226° (EtOH); the residue from the extraction gave 1.7 g. 5-Me derivative (VII) of V, m. 343°. I (3 g.) and 3.7 g. Na salt of 1-formyl-2-cyclohexanone in 40 cc. absolute EtOH refluxed 2 hrs., filtered after 2 hrs., and the residue dissolved in H2O and neutralized with glacial AcOH yielded 3.4 g. 3-hydroxy-5,6,7,8-tetrahydro-1-pyrazolo[3,4-b]quinoline (VIII), yellow, m. 297° (EtOH). IV (1 g.) and 10 g. Raney Ni in 230 cc. EtOH refluxed 2 hrs., filtered hot, evaporated, and the residue washed with Et2O gave 0.65 g. 6-hydroxy-2-amino-4-methylnicotinic acid amide (IX), m. 250° (PhMe). V (0.5 g.) and 8 g. Raney Ni in 200 cc. EtOH gave similarly 0.45 g. 2-amino-6-methylnicotinic acid amide (X), m. 219° (PhMe). VII (0.5 g.) and 8 g. Raney Ni refluxed 3 hrs. in 200 cc. EtOH yielded 0.5 g. 5-Me derivative of X, m. 230° (PhMe). VIII (2 g.) and 12 g. Raney Ni in 300 cc. EtOH heated 3 hrs. gave 1.2 g. amide (XI) of 2-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acid (XII), m. 223° (PhMe). XI (0.7 g.) in 5 cc. concentrated HCl refluxed 3 hrs. and neutralized with aqueous NaOH-NaOAc gave 0.6 g. XII. XII (3 g.) distilled at 250° gave with CO2 evolution 2.1 g. 2,4,5-trimethylpyrimidine, b12 107°; picrate m. 198° (EtOH). The experimental process involved the reaction of 2-Amino-6-methylnicotinamide(cas: 100524-09-2).Product Details of 100524-09-2

2-Amino-6-methylnicotinamide(cas:100524-09-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Product Details of 100524-09-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1956, the title of the article was Synthesis of aegelin.Application of 456-12-2 And the article contains the following content:

Anisaldehyde was converted to the corresponding cyanohydrin which was oxidized and with catalytic hydrogenation yielded β-hydroxy-β-p-methoxyphenylethylamine, which with cinnamoylation yielded aegelin. Dihydroaegelin, aegelone, and dihydroaegelone were synthesized in a similar manner. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Application of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nerdel, Friedrich; John, Ute published an article in 1956, the title of the article was Hydratropic acids. V. Optically active m- and p-substituted homohydratropic acids.Product Details of 456-12-2 And the article contains the following content:

cf. C.A. 49, 13938c. Methylation of p-O2NC6H4CH2CHMeCO2H (I) with CH2N2 in EtOH yields 93% Me ester, b0.002 90°, m. 57° (amide, needles, m. 116°). I (60 g.) in 100 cc. (Me2CH)2O with 50 g. (+)-bornylamine (II) in 50 cc. (Me2CH)2O yields almost 100% II salt, m. 161-3°, [α]D20 11°, which, on fractional crystallization from C6H6 gives 38 g. (-)-salt, m. 168-9°, [α]D20 -3.5°; decomposition of the latter yields (-)-I, needles, m. 107°, [α]D20 -32.4° (EtOH) [Me ester, sirup, [α]D20 -49.1° (EtOH); amide, m. 112-13°, [α]D20 -60.5° (EtOH)]. m-O2NC6H4CH2CHMeCO2Me b0.05 100° (amide, small needles, m. 113°). m-O2NC6H4CH2CHMeCO2H (III) (95 g.) with 65 g. II gives the II salt, m. 144-6° [α]D20 13.4°, which, fractionally crystallized from C6H6, yields 50 g. II salt of (-)-III, m. 159-60°, [α]D20 0°; free (-)-III, m. 69-70°, [α]D20 -24°; quinine salt, m. 83-5°, does not change the rotation; Me ester, b0.001 85°, [α]D20 -40.1°; amide, needles, m. 135°, [α]D20 -61.6°. Reduction of 6.3 g. I in 75 cc. EtOH 20 min. with 0.2 g. PtO2 yields the p-NH2 acid (IV).HCl, pale yellow needles, m. 191° (decomposition); free IV, needles, m. 126°. Reduction of (-)-I in the same way yields (-)-IV, m. 191° (decomposition), [α]D20 -46° (H2O); N-Ac derivative of (-)-IV, prisms, m. 129°, [α]D20 -22.4° (EtOH). Reduction of III with PtO2 in EtOH gives m-H2NC6H4CH2CHMeCO2H (V), m. 99°. Hydrogenation of m-O2NC6H4CH:CMeCO2H gives, after 3 moles H are absorbed, m-H2NC6H4CH:CMeCO2H, m. 137°; further hydrogenation yields V. (-)-V, m. 94°, [α]D20 -14.3°; HCl salt, m. 136°, [α]D20 -42.8°. N-Ac derivative of V, prisms, m. 137°; N-Ac derivative of (-)-V, prisms, m. 123°, [α]D20 -21° (EtOH). Diazotizing IV.HCl at 0° and heating the diazonium solution at 50° give p-HOC6H4CH2CHMeCO2H (VI), needles, m. 102° (-)-VI, m. 99°, [α]D20 -18.5° (EtOH). m-HOC6H4CH2CHMeCO2H (VII) is an oil; (-)-VII, needles, m. 98°, [α]D20 -15.2° (EtOH). Diazotizing a 54% optically pure (-)-IV and heating the diazonium solution with CuH2 yield (-)-PhCH2CHMeCO2H, [α]D20 -14°, corresponding to an [α]D20 of -26° for the optically pure acid. Hydrogenating PhCH:CMeCO2H with NaHg and resolving the acid with quinine yield a quinine salt, m. 122°, [α]D20 116.2°; free (+)-acid, [α]D20 22.9°, d20 1.062; Me ester, b22 230°, d22 1.017, [α]D20 30.1°; (+)-amide, needles, m. 115°. The rotation dispersion of the substituted homohydratropic acids, their esters, and amides are listed in tables and show that the rotation direction is not changed by the entrance of m- and p-substituents. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Product Details of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chakravarti, R. N.; Dasgupta, B. published an article in 1958, the title of the article was Structure of aegelin.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

cf. C.A. 50, 11281h. Air-dried powd. young leaves (14 kg.) of Aegle marmelos (May-Aug. crop) repeatedly extracted with cold 90% alc. and the extract mixed with filter paper pulp, dried at 80° and extracted 80 hrs. with Et2O, the extract evaporated to 1.5 l. and kept at 0° 1 week, filtered and the product washed with Et2O, crystallized from EtOAc and EtOH-Me2CO and the crystalline product filtered in alc. through Al2O3, the filtrate evaporated and the residue crystallized (alc.) gave 0.15-0.20% aegelin (I), C18H19NO3, m. 178-9°, evolving little H2Se on heating with Se (cf. Chatterjee and Bose, C.A. 47, 10544g), λ 212, 219, 275 mμ (log ε 4.36, 4.36, 4.42) similar to that of trans-PhCH:CHCONHMe, λ 218, 270 mμ (log ε 4.18, 4.39); acetate, m. 123-5°; benzoate, m. 147-8°. I (0.5 g.) in 25 ml. AcOH shaken 4 hrs. at 30° with portionwise addition of 0.2 g. CrO3 and excess AcOH evaporated in vacuo, the residue diluted with H2O and the mixture filtered, gave 0.35 g. aegelone (II), C18H17 159-60° (alc.), λ 280 mμ (log ε 4.67), reducing hot AgNO3NH4OH solution in 1 min., no reaction with Angeli-Rimini or Schiff reagents; semicarbazone, m. 234-5°. I (0.5 g.) hydrogenated 15 min. in 25 ml. AcOH with 50 mg. prereduced PtO2 at 30°/760 mm. and the filtered solution evaporated in vacuo, the residue taken up in H2O and filtered gave 0.33 g. dihydroaegelin (III), m. 140-1° (alc.), similar to I in not reducing AgNO3-NH4OH on heating several min. at 100°, oxidized by CrO3 to the corresponding dihydroaegelone (IV), m. 126-7° (alc.), reducing AgNO3-NH4OH solution; semicarbazone, m. 138-40°. IV was also obtained by partial hydrogenation of 0.5 g. II in 20 ml. AcOH with 50 mg. prereduced PtO2. IV (0.5 g.) in 25 ml. AcOH hydrogenated 30 min. by shaking with 50 mg. prereduced PtO2 and the filtered solution evaporated in vacuo gave III. I (1 g.) in 10 ml. boiling H2O treated portionwise with 4 g. KMnO4 and 0.5 g. KOH in 100 ml. H2O and excess KMnO4 decomposed with MeOH, the solution filtered and concentrated to 20 ml., the cooled concentrate acidified with HCl, and the precipitate (0.4 g.) repeatedly crystallized (hot H2O) gave p-anisic acid, m. 183-4°, and BzOH. Oxidation of I under similar conditions and distillation gave BzH, converted to 60 mg. 2,4-(O2N)2C6H3NHN:CHPh. I (2 g.) refluxed 8 hrs. with 72 ml. 90% alc. and 12 ml. concentrated HCl and the solution steam distilled, the 2nd fraction of the distillate extracted with Et2O and the extract washed with aqueous NaHCO3 and H2O, the dried extract evaporated and the oil (0.427 g.) warmed 0.5 hr. with aqueous H2NNHCONH2.HCl and NaOAc in a min. of alc., kept overnight and decanted, the product washed with H2O and Et2O and the crystalline residue (45 mg.) crystallized (alc.) gave p-MeOC6H4CH:NNHCONH2, m. 203-4°. The oil from the Et2O washings hydrolyzed with 10% alc. KOH and the alc. evaporated, the aqueous solution acidified with HCl and the product crystallized (hot H2O) gave trans-PhCH:CHCO2H (V). The distillation residue steam distilled and extracted with Et2O (extract A) and the aqueous layer (solution B) basified with evolution of NH3, extracted with Et2O and the product (basic crystals) acidified and treated with Meyer reagent gave a creamy precipitate The presence of NH3 in the hydrolysis products of I was confirmed by evaporating solution B to dryness and heating the residue with alkali, adsorbing the evolved gas in alc. and treating the solution with 1,2,4-ClC6H3(NO2)2. Extract A extracted with aqueous NaHCO3 and the extract acidified with HCl gave 0.32 g. V. Hydrogenation of 1.3 g. p-MeC6H4COCN in 15 ml. AcOH 20 min. with 0.1 g. prereduced PtO2 at 30°/760 mm., the dark brown filtered solution treated with 0.46 ml. concentrated H2SO4 and diluted with Et2O gave 1.3 g. p-MeOC6H4COCH2NH2.H2SO4 (VI), m. 167-8° (AcOH) (cf. Kindler and Peschke, C.A. 26, 3785). VI (0.3 g.) and 0.3 ml. trans-PhCH:CHCOCl stirred with gradual addition of 10% NaOH to appearance of pink coloration, the solution stirred with 0.2 ml. trans-PhCH:CHCOCl and the colorless solution made alk. gave 0.2 g. p-MeOC6H4COCH2NHCOCH:CHPh, m. 156-60° (cf. Lister and Robinson, C.A. 7, 326), identical with II, and dehydrated with concentrated H2SO4 to 5-p-methoxyphenyl-2-styryloxazole, showing intense blue fluorescence in solution VI (0.3 g.) and 0.3 ml. PhCH2CH2COCl stirred with cooling with 10% NaOH and the brick-red product crystallized (alc.) gave 0.2 g. p-MeOC6H4COCH2NHCOCH2CH2Ph, m. 126-7°, identical with IV. VI (0.7 g.) in 15 ml. AcOH and 2 ml. H2O hydrogenated 45 min. at 30°/760 mm. with 50 mg. prereduced Pt2O and again hydrogenated 20 min. with 50 mg. catalyst, the filtered solution evaporated in vacuo and the residue in H2O divided, a portion condensed with 0.3 ml. PhCH:CHCOCl to give 0.15 g. I and the other portion condensed with 0.3 ml. PhCH2CH2COCl gave III. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chaudhury, N. Aditya; Chatterjee, A. published an article in 1959, the title of the article was β-Phenylethanolamines. I. New synthesis of aegeline and papaverine.Electric Literature of 456-12-2 And the article contains the following content:

cf. C.A. 52, 14630i. Substituted benzaldehyde cyanohydrins are reduced to the corresponding amines, condensed with piperonal (I), and converted to the N-Me derivatives Thus, 6 g. p-MeOC6H4CH(OH)CN in 50 cc. Et2O is added dropwise to 4 g. LiAlH4 in 200 cc. Et2O at 0°, the mixture stirred at room temperature 5-6 hrs., refluxed 4-5 hrs., the complex decomposed by addition of 5 cc. H2O, 10 cc. 20% aqueous NaOH, and 15 cc. H2O and refluxed 30 min. The solution is filtered hot, extracted with 150 cc. Et2O and β-hydroxy-β-(p-methoxyphenyl)ethylamine (II) (80%), m. 70° (C6H6-petr. ether), isolated by evaporation of the Et2O. II.HCl m. 173°. Equal moles of I and II are refluxed in 95% EtOH 1 hr. and the solvent evaporated in vacuo to give N-piperonylidene-β-hydroxy-β-(p-methoxyphenyl)ethylamine (III) (90-5%), needles, m. 115-16° (C6H6-petr. ether). III (3 g.) in 100 cc. C6H6 is refluxed with 5 cc. MeI 5-6 hrs., the sticky solid product dissolved in 20-5 cc. hot water and 2-3 cc. concentrated HCl, warmed 1 hr., extracted with Et2O, made alk. with 30% NaOH, and extracted with Et2O and then CHCl3. From the combined extracts on distillation in vacuo is obtained N-methyl-β-hydroxy-β-(p-methoxyphenyl)ethylamine (50 %); HCl salt, needles, m. 101° (Me2CO-EtOAc). From the corresponding cyanohydrins are prepared: β-hydroxy-β-(3,4-dimethoxyphenyl)ethylamine (72%), b4 180-2°; HCl salt (IV), m. 163°; its I derivative m. 129-30°; and N-methyl-β-hydroxy-β(3,4-dimethoxyphenyl)ethylamine (46%), HCl salt m. 143-5° (decomposition); also β-hydroxy-β-(3,4-methylenedioxyphenyl)ethylamine (80%), HCl salt m. 181-2°; its I derivative m. 155-6°; and N-methyl-β-hydroxy-β-(3,4-methylene-dioxyphenyl)ethylamine (50%), HCl salt m. 163-5° (decomposition). Homoveratroyl chloride (3 g.) is added to 2 g. IV in the min. amount of H2O, 1.5 g. KOH added, the mixture stirred vigorously 2 hrs., the yellow mass which separates washed with a little H2O, dissolved in the min. amount EtOH containing a few drops dilute NaOH, and allowed to stand 1 day to give 2 g. homoveratroyloxyhomoveratrylamine (V), m. 127-8° (C6H6). V (2 g.) refluxed in PhMe 5 min. with 10 g. P2O5, the PhMe decanted, the residue dissolved in ice H2O, the solution extracted with Et2O, the aqueous portion made alk. with concentrated NaOH, and the resulting emulsion kept 1 day gives 0.51 g. papaverine, m. 147° (CHCl3-petr. ether). Trans-cinnamoyl chloride (3 g.) in 15 cc. Et2O is added dropwise to 2 g. II in 50 cc. Et2O with vigorous stirring, the solution made alk. with dilute NaOH after a solid forms, and dl-trans-N-[β-hydroxy-β-(p-methoxyphenyl)]ethylcinnamide (VI) (1.2 g.), m. 177-8°, filtered, washed (H2O), and recrystallized from EtOAc. VI is identical with natural aegeline. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Electric Literature of 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Electric Literature of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Banerjee, Sunil Kumar; Chakravarti, R. N. published an article in 1965, the title of the article was Action of Raney nickel on egeline, egelone, and dihydro egeline.Recommanded Product: 456-12-2 And the article contains the following content:

cf. CA 52, 13672h. Egeline, p-MeOC6H4CH(OH)CH2NHCOCH:CHPh, was refluxed about 10 hrs. with Raney Ni in a p-cymene solution, filtered hot, and cooled to give needle crystals (I). I was dissolved in EtOH and chromatographed on Brockmann alumina to yield dihydroegelone, m. 126-7° (EtOH), identified by its semicarbazone, m. 139-40°. Following the same procedure, egelone and dihydroegeline were both converted into dihydroegelone. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Arthur, H. R.; Ng, Y. L. published an article in 1959, the title of the article was Examination of the rutaceae of Hong Kong. IV. Synthesis of dihydronitidine.Category: amides-buliding-blocks And the article contains the following content:

Dihydronitidine (I) was synthesized and the structures for nitidine (II) and oxynitidine (III) proposed in the earlier work confirmed. Acetopiperone (25 g.) and 30 g. veratraldehyde treated with 150 ml. alc. with 30 ml. 10% aqueous NaOH gave 30 g. 3,4-dimethoxy-3′,4′-methylenedioxychalcone (IV), m. 135° (alc.). IV (30 g.) in 110 ml. EtOCH2CH2OH containing 6.5 ml. AcOH treated 3 min. at 100° with 12.5 g. KCN in 45 ml. H2O, heating continued 10 min., 150 ml. H2O added, and the mixture cooled gave 30 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-α-oxobutyronitrile (V), yellow needles, m. 146° (alc.). V (30 g.) in 200 ml. AcOH treated gradually with 30 ml. concentrated H2SO4 gave 25 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-γ-oxobutyramide (VI), m. 177° (alc.). VI (25 g.) in 350 ml. 7% aqueous NaOH and 200 ml. alc. refluxed 10 hrs. and then acidified gave 22 g. α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-γ-oxobutyric acid (VII), needles, m. 172° (alc.). VII (11 g.) in 110 ml. AcOH containing 2 ml. 70% HClO4 hydrogenated during 2 hrs. at 60°/1 atm. over 2 g. 5% Pd-C, most of the solvent removed, H2O added, the oily product extracted with C6H6, the 8 g. brown oil [α-(3,4-dimethoxyphenyl)-γ-(3,4-methylenedioxyphenyl)-butyric acid] refluxed 4 min. with 20 ml. POCl3, the mixture poured on ice, the solid dissolved in CHCl3, washed with aqueous NaOH, H2O, dried, and evaporated gave 6.5 g. 2-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydro-6,7-methylenedioxy-1-oxonaphthalene (VIII), m. 165° (alc.). VIII(6 g.) in 15 ml. HCONH2 and 0.8 ml. HCO2H heated 3 hrs. at 180° with 0.8 g. (NH4)2SO4, 0.8 ml. HCO2H added hourly, the mixture cooled, diluted with H2O, extracted with CHCl3, washed, and evaporated gave 3.5 g. 2-(3,4-dimethoxyphenyl)-1-formamido-1,2,3,4-tetrahydro-6,7-methylenedioxynaphthalene (IX), m. 178° (dioxane-alc.). IX (1.5 g.) refluxed 15 min. with 3 ml. POCl3 in 10 ml. PhMe gave a solid which suspended in MeOH and basified gave 1 g. 3,4,11,12-tetrahydro-6,7-di-methoxy-2′,3′-methylenedioxy-1,2-benzophenanthridine (X), m. 188-9° (MeOH). X (0.9 g.) heated 0.5 hr. at 240° with 0.2 g. 30% Pd-C and extracted with CHCl3 gave 0.6 g. 6,7-dimethoxy-2′,3′-methylenedioxy-1,2-benzophenanthridine (XI), m. 273° (C5H5N). XI (0.5 g.) in 5 ml. xylene and 10 ml. PhNO2 refluxed a few min. with 1 ml. Me2SO4 gave the methosulfate of XI, m. 306-7° (decomposition) (aqueous alc.). XI methosulfate (0.4 g.) in 60 ml. H2O and 4 ml. concentrated HCl refluxed 5 hrs. with 8 g. Zn powder under argon, 3 ml. more HCl added after each hr., the solution cooled to 0-5°, sealed 12 hrs. under argon, the solid washed, shaken with CHCl3 and NH3, the extract washed, dried, and evaporated gave 0.2 g. I, prisms, m. 208-11° (alc.). Simple transformations used for I led to syntheses of II and III. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas:456-12-2) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics