Category: amides-buliding-blocks

On July 25, 2013, Popovici-Muller, Janeta; Saunders, Jeffrey O.; Salituro, Francesco G.; Cai, Zhenwei; Yan, Shunqi; Zhou, Ding published a patent.HPLC of Formula: 16230-24-3 The title of the patent was Preparation of heterocycles as isocitrate dehydrogenase 1 inhibitors, therapeutically active compositions and their methods of use. And the patent contained the following:

Provided are compounds of formula I as IDH1 inhibitors; their preparation and use of those compounds for treating cancer. Compounds of formula I wherein R1 is (un)substituted C4-6 carbocyclyl; R2 and R3 are independently (un)substituted aryl and (un)substituted heteroaryl; R4 is (un)substituted saturated heterocyclyl, heteroaralkyl, CH2-heterocyclyl, etc.; and pharmaceutically acceptable salts and hydrates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their IDH1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 0.1 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).HPLC of Formula: 16230-24-3

The Article related to heterocycle preparation idh1 inhibitor treatment cancer, Heterocyclic Compounds (One Hetero Atom): Other 5-Membered Rings and other aspects.HPLC of Formula: 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yao, Wubing; Yang, Jianguo; Hao, Feiyue published an article in 2020, the title of the article was Ru-Catalyzed Selective C(sp3)-H Monoborylation of Amides and Esters.Reference of N,N-Diethylacetamide And the article contains the following content:

A ruthenium-catalyzed method has been developed for the C(sp3)-H monoborylation of various unactivated alkyl and aryl amides and challenging esters, with a low-cost and bench-stable boron source, providing boronates with exclusive selectivity, high efficiency, and high turnover number (up to 8900). This novel strategy may offer a versatile and environmentally friendly alternative to current methods for selective C(sp3)-H borylation that employ even more expensive metals, such as iridium and rhodium. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to green chem ruthenium catalyst selective borylation amide ester, boronic ester preparation green chem, c−h activation, amides, borylation, ester, ruthenium, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 12, 2022, Dannatt, Jonathan E.; Yadav, Anshu; Smith, Milton R. III; Maleczka, Robert E. Jr. published an article.Application of 685-91-6 The title of the article was Amide directed iridium C(sp3)-H borylation catalysis with high N-methyl selectivity. And the article contained the following:

A bidentate monoanionic ligand system was developed to enable iridium catalyzed C(sp3)-H activation borylation of N-Me amides. Borylated amides were obtained in moderate to good isolated yields, and exclusive mono-borylation allowed the amide to be the limiting reagent. Selectivity for C(sp3)-H activation was demonstrated in the presence of sterically available C(sp3)-H bonds. Competitive kinetic isotope studies revealed a large primary isotope effect, implicating C-H activation as the rate limiting step. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to amide directing group iridium catalyst borylation selective bond activation, boronic ester preparation selective, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Narender, T.; Rajendar, K.; Sarkar, S.; Singh, V. K.; Chaturvedi, Upma; Khanna, A. K.; Bhatia, G. published an article in 2011, the title of the article was Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity.SDS of cas: 456-12-2 And the article contains the following content:

In continuation of a program on metabolic diseases, the alkaloidal amide aegeline (I) from Aegle marmelos leaves was identified as a dual acting agent (antihyperlipidemic and antihyperglycemic). Therefore, a series of alkaloidal amides [N-(2-hydroxy-2-p-tolylethyl)-amides and N-(2-oxo-2-p-tolylethyl)-amide derivatives] related to aegeline was synthesized and screened in vivo in rats for antihyperlipidemic activity in Triton induced hyperlipidemia model. The synthetic compounds II, (E)-Me-4-C6H4CH(OH)CH2NHCOCH:CHC6H3-4-OH-3-OMe and Me-4-C6H4CH(OH)CH2NHCOCH2R (R = 3-pyridinyl) showed equipotent activity to the natural product, i.e., aegeline. These compounds also showed strong antioxidant activity, which support their antihyperlipidemic activity. Me-4-C6H4COCH2NHCO(CH2)2R (R = 3-pyridinyl) showed better antihyperlipidemic and antioxidant profile than the natural product I. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).SDS of cas: 456-12-2

The Article related to aegeline alkaloid amide derivative synthesis antihyperglycemic antidyslipidemic antioxidant activity, Alkaloids: Alkaloids Containing One Nitrogen Atom Not In A Ring and other aspects.SDS of cas: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2018, Zhang, Yinsheng; Gao, Yong; Ren, Jing; Wang, Qinglin; Zhao, Damin; Zhou, Yu; Wu, Zheyang published a patent.Synthetic Route of 16230-24-3 The title of the patent was Preparation of boron-containing compounds as tyrosine kinase inhibitors. And the patent contained the following:

The title compounds I [wherein R1 is H, F, Cl, Br, alkyl, etc.; X is NH or O; R4 and R6 are independently H, alkyl, alkoxy, etc.; R3 and R7 are independently H and alkoxy; R5 is H, alkylamino, alkyl, cycloalkyl, etc.; Cy is (un)substituted Ph] were claimed and prepared The inventive compound has good inhibitory action on tyrosine kinase, and can be applied in treating the proliferative diseases caused by tyrosine kinase. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Synthetic Route of 16230-24-3

The Article related to preparation boron tyrosine kinase inhibitor treatment proliferative disease, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Synthetic Route of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2011, Nugroho, Agung Endro; Riyanto, Sugeng; Sukari, Mohamad Aspollah; Maeyama, Kazutaka published an article.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Effects of aegeline, a main alkaloid of Aegle marmelos correa leaves, on the histamine release from mast cells. And the article contained the following:

Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on the histamine release from mast cell. The study was performed by using (1) rat basophilic leukemia (RBL-2H3) cell line, and (2) rat peritoneal mast cells (RPMCs). DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine release from mast cell. In our study, aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP24-BSA. Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca2+ stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca2+ pool only since could not inhibit the 45Ca2+ influx into RBL-2H3 cells. Aegeline showed weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. These findings indicate that aegeline altered the signaling pathway related to the intracellular Ca2+ pool in which thapsigargin acts. Based on the results, the inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca2+ signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca2+ signaling in mast cells. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to antihistamine aegeline alkaloid aegle leaf histamine release mast cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 1, 2022, Dabrowska, Aleksandra M.; Mech-Warda, Paulina; Wera, Michal; Domzalska, Marta; Makowski, Mariusz; Chylewska, Agnieszka published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Prototropic tautomerism of (E)-N-((4-((2-hydroxy-5-methoxybenzylidene) amino)phenyl)sulfonyl)acetamide and its coordination abilities towards Ru, Rh, and Ir trivalent metal ions. And the article contained the following:

The Schiff base (E)-N-((4-((2-hydroxy-5-methoxybenzylidene)amino)phenyl)sulfonyl) acetamide (ScB-SAM) has been synthesized bytheir condensation at room temperature in ethanol. X-ray crystallog. anal. revealed that the keto-enol tautomerism of its solid state exists as a complex equilibrium system that is stabilized intramol. hydrogen bond. The enol, keto and mixed enol-zwitterionic forms were observed in the crystal structure. The crystallog. results were supported by ATR, and UV-Vis. Phys. properties were determined in different polar and nonpolar solvents and solid state. All above exptl. results were then compared with DFT calculations Addnl., the stabilities of the trivalent: iridium, rhodium and ruthenium ions complexes with ScB-SAM have also been investigated by spectrophotometric titration methods in water. The data showed that the examined coordination compounds were stable in solution based on the values of their stability constants found. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to salicylideneaniline schiff base preparation electronic structure metal coordination stability, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Chuhui; Maness, J. Clark; Cuthbertson, Amy A.; Kimura, Susana Y.; Liberatore, Hannah K.; Richardson, Susan D.; Stanford, Benjamin D.; Sun, Mei; Knappe, Detlef R. U. published an article in 2020, the title of the article was Treating water containing elevated bromide and iodide levels with granular activated carbon and free chlorine: impacts on disinfection byproduct formation and calculated toxicity.Electric Literature of 79-07-2 And the article contains the following content:

We evaluated the efficacy of granular activated carbon (GAC) adsorption for mitigating formation of chlorine disinfection byproducts (DBPs) in water with a wide range of bromide (20-1000μg L-1) and iodide (<5-100μg L-1) concentrations GAC effectiveness was assessed by determining speciated total organic halogen (TOX), 70 DBPs, and calculated cyto- and genotoxicity. Overall, GAC treatment effectively lowered formation of TOX and the majority of targeted DBPs over the evaluated service time (>30 000 bed volumes). In the GAC influent, total organic bromine increased from 10 to 84% of TOX as bromide levels increased from 20 to 1000μg L-1. Dissolved organic carbon (DOC) removal by GAC increased the bromide-to-DOC (Br/DOC) concentration ratio in GAC effluent relative to influent. As a result, bromine incorporation into DBPs increased after GAC treatment, especially at early GAC service times and low bromide levels. Total organic iodine was <3.5% of TOX, and iodo-DBP formation was low because elevated iodide was only evaluated in the presence of high bromide and free chlorine, a scenario that favors iodate formation. Although trihalomethanes (THMs) and haloacetic acids (HAAs) consistently formed at the highest molar concentrations, they were not major contributors to calculated cyto- and genotoxicity. Principal contributors to calculated cytotoxicity included haloacetaldehydes (HALs), haloacetamides (HAMs), and haloacetonitriles (HANs), while the main drivers of genotoxicity were HALs, HAMs, HANs, and halonitromethanes (HNMs) despite lower concentrations Because bromine incorporation into DBPs increased nonlinearly with increasing Br/DOC concentration ratios, GAC more effectively controlled calculated toxicity at elevated bromide levels. Calculated cyto- and genotoxicity did not vary strongly with GAC service life, suggesting that GAC treatment can effectively lower calculated toxicity over long periods of operation. The majority of TOX remained unknown (>50%) in all samples despite the quantification of 70 DBPs targeted in this study, highlighting the need to assess toxicity associated with unknown DBPs. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Electric Literature of 79-07-2

The Article related to bromide iodide activated carbon chlorine disinfection byproduct formation toxicity, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.Electric Literature of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nayaka, Swapna r.; Sabari, Anand j. v.; Shareef, Shaik mabu; Usha, N. s. published an article in 2020, the title of the article was Gas chromatography-mass spectroscopy [Gc-Ms] analysis and phytochemical screening for bioactive compounds in Caulerpapeltata(Greenalga).COA of Formula: C6H13NO And the article contains the following content:

Seaweeds (Marine macroalgae) area large group of marine organisms containing important phytochem. constituents with various biol. activities. They are potentially prolific sources of highly bioactivese condary metabolites, which manifest many of the rapeutic effects like anti-cancer, anti-oxidant, anti-inflammatory and anti-diabetic activities. Seaweeds are used by many Asian cultures for traditional medicine preparations The Caulerpapeltata was collected from Rameshwaram coastal area it was shade dried, made in to powder using standardized procedure to get Caulerpa peltata Methanolic Extract (CPME). The phytochems. and Gas Chromatog.-Mass Spectrometry (GC-MS) anal. was done on prepared CPME for identifying the bioactive compounds Phytochem. in vestigation suggests that the Caulerpa peltata exhibited the presence of phytochems. like Alkaloids, Carbohydrates, Phytosterols, Saponins and Diterpenes, which may contribute to its biol. activities. GC-MS anal. showed 28 variety of compounds, among which Dibutylphthalate, n-hexadecanoic acid, and 1,2-Benzenedic arboxylic acid was found in high percentage. The phytochem. studies and the compounds available in GC-MS showed that the Caulerpapeltata contain important bio active compounds, which may have anti-microbial, anti-fungal and anti-canceractivity. Further research is needed for finding its use in development of new pharmaceutical agent and its safe consumption by human for various health benefits. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).COA of Formula: C6H13NO

The Article related to cauler papeltata bioactive compound phytochem gas chromatog mass spectroscopy, Microbial, Algal, and Fungal Biochemistry: Composition and Products and other aspects.COA of Formula: C6H13NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 25, 2007, Yu, Xuhui; Ge, Hongyan; Zhang, Lei; Song, Han; Yu, Ying; Wang, Yuhong published an article.Synthetic Route of 456-12-2 The title of the article was Expressions of IL-12 and IL-18 in patients with acute optic neuritis before and after methylprednisolone pulse therapy. And the article contained the following:

The expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) and the relationship between IL-12 and IL-18 in acute optic neuritis (AON) before and after methylprednisolone pulse therapy (MPPT) were investigated. ELISA was employed to determine the expressions of IL-12 and IL-18 in serum in 27 patients with AON before and after MPPT. RT-PCR anal. was employed to demonstrate the expressions of IL-12 and IL-18 receptors in peripheral lymphocytes. The serum level of IL-12 was decreased from (45.6±12.2) ng/L to (17.1±4.7) ng/L after MPPT (P < 0.01), and that of IL-18 was decreased from (157.5±39.3) ng/L to (126.2±22.6) ng/L (P < 0.05). The expression of IL12R mRNA was decreased after MPPT too (0.2948 vs. 0.1507, P < 0.05), and so was that of IL18R mRNA (0.5352 vs. 0.2843, P < 0.05). The expressions of IL-12 and IL-18 as well as those of their receptors were pos. correlated. Methylprednisolone could exert its important antiphlogistic action against AON by inhibiting the expressions of the proinflammatory cytokines, IL-2 and IL-18. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Synthetic Route of 456-12-2

The Article related to interleukin il12 il18 optic neuritis methylprednisolone antiinflammatory, Mammalian Hormones: Corticosteroid, Gonadal, and Placental Hormones and other aspects.Synthetic Route of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics