Category: amides-buliding-blocks

On October 15, 2021, Wang, Zhiguo; Li, Shijiang; Li, Ronghao; Luo, Chunyan published a patent.Formula: C6H11NO The title of the patent was Preparation of indoline-5-methylamine dihydrochloride from indole. And the patent contained the following:

The present invention relates to the preparation of indoline-5-methylamine dihydrochloride from indole. In particular, the preparation method comprises of following steps: (1) using indole as a raw material, and reacting with an acid to obtain a formyl-protected indoline; (2) carrying out Friedel-Crafts reaction of the formyl protected indoline with an amination reagent to obtain 5-[(1,3-dioxoisoindolin-2-yl)methyl]indole-1-carbaldehyde; (3) the obtained intermediate compound is treated with hydrazine hydrate to obtain 5-(aminomethyl)indole-1-aminoaldehyde; and (4) carrying out the deprotection reaction of 5-(aminomethyl)indole-1-aminoaldehyde to obtain the target product indoline-5-methylamine dihydrochloride. The inventive method has a short process route, low cost, easy availability of raw materials and auxiliary materials, high reactivity, simple operation, easy control, and has high yield of the target product, which is convenient for industrial scale-up. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Formula: C6H11NO

The Article related to indole formic acid formylation reduction, formylindoline preparation hydroxymethyl phthalimide compound friedel crafts reaction, dioxyisoindolinyl methylindole formaldehyde preparation amination, aminomethyl dihydro indole carboxaldehyde preparation deprotection, indoline methylamine dihydrochloride preparation and other aspects.Formula: C6H11NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 27, 2017, Mancini, Alessandra; Chelini, Alessia; Di Capua, Angela; Castelli, Loretta; Brogi, Simone; Paolino, Marco; Giuliani, Germano; Cappelli, Andrea; Frosini, Maria; Ricci, Lorenzo; Leonelli, Erminia; Giorgi, Gianluca; Giordani, Antonio; Magistretti, Jacopo; Anzini, Maurizio published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents. And the article contained the following:

The synthesis of differently functionalized 4H-3,1-benzothiazine I and 2H-1,4-benzothiazine II [X = CH2, S; Y = CH2, S; R = H, OCF3; R1 = R2 = H, Me, Et, n-Pr] series as superior homologs of rizuline were reported. Biol. evaluation demonstrated that amidine 4H-3,1-benzothiazine derivatives I [R1 = R2 = H, Et, n-Pr] reduces glutamate and LDH release in the oxygen/glucose deprivation and reperfusion model (OGD/R) applied to brain slices with a higher potency than rizuline. Moreover the mentioned compounds significantly reduced glutamate- and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in neuroblastoma cells. In addition, the same compounds limit ROS formation in both neuronal preparations Finally, compound I [R1 = R2 = Et] proved effective in inhibiting neuronal voltage-dependent Na+ and Ca2+-channels, showed a profile comparable with that of rizuline. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzothiazinyl acetamidine preparation neuroprotective agent antioxidant sar, propylthiourea benzothiazinyl preparation neuroprotective agent antioxidant sar, benzothiazine derivatives, neurodegenerative diseases, neuronal voltage-dependent na(+) and ca(2+) currents, neuroprotective agents, sh-sy5y cells and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Xiang; Nguyen, Edward T.; Hong, Anh N.; Feng, Pingyun; Bu, Xianhui published an article in 2018, the title of the article was Chiral Isocamphoric Acid: Founding a Large Family of Homochiral Porous Materials.Safety of N,N-Diethylacetamide And the article contains the following content:

Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, D-camphoric acid is highly prolific, yet, its trans-isomer, L-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chem. has now been studied through the synthesis of a large family of homochiral metal isocamphorates. The 1st observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to chiral isocamphorate preparation homochiral porous material, transition metal isocamphorate camphorate mof preparation, crystal structure magnesium cobalt copper isocamphorate camphorate mof, camphoric acid, chiral ligands, homochiral porous materials, isocamphoric acid, metal-organic frameworks and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 28, 2020, Wu, Qiumin; Chen, Jinzhu; Liu, Zhen; Xu, Yisheng published an article.Name: 1,3-Diphenylurea The title of the article was CO Activation Using Nitrogen-Doped Carbon Nanotubes for Reductive Carbonylation of Nitroaromatics to Benzimidazolinone and Phenyl Urea. And the article contained the following:

Carbonylation of nitroaroms. with CO is extensively investigated with efficient but precious group 8-10 metal-based catalysts for the productions of both industrially and academically important chems. such as isocyanates, formamides, carbamates, ureas and several types of heterocyclic compounds Herein, we report that rationally designed nitrogen-doped carbon nanotubes (N-CNTs) exhibit catalytic activity toward CO activation for carbonylation of nitroaroms. to benzimidazolinones and ureas. Under the optimal conditions, N-CNT-promoted intramol. carbonylation of 2-nitroaniline (1a) with CO leads to formation of 1,3-dihydro-2H-benzo[d]imidazol-2-one in 90% yield. Moreover, an intermol. carbonylation of nitrobenzene and aniline with CO in the presence of the N-CNT gives 70% yield of N,N’-diphenylurea. The N-CNT is also applicable to various benzimidazolinones and Ph ureas; moreover, it can be readily reused at least 9 times for the carbonylation. The theor. investigation based on d. functional theory calculations indicates that the graphitic N of the N-CNT plays a crucial step in the 1a reduction with CO. The correlation between the structural defect and catalytic performance of the N-CNT reveals an enhanced catalytic activity of the N-CNT with its increased structural defects. This research thus represents a major breakthrough in CO activation for nitroarom. carbonylation with environmental-friendly, low-cost, and carbon-based catalysts as a potential alternative to expensive and scarce noble-metal-based catalysts. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to nitrogen doped carbon nanotube catalyst reductive carbonylation nitroarom aniline, carbon monoxide activation nitrogen doped carbon nanotube, benzimidazolinone ph urea preparation green chem mol modeling, carbon catalysis, carbon monoxide, carbonylation, defect, nitrogen-doped carbon nanotubes and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2016, Toda, Yasunori; Komiyama, Yutaka; Kikuchi, Ayaka; Suga, Hiroyuki published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Tetraarylphosphonium Salt-Catalyzed Carbon Dioxide Fixation at Atmospheric Pressure for the Synthesis of Cyclic Carbonates. And the article contained the following:

Phosphonium salts exhibit great utility in organic synthesis. However, tetraarylphosphonium salts (TAPS) have found limited use as catalysts. We demonstrate the TAPS-catalyzed carbon dioxide fixation at atm. pressure for the coupling reaction with epoxides. Five-membered cyclic carbonates were obtained, including enantio-enriched carbonates. Mechanistic studies revealed the origin of the behavior of TAPS to be the in situ formation of an active species by TAPS addition to epoxides via halohydrin intermediates. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to cyclic carbonate preparation carbon dioxide fixation epoxide atm pressure, tetraarylphosphonium salt preparation catalyst carbon fixation, crystal mol structure hydroxy methylphenyl triphenylphosphonium bromide, carbon dioxide fixation tetraarylphosphonium salt catalyzed epoxide atm pressure and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2015, Wan, Yichao; Wu, Shaolei; Xiao, Guizhi; Liu, Tingting; Hou, Xuben; Chen, Chen; Guan, Peng; Yang, Xinying; Fang, Hao published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. And the article contained the following:

The B-cell lymphoma-2 (Bcl-2) protein is a promising target for cancer therapy. In the present study, a series of 2-thioxo-4-thiazolidinone derivatives were designed and synthesized as Bcl-2 inhibitors. Most of them possessed decent inhibitory activity for anti-apoptotic Bcl-2 proteins. Among them, compound I has similar growth inhibition towards K562 compared to (R)-Gossypol. In addition, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 74 nM. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to thioxothiazolidinone derivative preparation preliminary bioactivity bcl2 inhibitor, oxothiazolidinethione derivative preparation preliminary bioactivity bcl2 inhibitor, cancer therapy growth inhibition thioxothiazolidinone derivative, 2-thioxo-4-thiazolidinone, anti-tumor, bcl-2, inhibitors and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2021, Kumar, Vishal; Dhawan, Sanjeev; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application of 685-91-6 The title of the article was An Environmentally Benign, Catalyst-Free N-C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides. And the article contained the following:

An operationally simple, cheap and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol was environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy was implied in the chemoselective synthesis of a pharmaceutical mol., paracetamol, on a gram-scale with excellent yield. Anticipated that this was universally applicable strategy will be of great interest in drug discovery, biochem., and organic synthesis. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to formamide amine hydrochloride n formylation transamidation green chem, arylformamide preparation, acetamide amine hydrochloride n acylation transamidation green chem, arylacetamide preparation, benzamide amine hydrochloride n benzoylation transamidation green chem, arylbenzamide preparation and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Knippen, Katharina; Bredenkoetter, Bjoern; Kanschat, Lisa; Kraft, Maryana; Vermeyen, Tom; Herrebout, Wouter; Sugimoto, Kunihisa; Bultinck, Patrick; Volkmer, Dirk published an article in 2020, the title of the article was CFA-18: a homochiral metal-organic framework (MOF) constructed from rigid enantiopure bistriazolate linker molecules.COA of Formula: C2H4ClNO And the article contains the following content:

In this work, authors introduce the first enantiopure bistriazolate-based metal-organic framework, CFA-18 (Coordination Framework Augsburg-18), built from the R-enantiomer of 7,7,7′,7′-tetramethyl-6,6′,7,7′-tetrahydro-3H,3’H-5,5′-spirobi[indeno[5,6-d]-[1,2,3]triazole] (H2-spirta). The enantiopurity and absolute configuration of the new linker were confirmed by several chiroselective methods. Reacting H2-spirta in hot N,N-dimethylformamide (DMF) with manganese(II) chloride gave CFA-18 as colorless crystals. The crystal structure with the composition [Mn2Cl2(spirta)(DMF)2] was solved using synchrotron single-crystal x-ray diffraction. CFA-18 shows a framework topol. that is closely related to previously reported metal-azolate framework (MAF) structures in which the octahedrally coordinated manganese(II) ions are triazolate moieties, and the chloride anions form crosslinked one-dimensional helical chains, giving rise to hexagonal channels. In contrast to MAFs crystallizing in the centrosym. space group R3, the handedness of the helixes found in CFA-18 is strictly uniform, leading to a homochiral framework that crystallizes in the trigonal crystal system within the chiral space group P3121 (number 152). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to tetramethyltetrahydrospiro biindenediol homochiral metal organic framework preparation crystal structure, mof rigid enantiopure bistriazolate linker mol preparation crystal structure, manganese tetramethyltetrahydrospiro biindenediol homochiral metal organic framework preparation structure and other aspects.COA of Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parzuchowski, Pawel G.; Swiderska, Aleksandra; Roguszewska, Marlena; Rolinska, Karolina; Wolosz, Dominik; Maminski, Mariusz published an article in 2020, the title of the article was Hyperbranched poly(ether-siloxane)s containing ammonium groups: Synthesis, characterization and catalytic activity.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

In this article we report an easy synthetic route towards hyperbranched polyglycerols (Amm-HBPGs) containing trimethylammonium groups and siloxane or hydroxyl end-groups. Siloxane derivatives of Amm-HBPGs were synthesized in an efficient five-step procedure including an anionic ring opening copolymerization of the phthalimide-epoxy monomer with glycidol, followed by reactions with allyl bromide, hydrosilylation with hydrogenheptamethyltrisiloxane, hydrazinolysis of phthalimide groups and quaternization of resulting amine groups with Me iodide. Hydroxyl derivatives were obtained by quaternization of previously reported aminated HBPG’s with Me iodide. Polymeric products were characterized using various NMR techniques, FTIR, and elemental anal. Both Amm-HBPGs were shown to be effective in catalysis of addition of CO2 to oxirane. The hydrophilic catalysts showed higher efficiency but synthesis of ethylene carbonate was accompanied by formation of small amounts of ethylene glycol. The siloxane-containing catalyst was easily separable from reaction mixture showing high potential in the process of converting carbon dioxide into valuable chem. raw materials. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to trimethylammonium polyether siloxane hyperbranched polymer anionic ring opening copolymerization, carbon dioxide oxirane ethylene carbonate cycloaddition catalyst, carbon dioxide, catalysis, cycloaddition, ethylene carbonate, hyperbranched polymer, oxirane, polyglycidol, polysiloxane and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2019, Hu, Cong; Yang, Zhen; Yan, Fuhua; Sun, Biancheng published an article.Formula: C10H11NO3 The title of the article was Extraction of the toluene exposure biomarkers hippuric acid and methylhippuric acid using a magnetic molecularly imprinted polymer, and their quantitation by LC-MS/MS. And the article contained the following:

A magnetic polymer was molecularly imprinted with hippuric acid (HA) to obtain a nanomaterial with an architecture of type Fe3O4@SiO2@MIP. It was used as a sorbent for magnetic solid phase extraction of HA and methylhippuric acids (2-MHA, 3-MHA, 4-MHA) from urine samples. The resp. imprinting factor are 4.6, 2.7, 2.0 and 1.8, resp., and the selectivity coefficients are 1.7, 2.3 and 2.6. The effects of adsorbent amount, extraction time, pH value, ionic strength, desorption solvent and desorption time on the extraction of HA and MHA were investigated. Following elution with 1 mM NaOH solution, the 4 HAs were quantified by ultra-performance liquid chromatog. with mass spectrometric detection. Under the optimal exptl. conditions, the limits of detection (at S/N = 3) range between 89 ng·L-1 (for HA) and 170 ng·L-1 (for 4-MHA), the limits of quantification (at S/N = 10) range between 300 ng·L-1 (for HA) and 570 ng·L-1 (for 4-MHA), the linear range extends from 500 ng·L-1 to 10 mg·L-1, the relative standard deviations of intra-day range between 6.4 and 9.6% (for n = 6 at 10μg·L-1) and inter-day range between 9.2 and 11.5% (for n = 6 at 10μg·L-1). The method was successfully applied to the anal. of HA and MHA in (spiked) urine, and good recoveries were obtained. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to lc ms toluene biomarker hippuric methylhippuric acid polymer china, fourier transform infrared spectrometry, magnetic solid phase extraction, transmission electron microscopy, ultrasonic liquid desorption, urine analysis, vortex-assisted extraction, x-ray photoelectron spectroscopy and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics