Category: amides-buliding-blocks

On December 7, 2018, Baghdady, Yehia Z.; Schug, Kevin A. published an article.Electric Literature of 27115-50-0 The title of the article was A novel diagnostic in situ derivatization kit for the simultaneous determination of 14 biomarkers of exposure to benzene, toluene, ethyl benzene and xylenes in human urine by isotope dilution liquid chromatography tandem mass spectrometry and kit optimization using response surface methodology. And the article contained the following:

Metabolite profiling can be used as a diagnostic measure for both short and long term co-exposure by individuals to benzene, toluene, ethylbenzene and xylenes (BTEX). A novel one pot derivatization in situ kit (OPDISK) was developed and optimized using a multivariate approach based on central composite design. The OPDISK was designed to simultaneously derivatize, in a urine sample matrix, a series of fourteen carboxylic acid and phenol-bearing urinary metabolites of BTEX to enhance their chromatog. anal. and sensitivity for detection by liquid chromatog. – electrospray ionization – tandem mass spectrometry (LC-ESI-MS/MS). Using the reagent kit, the less responsive functional units on the mols. were converted to permanently pos.-charged functional units. The kit was composed of three components, 2-fluoro-1-methylpyridinium p-toluenesulfonate (FMP), 3-carbinol-1-methylpyridinium iodide (CMP) and triethylamine (TEA) as a basic catalyst and, only after diluting a urine sample 20-fold with acetonitrile, was applied under mild conditions of room temperature and short reaction time of 20 min. The derivatized biomarkers were then directly analyzed using isotope dilution LC-ESI-MS/MS. The method was sensitive (limit of detection on column ranged from 1.4 pg to 3.1 ng), accurate (mean accuracy from 85% to 114%), and precise (mean coefficient of variation from 1% to 14%). The method results indicated a good linearity (R2 ≥0.990) for all metabolites. ClinChek urine control samples were used successfully to demonstrate the accuracy of the method. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to benzene toluene ethylbenzene xylene exposure biomarker determination urine, btex exposure biomarker determination human urine lc ms opdisk, btex, biomarkers, central composite design, in situ derivatization, metabolites, occupational exposure and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2021, Pinilla Pena, Diana C.; Ruiz Pereyra, Elba N.; Firpo, Guadalupe; Ceballos, Noelia M.; Fueloep, Ferenc; Szakonyi, Zsolt; Iriarte, Ana G.; Pelaez, Walter J. published an article.Electric Literature of 102-07-8 The title of the article was Flash Vacuum Pyrolysis (FVP) of cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imine and Thiazin-2-imine Derivatives. And the article contained the following:

Cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imines and cis-N-phenyl-hexahydro-2H-benzo[d][1,3]thiazin-2-imines I (R = H, Me, PhC2; X = O, S) were prepared and subjected to flash vacuum pyrolysis (FVP). N-H- and N-Me tetrahydrobenzoxazines reacted at lower temperatures than N-H and N-Me tetrahydrobenzothiazines, showing lower thermal stabilities, while the N-benzyl tetrahydrobenzothiazine was less stable than the N-benzyl tetrahydrobenzoxazine. Oxazines and thiazines yielded different products through homolytic fragmentations of the heterocycle moiety, the stability of which increased with the N- substitution. Based on the anal. of the reaction temperatures and the unraveling of the obtained products, it is proposed that any heterocyclic ring-opening reactions (initiated by X3-C4, C8a-N1, or C2-X3 bond rupture) require less energy than the retro-Diels-Alder process (RDA) that yields butadiene. This concerted reaction path is only achieved at temperatures higher than 470°C. Kinetic measurements reveal neg. entropies of activation, which suggest a partially concerted way of reaction or slightly asynchronous fragmentation processes, with higher energy of activation (Ea) values for the N-substituted derivatives compared to the unsubstituted ones. Exptl. results agree with calculations at the DFT level (B3LYP/6-311+G(d,p)) and M06-2X (6-311+G(d,p)) from Gaussian09 software. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to hydrobenzoxazinimine hydrobenzothiazinimine preparation flash vacuum photolysis fragmentation, thermal fragmentation mechanism hydrobenzoxazinimine hydrobenzothiazinimine, calculated transition state structure energy thermal fragmentation hydrobenzoxazinimine hydrobenzothiazinimine, dft method difference calculation transition state structure energy fragmentation and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 2010, Fun, Hoong-Kun; Yeap, Chin Sing; Mange, Yatin; Isloor, Arun M.; Hegde, Chitrakar published an article.Application of 27115-50-0 The title of the article was N-[(4-Amino-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-methylbenzamide. And the article contained the following:

In N-[(4-amino-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-methylbenzamide, C11H13N5OS, the dihedral angle between the triazole ring and the benzene ring is 84.21(7)°. The amino group adopts a pyramidal configuration. An intramol. N-H···O H bond stabilizes the mol. structure and generates an S(8) ring. In the crystal, mols. are linked by intermol. N-H···O, N-H···S, N-H···N and C-H···S H bonds into layers lying parallel to the bc plane. The crystal structure is further stabilized by aromatic π-π stacking interactions [centroid-centroid distance = 3.3330(7) Å]. Crystallog. data are given. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application of 27115-50-0

The Article related to crystal structure aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, mol structure aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, hydrogen bond aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, pi stacking aminosulfanylidenedihydrotriazolylmethylmethylbenzamide, triazolylmethylmethylbenzamide aminosulfanylidenedihydro crystal mol structure and other aspects.Application of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 15, 2020, Teng, Yu; Li, Xinyu; Ren, Shengnan; Cheng, Yu; Xi, Kun; Shen, Hongtao; Ma, Wenzhuo; Luo, Guoshun; Xiang, Hua published an article.Quality Control of N-(3-Aminophenyl)acrylamide The title of the article was Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity. And the article contained the following:

Herein, a series of quinazoline derivatives I [R1 = Br, 3-pyridyl, (6-fluoro-3-pyridyl), (6-chloro-3-pyridyl), 3-quinolyl; R2 = vinyl, Et, HC=CH2CH3, C≡CCH3; R3 = H, Me] bearing acrylamide fragment were prepared using skeleton-deconstruction strategy. The preliminary bioactivity evaluation resulted in the discovery of lead compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me]. Compound I [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] exhibited excellent enzyme activity against PI3Kδ (IC50 = 27.5 nM) compared with BEZ235 as well as the significant anti-proliferation activities. With the high selectivity over other PI3K isoforms and potent effects on PI3K/Akt pathway, compoundI [R1 = 3-quinolyl; R2 = vinyl; R3 = Me] could be identified as a promising PI3Kδ inhibitor worthy of further profiling. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide

The Article related to quinazoline preparation pi3k delta inhibitor docking human, bromoquinazolinyl amino phenyl boric acid suzuki coupling catalyst palladium, boric acid bromoquinazolinyl oxy phenyl suzuki coupling catalyst palladium, quinolineboronic acid bromoquinazolinyl amino phenyl suzuki coupling catalyst palladium, b-cell malignancies, pi3kδ, quinazoline derivatives and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2021, Zhang, Xin; Geng, Peiyu; Liu, Guixia; Huang, Zheng published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Ru-Catalyzed Site-Selective Aliphatic C-H Bond Silylation of Amides and Carbamides. And the article contained the following:

Hydrido Ru complexes (POCNP)RuH(NBD) (NBD = norbornadiene) supported by N/O-bridged pincer ligands were synthesized and characterized. The Ru complex containing a pincer ligand with an indolol scaffold exhibits high catalytic activity for the intermol. aliphatic C-H bond silylation of amides and carbamides. The reaction proceeds selectively at the C-H bonds adjacent to the N atom to efficiently afford α-silyl amides and carbamides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to hydridoruthenium pincer complex containing diphosphinated indolol ligand preparation catalyst, crystal structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, mol structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, diphosphinated indolol ligand preparation cyclometalation ruthenium complex and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Name: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 26, 1998, Potrzebowski, Marek J.; Michalska, Maria; Koziol, Anna E.; Kazmierski, Slawomir; Lis, Tadeusz; Pluskowski, January; Ciesielski, Wlodzimierz published an article.Related Products of 97-09-6 The title of the article was Structural Implications of C-H···S Contacts in Organophosphorus Compounds. Studies of 1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose by X-ray and Solid-State NMR Methods. And the article contained the following:

1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose (1, C18H25O8PS3), crystallized from polar and/or nonpolar solvents, forms different modifications in the solid phase. Crystal structures of 1 (obtained from a methanol solution) and its 2-propanol solvate (1a) were established by X-ray structure anal. at low temperature One-component crystal 1 is orthorhombic, space group P212121, with a = 7.483(4) Å, b = 11.156 (6) Å, c = 27.11(2) Å, V = 2263 (2) Å3, Z = 4, and Dc = 1.457 g cm-3. The crystal of 1a is an inclusion structure containing mols. of 1 and 2-propanol in the ratio 1/1; crystals are triclinic, space group P1, with a = 9.637(6) Å, b = 9.709(6) Å, c = 8.865(8) Å, α = 110.27(5)°, β = 106.33(5)°, γ = 108.70(6)°, V = 661.3(8) Å3, Z = 1, and Dc = 1.398 g cm-3. Intermol. hydrogen bonds (O-H···O, C-H···O in 1; O-H···O, O-H···S in 1a) are present along with the C-H···S:P intermol. interactions. The solid-state structures were studied by the NMR spectroscopy. The presence of toluene-d8 in the crystal lattice of inclusion complex was confirmed by 2H NMR spectroscopy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to toluene inclusion anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, propanol solvate anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, intermol hydrogen bond anhydrotosylthioxadioxaphosphorinanyl glucopyranose nmr, mol crystal structure anhydrotosylthioxadioxaphosphorinanyl glucopyranose and other aspects.Related Products of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 24, 2016, Shia, Kak-Shan; Jan, Jiing-Jyh; Tsou, Lun Kelvin; Chen, Chiung-Tong; Chao, Yu-Sheng published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of quinazoline heterocyclic compounds and use thereof to mobilize hematopoietic stem cells and endothelial progenitor cells. And the patent contained the following:

Heterocyclic compounds I [wherein: M = (CH2)m; each of R1 and R2, independently, is H, halogen, NO2, CN, NH2, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; or, R1 and R2, together with the two carbon atoms to which they are bonded, are C5-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl, each of alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [Each of R3 and R4, independently, is NRbRc, Z1 or Z2; in which: each of Rb and Rc, independently, is H or C1-6-alkyl;R5 is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, arylalkyl, heteroaryl alkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, aryl, and heteroaryl being optionally substituted;]. [R6 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl;L1 is heteroaryl, C1-10-heterocycloalkyl, NH, or NRd; in which Rd is C(:O)(CH2)2CHNH2CO2Re; Re being H, C1-6-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl;R7 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, alkoxyl, cycloalkyl,heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [M is 1 – 6; n is 1 – 6; each of R8 and R9, independently, is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted; L2 is C1-6-alkyl; or L2, together with R8 8or R9 and the nitrogen atom to which they are bonded, is C4-10-heterocycloalkyl or heteroaryl; and,]. [R10 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, ester, amide thioamide, or acyl; each of alkyl, alkoxyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl alkyl, and heteroaryl alkyl being optionally substituted] are shown herein. Thus, quinazoline II was prepared from 2,4-dichloroquinazoline via amination with tert-Bu 4-aminopiperidine-1-carboxylate; amination with aminotriazle III; and debutoxycarbonylation. The synthesis of II is also desribed. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to heterocyclic compound preparation pharmaceutical composition mobilizer hematopoietic stem cells, tissue injury treatment quinazoline pyrimidine compound, cancer treatment quinazoline pyrimidine compound, inflammatory disease treatment quinazoline pyrimidine compound, autoimmune disease treatment quinazoline pyrimidine compound and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2022, Franchino, Allegra; Marti, Alex; Echavarren, Antonio M. published an article.Electric Literature of 102-07-8 The title of the article was H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis. And the article contained the following:

A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asym. induction. The successful implementation of this paradigm is demonstrated in 5-exo-dig and 6-endo-dig cyclizations of 1,6-enynes, combining an achiral phosphinourea Au(I) chloride complex with a BINOL-derived phosphoramidate Ag(I) salt and thus allowing the 1st general use of chiral anions in Au(I)-catalyzed reactions of challenging alkyne substrates. Experiments with modified complexes and anions, 1H NMR titrations, kinetic data, and studies of solvent and nonlinear effects substantiate the key H-bonding interaction at the heart of the catalytic system. This conceptually novel approach, which lies at the intersection of metal catalysis, H-bond organocatalysis, and asym. counterion-directed catalysis, provides a blueprint for the development of supramolecularly assembled chiral ligands for metal complexes. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to silver binaphtholphosphinate preparation catalyst enyne cyclization crystal structure, crystal structure silver binaphtholphosphinate gold phosphinothiourea complex, mol structure silver binaphtholphosphinate gold phosphinothiourea complex, gold phosphinothiourea complex preparation catalyst enyne cyclization crystal structure and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2020, Tong, Dan; Chen, Jiangyao; Qin, Dandan; Ji, Yuemeng; Li, Guiying; An, Taicheng published an article.Related Products of 685-91-6 The title of the article was Mechanism of atmospheric organic amines reacted with ozone and implications for the formation of secondary organic aerosols. And the article contained the following:

Organic amines are a most important N-containing compounds in the atm.; their reactions with tropospheric O3 significantly contribute to secondary organic aerosols (SOA) formation. But the chem. pathways of their reaction with atm. O3 are poorly understood. This work examined the atm. ozonolysis mechanism for two typical organic amines (diethylamine, triethylamine) using exptl. and theor. methods. Intermediate gas chromatog./mass spectrometry and proton transfer reaction /time-of-flight mass spectrometry anal. results confirmed formation of 8 and 11 N- and O-containing products during diethylamine and triethylamine ozonolysis, resp. N-ethylethanimine (average 56.5%) or acetaldehyde (average 64.9%) was formed as the dominant product from ozonolysis of each organic amine. Ozonolysis pathway results indicated conversion to N-ethylethanimine was the dominant pathway for diethylamine ozonolysis. Simultaneously, triethylamine preferred an initial transformation to diethylamine with discharge of acetaldehyde then conversion to N-ethylethanimine. Higher SOA mass concentrations were obtained from triethylamine vs. diethylamine ozonolysis, probably because the former released a larger amount of intermediate products, particularly acetaldehyde. Results provided a deep insight into atm. processing of organic amines via ozonolysis and implications of this mechanism for SOA formation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to atm ozonolysis organic amine secondary organic aerosol formation, diethylamine triethylamine atm ozonolysis secondary organic aerosol formation, reaction pathway transformation mechanism organic amine atm ozonolysis, ozonolysis intermediate byproduct organic amine reaction, atmospheric organic amine, carbonyl intermediate and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics