Category: amides-buliding-blocks

On February 1, 2021, Ikeda, Yuko; Matsukawa, Yuko; Yonekura, Kyohei; Shirakawa, Eiji published an article.Electric Literature of 685-91-6 The title of the article was Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism. And the article contained the following:

In the presence of a substoichiometric amount of a tert-butoxy radical precursor and a base, alkylamides were found to be heteroarylated at their α-C-H bonds with sulfonylheteroarenes through homolytic aromatic substitution, where a radical chain is operative. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to amidoalkylation sulfonylheteroarene alkylamide radical chain preparation, amides role: rct (reactant), ract (reactant or reagent), amidoalkylation, radical reaction mechanism and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sahoo, Basudev; Surkus, Annette-Enrica; Pohl, Marga-Martina; Radnik, Joerg; Schneider, Matthias; Bachmann, Stephan; Scalone, Michelangelo; Junge, Kathrin; Beller, Matthias published an article in 2017, the title of the article was A Biomass-Derived Non-Noble Cobalt Catalyst for Selective Hydrodehalogenation of Alkyl and (Hetero)Aryl Halides.Recommanded Product: N,N-Diethylacetamide And the article contains the following content:

Hydrodehalogenation is a straightforward approach for detoxifications of harmful anthropogenic organohalide-based pollutants, as well as removal of halide protecting groups used in multistep syntheses. A novel sustainable catalytic material was prepared from biowaste (chitosan) in combination with an earth-abundant cobalt salt. The heterogeneous catalyst was fully characterized by transmission electron microscope, X-ray diffraction, and XPS measurements, and successfully applied to hydrodehalogenation of alkyl and (hetero)aryl halides with broad scope (>40 examples) and excellent chemoselectivity using mol. hydrogen as a reductant. The general usefulness of this method is demonstrated by successful detoxification of non-degradable pesticides and fire retardants. Moreover, the potential of the catalyst as a deprotection tool is demonstrated in a multistep synthesis of (±)-peronatin B (alkaloid). The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to chitosan cobalt oxide catalyst hydrodehalogenation organohalide pollutant, chitosan, cobalt, hydrodehalogenation, hydrogen, non-noble metals, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Madej, Dominik; Konopko, Adrian; Piotrowski, Piotr; Krogul-Sobczak, Agnieszka published an article in 2020, the title of the article was Pd nanoparticles and mixture of CO2/CO/O2 applied in the carbonylation of aniline.Related Products of 102-07-8 And the article contains the following content:

CO2 is a compound of high stability which proves useful in some organic syntheses as a solvent or component decreasing explosivity of gases. It is also a good carbonylating agent for aliphatic amines although not for aromatic ones, the latter being carbonylated with phosgene or, as in our previous works, with CO/O2 in the presence of Pd(II) complexes. In this work we have used the mixture of CO/O2 and CO2 for carbonylation of aniline to N,N’-diphenylurea. After optimization of the reaction conditions (56% of CO2 in CO2/CO mixture) we studied the activity of three kinds of pre-catalysts: (a) Pd(II) complexes, (b) Pdblack, and (c) palladium nanoparticles (PdNPs) in the presence of derivatives of pyridine (XnPy). The highest conversion of aniline (with selectivity towards N,N-diphenylurea ca. 90%) was observed for PdNPs. The results show that catalytic cycle involves Pd(0) stabilized by pyridine ligand as active species. Basing on this observation, we put the hypothesis that application of PdNPs instead of Pd(II) complex can efficiently reduce the reaction time. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to palladium nanoparticle carbon dioxide monoxide oxygen aniline carbonylation, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2020, Zhang, Hui; Cui, Xiaojing; Wang, Hongliang; Wang, Yuqi; Zhao, Yuhua; Ma, Hui; Chai, Lin; Wang, Yingxiong; Hou, Xianglin; Deng, Tiansheng published an article.Reference of 1,3-Diphenylurea The title of the article was Degradation of polycarbonate-based polyurethane via selective cleavage of carbamate and urea bonds. And the article contained the following:

Deep eutectic solvents (DESs) have attracted broad attention due to their low cost and toxicity, easy preparation, good biol. compatibility and similar characteristics to those of ionic liquids In this study, a DES system composed of choline chloride and urea has been applied for the controllable degradation of polyurethane (PU). By the combination of Fourier transform IR spectroscopy (FT-IR), NMR spectroscopy (NMR) and matrix-assisted laser anal. ionization time-of-flight mass spectrometer (MALDI-TOF-MS), the selective cleavage of carbamate and urea bonds with little damage on carbonate bonds was achieved in the DES system by the regulation of reaction conditions, which favored the recovery of both valuable polycarbonate diol (PCDL) and 3,3′-Dimethyl-[1,1′-biphenyl]-4,4′-Diamine (o-toluidine). The degradation rate of PU and the yield of PCDL reached 100% and 57.4% resp. under mild conditions (1 atm, 170°C, 8 h). A possible degradation mechanism was proposed based on the exptl. results, in which the synergistic effect of choline chloride and urea activated largely the carbamate bond and thus led to a controlled degradation of PU. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to polycarbonate urethane rubber degradation deep eutectic solvent, Synthetic Elastomers and Natural Rubber: Chemical Properties Of Elastomers and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2018, Vallejos Calzada, Saul; Garcia Garcia, Felix Clemente; Serna Arenas, Felipe; Camara Nebreda, Jose Maria; Represa Perez, Cesar; Bertolin Burillo, Juan Carlos; Garcia Perez, Jose Miguel; Pascual Portal, Blanca Sol; Trigo Lopez, Miriam published a patent.Recommanded Product: N-(3-Aminophenyl)acrylamide The title of the patent was Conductive polymers based on polyaniline sequences and procedure for obtaining them. And the patent contained the following:

The invention relates to solid elec. conductive polymeric materials prepared by growing polyaniline side chains from non-conducting polymers with aminophenyl side groups in their structure, preferably in form of films or coatings, as well as the procedure for obtaining them and their use in the elaboration of sensors with resistive or conductive substances for substances of interest, both in the gas phase and in the dissolution, or for use in elec. and electronic systems. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: N-(3-Aminophenyl)acrylamide

The Article related to conductive polymer polyaniline, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Recommanded Product: N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2017, Topkaya, Derya; Alp, Serap published an article.HPLC of Formula: 27115-50-0 The title of the article was New Chromophore Systems from Coumarin-Oxazol-5-one Combination. And the article contained the following:

Coumarin-oxazol-5-one (COX), I [Ar = C6H5, naphthalen-1-yl, 4-O2NC6H4, 4-H3CC6H4], were synthesized with 7-methoxy-2-oxo-2H-chromene-4-carbaldehyde and benzoylglycine derivatives ArC(O)NHCH2C(O)OH. The characterizations of the COX derivatives I by 1H NMR, FT-IR and elemental anal. were achieved. The photophys. data of the synthesized COX derivatives I were obtained using spectrophotometric and spectrofluorimetric methods. Evaluation of the absorption and emission properties of the structures was carried out in different solvents. Maximum absorption and emission wavelengths (λ; nm), molar extinction coefficients (ε; cm-1 M-1), Stoke’s shifts (ΔλST; nm) and quantum yields (ΦF) of the COX derivatives I were declared. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).HPLC of Formula: 27115-50-0

The Article related to coumarin oxazolone preparation diastereoselective, aroyl glycine methoxy oxo chromene carbaldehyde heterocyclization, chromophore, coumarin, oxazol-5-one, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.HPLC of Formula: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2018, Fadavi, Abdulhamid; Zarei, Maaroof published an article.Related Products of 27115-50-0 The title of the article was One-pot Vilsmeier reagent-mediated multicomponent reaction: A direct synthesis of oxazolones and Erlenmeyer azlactones from carboxylic acids. And the article contained the following:

N-Acylation of glycine with carboxylic acids RC(O)OH [R = C6H5, 4-pyridyl, 2-naphthyl, CH3CH=CH, etc.] was carried out by using the Vilsmeier reagent. The resulting N-acyl-α-amino acids RC(O)NHCH2C(O)OH were subsequently cyclodehydrated into oxazol-5-ones I via the Vilsmeier reagent. Finally, treatment of oxazol-5-ones I with aldehydes R1CHO [R1 = CH3, C6H5, 2-furyl, etc.] in the presence of the Vilsmeier reagent delivered Erlenmeyer azlactones II. By combining these steps, using the Vilsmeier reagent allowed direct one-pot conversion of carboxylic acids RC(O)OH into oxazol-5-ones I and direct one-pot conversion of carboxylic acids RC(O)OH into Erlenmeyer azlactones in the presence of aldehydes R1CHO. These Vilsmeier reagent-mediated multicomponent reactions proceeded smoothly in reasonable chem. yields at room temperature The chem. structure of the title compounds I and II was confirmed by spectral data. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to azlactone preparation, carboxylic acid glycine aldehyde vilsmeier multicomponent, oxazolone preparation, glycine carboxylic acid vilsmeier multicomponent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Related Products of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 17, 2018, Na, Yun Soo; Bang, Keuk Chan; Park, Joon Seok published a patent.Product Details of 16230-24-3 The title of the patent was Preparation of novel pyrrolopyrimidine derivatives as BTK inhibitors and pharmaceutical composition comprising the same. And the patent contained the following:

The invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, and the compound according to the invention can be usefully used for the prevention or treatment of diseases in which the BTK inhibitory action is beneficial. Compounds of formula I wherein X is NH and O; L is a bod and CO; R is H, (un)substituted C6-10 aryl and (un)substituted C3-10 heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 20.9 n< and 100 % inhibition at 1 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Product Details of 16230-24-3

The Article related to pyrrolopyrimidine preparation btk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nishida, K.; Ohtsu, T.; Tanaka, S.; Miyatake, M.; Hotsuta, T.; Iwamoto, H. published an article in 1973, the title of the article was Preparation of 2-nitro-N,N-dimethylaniline-4-sulfon-N-alkylamides and their dyeing properties on synthetic polymer fibers.Recommanded Product: 97-09-6 And the article contains the following content:

Disperse dyes (I, R = H, Me, Et, Pr, Bu, pentyl) were prepared and the substantivity of I on polyamide, cellulose acetate, acrylic, and polyester fibers increased with increasing chain length of R. In general, bright yellow dyeings were obtained, the brightest on cellulose acetate, with good fastness properties except for poor light-fastness. The amount of dye transferred in heat-transfer printing decreased as the chain length of R increased. Thus, 4,3-Cl(O2N)C6H3SO2Cl was treated with RNH2, the intermediate 4,3-Cl(O2N)C6H3SO2NHR treated with NMe2 to give I. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

The Article related to nitro disperse dye, substantivity nitro dye, Dyes, Fluorescent Whitening Agents, and Photosensitizers: Nitroso and Nitro Dyes and other aspects.Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 14, 2014, Haq, Nadia; Niu, Deqiang; Petter, Russell C.; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong published a patent.Quality Control of N-(3-Aminophenyl)acrylamide The title of the patent was Pyrimidine derivatives as ERK inhibitors and their preparation. And the patent contained the following:

The invention provides compounds of formula I, compositions thereof, and methods of using the same. Compounds of formula I wherein A is (un)substituted Ph, 3- to 8-membered (un)saturated monocyclic ring, 4- to 7-membered monocyclic heterocyclic ring, etc.; B is (un)substituted Ph, (un)substituted (un)saturated 3- to 7-membered carbocyclic ring, 5- to 6-membered monocyclic heteroaryl, absent, etc.; m and p are independently 0 – 4; R1 is a warhead group, wherein R1 is attached to an atom adjacent to where W is attached; each R2 is H, (un)substituted C1-6 aliphatic, halo and OH and derivatives; each R3 is H, halo, OH and derivatives, SH and derivatives, CN, etc.; R4 is H, (un)substituted C1-6 aliphatic, halo, haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their ERK inhibitor activity (some data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide

The Article related to pyrimidine preparation erk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics