Category: amides-buliding-blocks

On December 17, 2021, Arisawa, Mieko; Mizuno, Taro; Nozawa-Kumada, Kanako; Itto-Nakama, Kaori; Furuta, Miyu; Tanii, Saori published an article.Application of 102-07-8 The title of the article was Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift. And the article contained the following:

Unsym. di(heteroaryl)ureas such as Ar1NHC(O)NHAr2 [Ar1 = pyrimidin-2-yl, 4-methoxyphenyl, 4,6-dimethylpyrimidin-2-yl, etc.; Ar2 = Ph, 4-pyridyl, 4-methoxy-2-pyridyl, etc.] were efficiently synthesized from two sym. ureas, Ar1NHC(O)NHAr1 and Ar2NHC(O)NHAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions could be shifted to the formation of unsym. ureas by the aggregation of the dimers formed by inter- and intramol. hydrogen bonding. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to di heteroaryl urea preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2021, Brown, Trevor N. published an article.Recommanded Product: 685-91-6 The title of the article was Empirical regressions between system parameters and solute descriptors of polyparameter linear free energy relationships (PPLFERs) for predicting solvent-air partitioning. And the article contained the following:

Polyparameter Linear Free Energy Relationships (PPLFERs) are an empirical tool used to predict the equilibrium partitioning of solutes between two phases, referred to as a system. There are exptl. determined solute descriptors for thousands of chems., but there are only on the order of 100 systems with calibrated system parameters, the majority of which are solvents and environmental matrixes in equilibrium with air or water. The goal of this work is to create empirical regressions which use the much more numerous solute descriptors to predict the system parameters of systems which have not yet been calibrated due to a lack of partitioning data. The special case of liquid solvents in equilibrium with air is the focus of this work because this is the case in which the relationship between solute and solvent properties is most clear. First a consistent dataset of PPLFER equations was compiled using partition coefficient data from the literature to recalibrate equations for solvent-air partitioning into the Goss form (Goss, K.-U. 2005) for 89 solvents including water. All 89 solvents have also solute descriptors available in a database curated for this work which describe their behavior as solutes. The pool of descriptors drawn from to create the empirical regressions were the solute descriptors of the solvents normalized to McGowan volume (V), along with interaction parameters between the normalized descriptors. An applicability domain (AD) for the empirical regressions was defined using leverage to measure similarity to the training dataset of solvents, and solvents in the AD typically had lower RMSE for predictions. Some of the empirical regressions for the six system parameters have good predictive power (s, a, b, c) while others are only adequate (v, l). However, when these equations are combined to predict partition coefficients there is a significant cancellation of error and when predicting partition coefficients in an external validation dataset the RMSE is in the range 0.30-0.35. The empirical regressions combined with the PPLFER equations and solvent d. can also be used to predict vapor pressures as an addnl. external validation. Predictions for a dataset of vapor pressures from the literature had an RMSE of 0.26-0.75. Analyzing and comparing the results from these two external validation datasets the RMSE for predicting datasets of partition coefficients for arbitrary solutes in arbitrary systems of solvents in equilibrium with air is estimated to be 0.66 on average The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to solvent air partitioning regression system parameter solute descriptor pplfer, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Canner, Adam J.; Harwood, Laurence M.; Cowell, Joseph; Babra, Jasraj S.; Brown, Solomon F.; Ogden, Mark D. published an article.SDS of cas: 685-91-6 The title of the article was Spectrophotometric Analysis of Ternary Uranyl Systems to Replace Tri-N-butyl Phosphate (TBP) in Used Fuel Reprocessing. And the article contained the following:

In this report, the interaction of monoamide/diamide and monoamide/diglycolamide mixtures with UO2+2 are investigated in pH = 1 methanolic nitric acid media. These monoamides include N,N-dimethylacetamide (DMAA), N,N-diethylacetamide (DEAA), N,N-dibutylacetamide (DBAA) and N,N-dibutylbutanamide (DBBA). N,N,N’N’-tetraethylmalonamide (TEMA) and N,N,N’,N’-tetraethyldiglycolamide (TEDGA), which were chosen as model diamides and diglycolamides, resp. Complex stability constants for each ligand were modeled using the Stability Quotients Using Absorbance Data program using UV-visible data. Complex stoichiometry of ligand mixtures was determined using Job plots and UV-Vis spectrometry. Monoamides were confirmed to produce only disolvate complexes with UO2+2 in solution The log10(K) values for monoamides were found to be independent of amine-side chain length, but were slightly dependent on the carbonyl-side chain length. TEDGA was found to produce multiple uranyl complexes in solution Job plot data indicated that the uranyl cation strongly prefers to bond either only with the monoamide or diamide in ternary monoamide-diamide-UO2 systems. Monoamide-diglycolamide-UO2 systems were more complicated, with Job plot data indicating the potential for multiple ternary species being present is dependent on the monoamide structure. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to trinbutyl phosphate ternary uranyl system fuel reprocessing, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 5, 2015, Gautam, Sudeep; Ishrat, Nayab; Singh, Rohit; Narender, Tadigoppula; Srivastava, Arvind K. published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1. And the article contained the following:

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. Here we delineate, aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner. 2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes. Pharmacol. inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways. Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1). In summary, these findings suggest that aegeline stimulates the glucose transport through Akt and Rac1 dependent distinct parallel pathways and have cytoskeletal roles via stimulation of the PI3-kinase-Rac1-PAK1-cofilin pathway in the skeletal muscle cells. Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline antidiabetic aegle leaf extract akt rac1 signaling diabetes, aegeline, aegle marmelos, c2c12 myotubes, cofilin, glucose uptake, insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2013, Karmase, Aniket; Birari, Rahul; Bhutani, Kamlesh K. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Evaluation of anti-obesity effect of Aegle marmelos leaves. And the article contained the following:

The study was carried out to investigate the anti-obesity effects of Aegle marmelos leaves extracts and its phytochem. constituents in vitro and in vivo. The dichloromethane (DCM), Et acetate (EtOAc) and n-butanol extracts of A. marmelos leaves were studied for their lipolytic effect. Lipolysis was measured by determining the amount of glycerol released at 12 h and 24 h at 50 μg/mL and 100 μg/mL concentrations Phytochem. investigation of the most active DCM extract yielded 14 compounds The isolated compounds were evaluated for their lipolytic effects at 50 μM and 100 μM. The most active compounds, umbelliferone and esculetin were further screened for their antiobesity effects in vivo in the high fat diet (HFD) induced obese rat model. Umbelliferone and esculetin reduced body weight, total triglyceride (TG), total cholesterol (TC) and glucose level in their resp. HFD groups. A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle umbelliferone esculetin antiobesity agents lipolysis obesity, adipocytes, aegle marmelos, anti-obesity, high fat diet, lipolysis, rat model, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gopalan, D. H.; Vani, M.; Manikandan, S.; Vijayakumar, V. published an article in 2021, the title of the article was An immunohistochemical and biochemical evidences of pancreatic β-cell regeneration in type 2 diabetic rats after treated with Aegle marmelos leaf extract and Aegeline.Category: amides-buliding-blocks And the article contains the following content:

The study aims to investigate the Immunohistochem. changes in pancreatic beta cells in fructose fed, streptozocin (STZ) induced Type 2 Diabetes (T2DM) rats treated with various doses of leaf extract of Aegle marmelos (AAM) and Aegeline (AG). 42 adult male wistar albino rats were separated into 7 groups, including Vehicle Control (VC); T2DM; T2DM + AAM 250 mg/kg; T2DM + AAM 500 mg/kg; T2DM + AG 20mg/kg; T2DM + AG 50 mg/kg and T2DM + AG 100 mg/kg. Exptl. T2DM was created by a single dose of 40 mg/kg STZ injection intra-peritoneally along with 10% of fructose solution given orally for 30 days. Calculated dosages of AAM and AG were given with oral gavage for 30 days. Pancreas was harvested and processed. Slides were stained using hematoxylin and eosin (H & E) stains. Insulin expressing beta-cells was analyzed using immunohistochem. Fructose fed, STZ induced rats showed degenerative expressions in beta-cells. In STZ treated rats, AG reduced the blood glucose concentration and serum insulin levels at the maximum functional dose compared to AAM. The immunohistochem. information suggests that the AG at 100 mg/kg dose has the capability of making the dormant cells to reproduce to restore the lost cells of islets of Langerhans. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to diabetics aegle marmelos leaf extract aegeline pancreatic beta cell, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2007, Narender, T.; Shweta, S.; Tiwari, P.; Reddy, K. Papi; Khaliq, T.; Prathipati, P.; Puri, A.; Srivastava, A. K.; Chander, R.; Agarwal, S. C.; Raj, K. published an article.Category: amides-buliding-blocks The title of the article was Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. And the article contained the following:

The plant Aegle marmelos belongs to the family of Rutaceae. From the leaves of A. marmelos an alkaloidal-amide, Aegeline, was isolated and found to have antihyperglycemic activity as evidenced by lowering the blood glucose levels by 12.9% and 16.9% at 5 and 24 h, resp., in sucrose challenged streptozotocin induced diabetic rats (STZ-S) model at the dose of 100 mg/kg body weight Aegeline 2 has also significantly decreased the plasma triglyceride (Tg) levels by 55% (P < 0.001), total cholesterol (TC) by 24% (P < 0.05), and free fatty acids (FFA) by 24%, accompanied with increase in HDL-C by 28% and HDL-C/TC ratio by 66% in dyslipidemic hamster model at the dose of 50 mg/kg body weight The reasonable mapping of compound 2 to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity (283 nM) suggest that the compound 2 might be a β3-AR agonist. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to aegle alkaloid aegeline antidyslipidemic antihyperglycemic, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Waleed, Hadeer Q.; Csecsi, Marcell; Konyhas, Vivien; Boros, Zsanett R.; Viskolcz, Bela; Fejes, Zsolt; Fiser, Bela published an article in 2022, the title of the article was Aliphatic tertiary amine catalyzed urethane formation – a combined experimental and theoretical study.Application In Synthesis of 1,3-Diphenylurea And the article contains the following content:

A kinetic and mechanistic investigation of the alcoholysis of Ph isocyanate (PhNCO) using stoichiometric butan-1-ol (BuOH) in acetonitrile in the presence of different tertiary amine catalysts was performed. The reaction mechanisms in the absence and presence of exptl. applied catalysts were described by using the G3MP2BHandHLYP composite method. The apparent activation energies obtained from the calculations were in good agreement with the exptl. data (ΔΔE = <2 kJ mol-1). Both exptl. and theor. results proved the important effect of tertiary amine catalysts on urethane formation. These results can aid in polyurethane catalyst design and development. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to phenylisocyanate butanol tertiary amine alcoholysis kinetics mechanism, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 19, 2022, Ma, Chao; Chen, Yan; Ren, Wen dong; Liu, Xing yu; Gu, Wen; Zhou, Hui li published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was Performance Evaluation of Composite Antisalt Agents and the Antisalt Dynamics Simulation Mechanism. And the article contained the following:

The conventional ferrocyanide complex ([Fe(CN)6]4-) has been widely used as a scale inhibitor under mild conditions, but its oxidation at high temperature compromises the subsequent wastewater treatment processes. To conquer the inadequacies of [Fe(CN)6]4-, aminotriacetamide (NTA) was synthesized using chloroacetic acid as an initial material and its mol. structure was characterized using FT-IR spectroscopy, H-NMR, and TGA. NTA was exploited in combination with polyaspartic acid (PASP) and sodium dodecyl benzene sulfonate (SDBS) to prepare a high-performance antisalt composite, and the scaling inhibitor performance was evaluated. The results revealed that as the concentration of the antisalt composite increased from 0.5 to 1.2 weight %, the solubility and inhibition rate increased by 95.6 and 12.33%, resp., at 100°C. The results from mol. simulation evidenced that the order of binding energy between a unit mass of the salt inhibitor and sodium chloride crystal increased in the following order; SDBS > NTA > PASP. The deformation strength between the salt inhibitor and sodium chloride crystal increased as follows: NTA > PASP > SDBS. In addition, the antisalt composite mainly hampered salt precipitation through strong adsorptions arising from both the nitrogen atom of NTA and oxygen atom of SDBS with the sodium atom of sodium chloride crystals, and as a result, it not only altered the crystalline form of sodium chloride but also reduced the adsorption of sodium atoms and eventually improved the salt solubility The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to composite antisalt dynamic simulation, Water: Composition and Properties Of Boiler Water and Other Industrial Waters and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 26, 2017, Peters, Edward Norman; Na, Ying; Ma, Shuailei; Yang, Jian published a patent.Electric Literature of 5455-98-1 The title of the patent was Method for production of cured epoxy material and composite core for aluminum conductor composite core reinforced cable. And the patent contained the following:

A method of forming a cured epoxy material comprises reacting a phenylene ether oligomer with an anhydride hardener to form a first product, adding an epoxy resin to the first product to form a second product, and curing the second product. The method provides an improved balance of heat resistance and toughness relative to corresponding methods in which the phenylene ether oligomer is pre-reacted with the epoxy resin prior to addition of hardener, and in which all components are mixed simultaneously. The cured epoxy material can be used in the composite core of an aluminum conductor composite core reinforced cable. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to oligophenylene ether anhydride hardener prereaction epoxy resin curing, aluminum conductor epoxy resin composite core reinforced cable, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics