Category: amides-buliding-blocks

Pawar, Rahul S.; Grundel, Erich published an article in 2017, the title of the article was Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).Related Products of 456-12-2 And the article contains the following content:

A review. The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act). The Dietary Supplement Health and Education Act of 1994 (DSHEA), which amended the FD&C Act, gave the FDA the authority to promulgate Good Manufacturing Practices for dietary supplements and required that manufacturers provide the FDA information supporting a conclusion that the ingredients are reasonably expected to be safe if the dietary ingredients were not marketed in the USA before 15 Oct. 1994. Recent amendments to the FD&C Act require that serious dietary-supplement-related adverse events be reported to the FDA and provide the agency with mandatory recall authority. We discuss the presence of naturally occurring (e.g. Ephedra, Citrus aurantium, Acacia) and synthetic (e.g. β-methylphenethylamines, methylsynephrine, α-ethyl-phenethylamine) biol. active phenethylamines (PEAs) in dietary supplements and of PEA drugs (e.g. clenbuterol, fenfluramine, sibutramine, lorcaserin) in weight-loss products. Regulatory actions against manufacturers of products labeled as dietary supplements that contain the aliphatic amines 1,3-dimethylamine and 1,3-dimethylbutylamine, and PEAs such as β-methylphenethylamine, aegeline, and Dendrobium illustrate the FDA’s use of its authority under the FD&C Act to promote dietary supplement safety. Published 2016. This article is a U. S. Government work and is in the public domain in the USA. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to phenethylamine dietary supplement regulation review, dshea, adulteration, dietary supplements, new dietary ingredient, phenethylamine, Food and Feed Chemistry: Reviews and other aspects.Related Products of 456-12-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Min; Jiang, Xingjun; Wang, Xueding; Zou, Hao; Yang, Weiqing; Zhang, Yuanyuan; Peng, Changrong; Li, Zicheng; Yang, Jing; Du, Quan; Ma, Menglin published an article in 2016, the title of the article was Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication.Name: 2-(4-Methylbenzamido)acetic acid And the article contains the following content:

A series of new arylpropenamide derivatives containing different aryl groups were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities. A new high accuracy QSAR model of arylpropenamide was constructed based on a more completely activities data and calculation parameter. The 2D-QSAR equations, by using DFT and multiple linear regression anal. methods, revealed that higher value of thermal energy (TE) and lower entropy Sn.1257 increase the anti-HBV activities of the arylpropenamide mols. Predictive 3D-QSAR models were established by SYBYL multifit mol. alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Name: 2-(4-Methylbenzamido)acetic acid

The Article related to aryl propenamide derivative preparation structure antiviral hepatitis b, 2d-qsar, 3d-qsar, sybyl, arylpropenamide, hepatitis b virus, Pharmacology: Structure-Activity and other aspects.Name: 2-(4-Methylbenzamido)acetic acid

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2015, Wang, Gang; Wang, Yutao; Wang, Lei; Han, Leiqiang; Hou, Xuben; Fu, Huansheng; Fang, Hao published an article.Product Details of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. And the article contained the following:

Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Product Details of 97-09-6

The Article related to imidazolidine dione derivative preparation bcl2 inhibitor antitumor leukemia, antitumor, bcl-2, imidazolidine-2,4-dione, inhibitors, Pharmacology: Structure-Activity and other aspects.Product Details of 97-09-6

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Amide – an overview | ScienceDirect Topics

On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:

The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6

The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6

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Amide – an overview | ScienceDirect Topics

Kim, Hye Jin; Seo, Young Ju; Htwe, Khin Myo; Yoon, Kee Dong published an article in 2021, the title of the article was Chemical constituents from Aegle marmelos fruits.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chem. structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle marmelos fruit chem constituent, Pharmaceuticals: Pharmacognostic Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2010, Caporossi, Lidia; De Rosa, Mariangela; Papaleo, Bruno published an article.Formula: C10H11NO3 The title of the article was Complete separation of urinary metabolites of xylene in HPLC/DAD using β-cyclodextrin: Application for biological monitoring. And the article contained the following:

To determine the biomarkers of exposure to xylene, urinary 2-, 3- and 4-methyl-hippuric acids, a new HPLC/DAD anal. method has been developed, which uses β-cyclodextrin as an additive for elution; its complexing abilities are exploited to achieve complete chromatog. separation of the three isomers. The mobile phase was a 3% aqueous solution of β-cyclodextrin, pH 3, and methanol, 80:20, in isocratic conditions, with a flow rate of 1 mL/min. To optimize quant. anal. three wavelengths were employed for detection: λ = 198 nm, λ = 200 nm, and λ = 202 nm. SPE was applied for the extraction from urine samples of analytes. Validation parameters show recoveries always above 82%; LOD was set at 1 μg/mL with an LOQ of 3 μg/mL. The linear dynamic range (from 4 to 100 μg/mL) showed excellent correspondence. This method is rapid and inexpensive and can be applied to several samples simultaneously using a manifold for SPE extraction The analytes were separated completely and could be fully quantified. The method was used for the anal. of urine samples from 54 workers exposed to xylene in hospital laboratories and showed a good applicability while allowing quantification even at low doses. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to xylene occupational exposure methylhippuric acid biomarker urine analysis, methylhippuric acid urine analysis hplc cyclodextrin, Toxicology: Methods (Including Analysis) and other aspects.Formula: C10H11NO3

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Amide – an overview | ScienceDirect Topics

On December 15, 2017, Gonzalez, Johannes L.; Pell, Albert; Lopez-Mesas, Montserrat; Valiente, Manuel published an article.HPLC of Formula: 27115-50-0 The title of the article was Simultaneous determination of BTEX and their metabolites using solid-phase microextraction followed by HPLC or GC/MS: An application in teeth as environmental biomarkers. And the article contained the following:

Applications of benzene, toluene, ethylbenzene, and o-, m-, and p-xylenes (BTEX) release them into the environment exposing living organism. These endocrine disruptors are toxic, highly volatile and easily absorbed by the lungs and can cause adverse consequences for the human health as neurol. diseases and cancer. A method for the anal. of BTEX and its metabolites (phenols and aromatic acids) in teeth is presented. The method consists in a one-step simple extraction procedure from spiked tooth using NaOH solution followed by SPME-HPLC or HS-SPME-GC/MS determination Optimization of both, spiking procedure and extraction step of these analytes from tooth, was carried out. Two fibers CAR/PDMS for BTEX and PA for BTEX metabolites were used for the SPME and variables were optimized for analytes at 30° using spiked solutions The optimized adsorption times were 30, 75 and 30 min and desorption times were 10, 40 and 30 min for BTEX, phenols and aromatic acids, resp. Linearity for SPME-HPLC method was established using spiked solutions with both, BTEX and metabolites, at 2.5, 5.0, 10.0, 25.0 μg/mL. The obtained results indicated a good linearity (R2 above 0.994) for all analytes. Triplicate analyses were performed with RSD lower than 15%. LODs were in the range 0.2-33.3 ng/mL for SPME-HPLC and 0.06-0.09 pg/mL for HS-SPME-GC/MS methods in spiking solutions Once the method was optimized, bovine teeth were used as biol. matrix model for the tuning of spiking and extraction steps. Optimal adsorption and desorption times were 4 h for both procedures. Micrograms per tooth gram of BTEX and phenols were quantified in ten human teeth and aromatic acids were not identified. The developed method for BTEX and metabolites analyses using SPME-HPLC or HS-SPME-GC/MS shows good precision, linearity and sensitivity. The method was successfully applied in human teeth as environmental biomarker of BTEX and metabolites. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to btex metabolite biomarker determination tooth hplc gc ms, btex, btex metabolites, hplc, gc–ms, human teeth samples, spme, Toxicology: Methods (Including Analysis) and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Toda, Yasunori; Tanaka, Katsumi; Matsuda, Riki; Suga, Hiroyuki published an article in 2019, the title of the article was Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts.Related Products of 5455-98-1 And the article contains the following content:

Preparation of vicinal halohydrins by the ring-opening reaction of epoxides under visible-light conditions using copper or iron chlorides catalyst was described. The use of trichloroacetonitrile as a chloride source enabled catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to epoxide trichloroacetonitrile metal chloride catalyst regioselective photochem ring opening, chlorohydrin preparation, Aliphatic Compounds: Alcohols and Thiols and other aspects.Related Products of 5455-98-1

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2021, Toffa, Joelle; Loko, Yeyinou Laura Estelle; Djedatin, Gustave; Gbemavo, Charlemagne D. S. J.; Orobiyi, Azize; Tchakpa, Cyrille; Ewedje, Eben-Ezer; Sabot, Francois published an article.HPLC of Formula: 79-07-2 The title of the article was Rice pests in the Republic of Benin : farmers’ perceptions, knowledge and management practices. And the article contained the following:

Rice (Oryza spp) is one of the most consumed cereals in the Republic of Benin. However, rice production is threatened by various pests, which lead to important yield losses. For the development of integrated management strategies responding to the farmers’ realities, it is important to document their perceptions, knowledge and management of rice pests. Surveys involving 418 rice farmers to 21 ethnic groups through 39 villages were performed using rural appraisal tools. Farmers perceived birds, specifically weavers as the most important rice pests. The surveyed farmers also identified the variegated grasshopper, Zonocerus variegatus L. and rice brown leaf spots [Curvularia lunata (Wakker) Boedijn] as the main pests in the northern region, the pink stem borer, Sesamia calamistis Hampson and rice blast (Magnaporthe grisea (Hebert) Barr) in the southern region, and Z. variegatus and rice yellow mottle virus (genus Sobemovirus) in central Benin. The most important rice storage constraint was rodent attacks and the surveyed farmers proposed 13 key solutions to minimize constraints related to rice storage. Among various pest control methods recorded, farmers used mainly synthetic chem. pesticides. However, the Beninese National Pesticide Management Committee (CNGP) does not recommend most of pesticides used by farmers for rice protection (prohibited pesticides or intended for the protection of other crops). Farming experience, family size, region and number of observed pests have significantly influenced farmers’ decision to use pesticides. The rice pests perceived by farmers as important vary significantly across regions. These results suggest that integrated pest management programs which target rice pests accounting for these regional differences will be more effective. The identified variables that influence the use of pesticides must be taken in account in the development of strategies which will encourage farmers to use ecofriendly pest management. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).HPLC of Formula: 79-07-2

The Article related to farmer rice pest management practice, birds, diseases, insect pests, pesticides, rodents, traditional control, weeds, Agrochemical Bioregulators: Invertebrate and other aspects.HPLC of Formula: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2019, Cook, Daniel W.; Oram, Kelson G.; Rutan, Sarah C.; Stoll, Dwight R. published an article.Recommanded Product: 27115-50-0 The title of the article was Rational design of mixtures for chromatographic peak tracking applications via multivariate selectivity. And the article contained the following:

Chromatog. characterization and parameterization studies targeting many solutes require the judicious choice of operating conditions to minimize anal. time without compromising the accuracy of the results. To minimize anal. time, solutes are often grouped into a small number of mixtures; however, this increases the risk of peak overlap. While multivariate curve resolution methods are often able to resolve analyte signals based on their spectral qualities, these methods require that the chromatog. overlapped compounds have dissimilar spectra. In this work, a strategy for grouping compounds into sample mixtures containing solutes with distinct spectral and, optionally, with distinct chromatog. properties, in order to ensure successful solute resolution either chromatog. or with curve resolution methods is proposed. We name this strategy rational design of mixtures (RDM). RDM utilizes multivariate selectivity as a metric for making decisions regarding group membership (i.e., whether to add a particular solute to a particular sample). A group of 97 solutes was used to demonstrate this strategy. Utilizing both estimated chromatog. properties and measured spectra to group these 97 analytes, only 12 groups were required to avoid a situation where two or more solutes in the same group could not be resolved either chromatog. (i.e., they have significantly different retention times) or spectrally (i.e., spectra are different enough to enable resolution by curve resolution methods). When only spectral properties were utilized (i.e., the chromatog. properties are unknown ahead of time) the number of groups required to avoid unresolvable overlaps increased to 20. The grouping strategy developed here will improve the time and instrument efficiency of studies that aim to obtain retention data for solutes as a function of operating conditions, whether for method development or determination of the chromatog. parameters of solutes of interest (e.g., kw). The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 27115-50-0

The Article related to analyte adsorption chromatog spectra, multivariate curve resolution, net analyte signal, rational design of mixtures, Organic Analytical Chemistry: Detections and other aspects.Recommanded Product: 27115-50-0

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics